Podophyllotoxin 鬼臼毒素

CAS 518-28-5 MFCD00075290

化学结构图

518-28-5
SMILES: COc1cc(C2c3cc4c(cc3C(O)C3COC(=O)C23)OCO4)cc(OC)c1OC

化学属性

Mol. FormulaC22H22O8
Mol. Weight414.41
Density1.422
Melting Point183-184°C
Boiling Point597.9°C at 760 mmHg

别名和识别编码

Chemical NamePodophyllotoxin
MDL NumberMFCD00075290
CAS Number518-28-5
EC Number208-250-4
Beilstein Registry Number99163
PubChem Substance ID10607
Alfabeta NameARARHYDROXYTRIMETHOXYPHENYLTETRAHYDROFURONAPHTHO RRA:D5589953455889346723[[](())--------,,,,,,,,,,,'
Synonym Podofilox {LY} Podofilox {} {LY} Podofilox {} {} {LY} Podofilox {} {} {} {LY} Podofilox {} {} {} {} {LY} Podofilox {} {} {} {} {} {LY} Podofilox {} {} {} {} {} {} {LY} Podofilox {} {} {} {} {} {} {} {LY} Podofilox {} {} {} {} {} {} {} {} {LY} Podofilox {} {} {} {} {} {} {} {} {} {LY} Podofilox {} {} {} {} {} {} {} {} {} {} {LY} Podofilox {} {} {} {} {} {} {} {} {} {} {} {LY} Podofilox {} {} {} {} {} {} {} {} {} {} {} {} {LY} Podofilox {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Podofilox {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Podofilox {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Podofilox {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Podofilox {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Podofilox {} {} {} {} {} {} {} {} {} {} {} {} {} {
Chemical Name Translation鬼臼毒素
Merck Number13,7628
LabNetwork Molecule IDLN00178261
InChIInChI=1S/C22H22O8/c1-25-16-4-10(5-17(26-2)21(16)27-3)18-11-6-14-15(30-9-29-14)7-12(11)20(23)13-8-28-22(24)19(13)18/h4-7,13,18-20,23H,8-9H2,1-3H3/t13-,18+,19-,20-/m0/s1
Canonical SMILESO=C1OC[C@]2([H])[C@@H](O)C3=C(C=C4OCOC4=C3)[C@@H](C5=CC(OC)=C(OC)C(OC)=C5)[C@]21[H]
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分类

  • {SNA} Antitumor Agents, Bioactive Small Molecule Alphabetical Index, Cytoskeleton and Extracellular Matrix, Microtubule Inhibitors, PI-PZ, 生物活性小分子, 癌症研究, 细胞信号转导和神经科学, 细胞生物学
  • {SNA} Antitumor Agents, Bioactive Small Molecules, Cell Signaling and Neuroscience, Cytoskeleton and Extracellular Matrix, Microtubule Inhibitors, P, 癌症研究, 细胞生物学
  • {SNA} Bioactive Small Molecule Alphabetical Index, Cytoskeleton and Extracellular Matrix, Microtubule Inhibitors, PI-PZ, 抗肿瘤药物, 生物活性小分子, 癌症研究, 细胞信号转导和神经科学, 细胞生物学
  • {SNA} Ant

产品应用

  • 抑制微导管（microtubule）组装；抗肿瘤。
  • 临床上用于急性单核细胞型和急性粒单核细胞型白血病，急性粒细胞白血病，慢性嗜酸粒细胞型白血病，小细胞肺癌，非何杰金氏恶性淋巴瘤、 睾丸癌等。

