Chymostatin -

CAS 9076-44-2 MFCD00071059

化学结构图

9076-44-2
SMILES: CC(C)CC(NC(=O)C(NC(=O)NC(Cc1ccccc1)C(=O)O)C1CCN=C(N)N1)C(=O)NC(C=O)Cc1ccccc1

化学属性

Mol. Weight
Mol. FormulaCₓHyN₇O₆
Density1.34
Melting Point210-213ºC
Boiling Point
Flash Point-

别名和识别编码

Synonym (2S)-2-[[(1S)-1-(2-Amino-3,4,5,6-tetrahydropyrimidin-4-yl)-2-[[(2S)-4-methyl-1-oxo-1-[[(2S)-1-oxo-3-phenylpropan-2-yl]amino]pentan-2-yl]amino]-2-oxoethyl]carbamoylamino]-3-phenylpropanoic acid Chymostatin {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {A {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
MDL Number-
CAS Number9076-44-2
Chemical NameChymostatin
Chemical Name Translation-
InChIKeyQJIJPLFVFWXMGK-KSPFWWQASA-N
PubChem Substance ID443119
InChIInChI=1S/C31H41N7O6/c1-19(2)15-24(27(40)34-22(18-39)16-20-9-5-3-6-10-20)35-28(41)26(23-13-14-33-30(32)36-23)38-31(44)37-25(29(42)43)17-21-11-7-4-8-12-21/h3-12,18-19,22-26H,13-17H2,1-2H3,(H,34,40)(H,35,41)(H,42,43)(H3,32,33,36)(H2,37,38,44)/t22-,23?,24-,25-,26-/m0/s1
Canonical SMILES-
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分类

  • {SNA} A to C, Apoptosis Enzymes, Application Index, Broad Spectrum Inhibitors of Proteolytic Enzyme Classes, Cathepsin B, Cathepsin B Inhibitors, Cathepsin D, Cathepsin D Inhibitors, Cathepsin G, Cathepsin G Inhibitors, Cathepsin/Granzyme Inhibitors & Substrates, Cell Signaling Enzymes, Chymotrypsin, α-, Chymotrypsin, alpha-, Core Bioreagents, Cysteine Protease Inhibitors, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Individual Protease Inhibitors, Inhibitors, Life Science Reagents for Protein Expression and Purification, Lysosomal Proteases, P to Q, Papain,

相关文献及参考

  • Beynon, R.J. and Bond, J.S., ed. Proteolytic Enzymes: A Practical Approach New York, NY , (1989), 207,243
  • Levy, M.R. and Chou, S.C. Biochim. Biophys. Acta 334 , 423, (1974)
  • Umezawa, H Meth. Enzymol. 45 , 678, (1976) 摘要
  • Feinstein, G., et al. Biochim. Biophys. Acta 429 , 925, (1976) 摘要
  • Chang, K., et al., Characterization and inhibition of norovirus proteases of genogroups I and II using a fluorescence resonance energy transfer assay Virology 423 , 125-33, (2012)
  • Yoshida, T., et al., Comparative analysis of binding energy of chymostatin with human cathepsin A and its homologous proteins by molecular orbital calculation J. Chem. Inf. Model. 46 , 2093-103, (2012)
  • Wang, S., et al., Cordysobin, a novel alkaline serine protease with HIV-1 reverse transcriptase inhibitory activity from the medicinal mushroom Cordyceps sobolifera J. Biosci. Bioeng. 113(1) , 42-7, (2011)

安全信息

WGK Germany3
RTECSGC3047700
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Storage condition -20 -20°C -20℃保存。
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 1948-52;  V.21- 1968-
   Volume(issue)/page/year: 23,425,1970

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PPTCBY Proceedings of the International Symposium of the Princess Takamatsu
   Cancer Research Fund. (Japan Scientific Soc. Press, 6-2-10 Hongo, Bunkyo-ku,
   Tokyo 113, Japan)  1st-    1971-  Volume(issue)/page/year: 6,57,1976

系列性分类


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