(Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate 1H-苯并三唑-1-基氧三吡咯烷基鏻六氟磷酸盐(PyBOP)

CAS 128625-52-5 MFCD00077411

化学结构图

128625-52-5
SMILES: F[P-](F)(F)(F)(F)F.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1

化学属性

Mol. FormulaC18H28F6N6OP2
Mol. Weight520.39
Melting Point154-156°C
TSCANo
pH:A

别名和识别编码

Chemical Name(Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate
CAS Number128625-52-5
Alfabeta NamePYBOP
MDL NumberMFCD00077411
Synonym (Benzotriazol-1-yloxy)tripyrrolidinophosphonium (hexafluorophosphate) {LY} (Benzotriazol-1-yloxy)tripyrrolidinophosphonium (hexafluorophosphate) {} {LY} (Benzotriazol-1-yloxy)tripyrrolidinophosphonium (hexafluorophosphate) {} {} {LY} (Benzotriazol-1-yloxy)tripyrrolidinophosphonium (hexafluorophosphate) {} {} {} {LY} (Benzotriazol-1-yloxy)tripyrrolidinophosphonium (hexafluorophosphate) {} {} {} {} {LY} (Benzotriazol-1-yloxy)tripyrrolidinophosphonium (hexafluorophosphate) {} {} {} {} {} {LY} (Benzotriazol-1-yloxy)tripyrrolidinophosphonium (hexafluorophosphate) {} {} {} {} {} {} {LY} (Benzotriazol-1-yloxy)tripyrrolidinophosphonium (hexafluorophosphate) {} {} {} {} {} {} {} {LY} (Benzotriazol-1-yloxy)tripyrrolidinophosphonium (hexafluorophosphate) {} {} {} {} {} {} {} {} {LY} (Benzotriazol-1-yloxy)tripyrrolidinophosphonium (hexafluorophosphate) {} {} {} {} {} {} {} {} {} {LY} (Benzotriazol-1-yloxy)tripyrrolidinophosphonium (hexafluorophosphate) {} {} {} {} {} {} {} {} {}
EC Number000-000-0
Beilstein Registry Number3584612
PubChem Substance ID87564669
Reaxys-RN3584612
Chemical Name Translation1H-苯并三唑-1-基氧三吡咯烷基鏻六氟磷酸盐(PyBOP)
Canonical SMILESF[P-](F)(F)(F)(F)F.C12=CC=CC=C1N=NN2O[P+](N3CCCC3)(N4CCCC4)N5CCCC5
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分类

  • Aromatics
  • {SA} Chemical Biology, Chemical Synthesis, Peptide Chemistry, Peptide Coupling, Phosphonium/Uronium/Formamidinium
  • Miscellaneous Reagents
  • {SNA} Chemical Biology, Chemical Synthesis, Coupling, Peptide Chemistry, Peptide Coupling, Phosphonium/Uronium/Formamidinium, Synthetic Reagents

产品应用

  • BOP偶联试剂的类似物，但不形成致癌物HMPA为副产物。

相关文献及参考

  • Low racemization peptide coupling reagent (see Appendix 6), introduced by Castro, analogous to BOP Reagent (1H-Benzotriazol-1-yl­oxytris(dimethyl­amino)­phosphonium hexafluorophosphate, A16140) but avoiding the formation of the carcinogenic HMPA as a by-product: Tetrahedron Lett., 31, 205 (1990). For use in formation of mixed phosphonate diesters, see: J. Org. Chem., 60, 5214 (1995).
  • Low racemization peptide coupling reagent (see Appendix 6), introduced by Castro, analogous to BOP Reagent (1H-Benzotriazol-1-yl­oxytris(dimethyl­amino)­phosphonium hexafluorophosphate, A16140) but avoiding the formation of the carcinogenic HMPA as a by-product: Tetrahedron Lett., 31, 205 (1990). For use in formation of mixed phosphonate diesters, see: J. Org. Chem., 60, 5214 (1995).

安全信息

Warnings IRRITANT
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S37 Wear suitable gloves 戴适当手套；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Storage condition 2-8°C, sealed storage, away from moisture {LY} 2-8°C, sealed storage, away from moisture {} {LY} 2-8°C, sealed storage, away from moisture {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, seal
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P350
  • P302+P352+P332+P313+P362+P364
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P332+P313
  • P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
WGK Germany3
GHS Symbol
Signal word Warning
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Hazard Codes Xi
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves

系列性分类

  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Coupling - Synthetic Reagents
  4. Phosphonium/Uronium/Formamidinium - Coupling
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Chemicals by Class 化学分类法
  4. Halogenated 卤化物 (氟氯溴碘)
  5. Fluoro 氟化物
  1. Chemical Synthesis 化学合成
  2. Chemical Biology 生物化学
  3. Peptide Chemistry 多肽化学
  4. Peptide Coupling - Peptide Chemistry
  5. Phosphonium/Uronium/Formamidinium - Peptide Coupling

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