相关文献及参考

  • [2]. Guerrero E, Abad A, Montenegro G, et al. Analgesic and anti-inflammatory activity of podophyllotoxin derivatives. Pharm Biol. 2013 Jan 31.
  • [3]. Li M, Zhou L, Yang D, et al. Biochemical composition and antioxidant capacity of extracts from Podophyllum hexandrum rhizome. BMC Complement Altern Med. 2012 Dec 22;12:263.
  • [4]. Prasad V, Chaudhuri AR, Curcio M, et al. Podophyllotoxin and nocodazole counter the effect of IKP104 on tubulin decay. J Protein Chem. 1998 Oct;17(7):663-8.
  • [5]. Podophyllotoxin
  • Merck: 14,7546
  • Merck: 14,7546 Beilstein: 19,V,10,666
  • [1]. Wang B, Chen L, Zhen H, et al. Proteomic changes induced by podophyllotoxin in human cervical carcinoma HeLa cells. Am J Chin Med. 2013;41(1):163-75.
  • [1]. Wang B, Chen L, Zhen H, et al. Proteomic changes induced by podophyllotoxin in human cervical carcinoma HeLa cells. Am J Chin Med. 2013;41(1):163-75.
  • [2]. Guerrero E, Abad A, Montenegro G, et al. Analges

安全信息

Signal word Danger
GHS Symbol
WGK Germany3
Safety Statements
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
Risk Statements
  • R21 Harmful in contact with skin 与皮肤接触有害
  • R25 Toxic if swallowed 吞咽有毒
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P350
  • P305+P351+P338
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H310 Fatal in contact with skin 皮肤接触致命
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H301 Toxic if swallowed 吞食有毒
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
RTECSLV2500000
Warnings IRRITANT
Hazard Codes 6.1 T
Packing GroupII
Hazard Class6.1(a)
Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
UN Number 3462 UN 3462 6.1/PG 2

其他信息

  • F:1-8-10
  • 外观性质:白色结晶性粉末、 无臭无味，不溶于水、 易溶于水、易溶于氯仿、 甲醇和丙酮。熔点:178-184℃
  • MSDS 信息:(5R,5aR,8aR,9R)-5,8,8a,9-Tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-furo(3',4':6,7)naphtho[2,3-d]-1,3-dioxol-6(5aH)-one(518-28-5).msds
  • 用途一:抑制微导管（microtubule）组装；抗肿瘤。临床上用于急性单核细胞型和急性粒单核细胞型白血病，急性粒细胞白血病，慢性嗜酸粒细胞型白血病，小细胞肺癌，非何杰金氏恶性淋巴瘤、 睾丸癌等。
  • MOL 文件:518-28-5.mol
  • 鬼臼毒素价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/06/21 228410010 鬼臼毒素 Podophyllotoxin 95% 1 GR 3253元 2010/06/21 228411000 鬼臼毒素 Podophyllotoxin 95% 100 MG 537元
  • 无臭无味，不溶于水、 易溶于水、易溶于氯仿、 甲醇和丙酮。
  • 检测方法:HPLC
  • Acros Organics:鬼臼毒素 Podophyllotoxin, 95%(518-28-5)
  • 海关编码:29189090
  • 比旋光度:-110.7 ° (c=1, CHCl3)
  • Sigma Aldrich:518-28-5(sigmaaldrich)

系列性分类

  1. Life Science 生命科学
  2. Nutrition Research 营养研究
  3. Phytochemicals by Chemical Classification - Nutrition Research
  4. Plant Extracts - Phytochemicals by Chemical Classification
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. P - Bioactive Small Molecules
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Cytoskeleton and Extracellular Matrix - Cell Signaling and Neuroscience
  5. Microtobule Inhibitors - Cytoskeleton and Extracellular Matrix
  1. Chemical Synthesis 化学合成
  2. Asymmetric Synthesis 不对称合成
  3. Chiral Building Blocks 手性分子砌块
  4. Complex Molecules - Chiral Building Blocks
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Cytoskeleton and Extracellular Matrix
  5. Extracellular Matrix
  6. Angiogenesis Regulators
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Peptides and Proteins
  5. Cytoskeleton and Extracellular Matrix Proteins
  6. Extracellular Matrix
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Proteins and Derivatives
  4. Proteins for Cell Biology
  5. Cytoskeleton and Extracellular Matrix Proteins
  6. Extracellular Matrix
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Peptides and Proteins
  5. Proteins for Cell Biology
  6. Apoptosis and Cell Cycle Proteins
  7. Apoptosis Inhibitors
  1. Medical Research Areas
  2. Cytosketetal Signaling
  3. Microtubule/Tubulin  (微管/微管蛋白)

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