Cerulenin 变蓝菌素

CAS 17397-89-6 MFCD00077686

化学结构图

17397-89-6
SMILES: C/C=C/C/C=C/CCC(=O)[C@@H]1O[C@@H]1C(N)=O |&1:10,12|

化学属性

Mol. FormulaC12H17NO3
Mol. Weight223.30
TSCANo

别名和识别编码

Chemical NameCerulenin
Synonym (2R,3S,E,E)-2,3-Epoxy-4-oxo-7,10-dodecadienamide
MDL NumberMFCD00077686
Beilstein Registry Number4140423
EC Number241-424-8
PubChem Substance ID24892323
CAS Number17397-89-6
Merck Number14,2004
Chemical Name Translation变蓝菌素
Wiswesser Line NotationT3OTJ BVZ CV2U4U2
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分类

  • {SA} Antibiotics, Antibiotics A to Z, Antibiotics A-F, Antibiotics by Application, Antifungal, Antineoplastic and Immunosuppressive Antibiotics, Bioactive Small Molecules, C-CH, Cell Biology, Chemical Structure Class, Fatty Acid Derivatives, Inhibits an Enzyme, Mechanism of Action, Spectrum of Activity
  • {SNA} Antibiotics, Antibiotics A to Z, Antibiotics A-F, Antibiotics by Application, Antifungal, Antineoplastic and Immunosuppressive Antibiotics, Bioactive Small Molecules, Biochemicals and Reagents, C-CH, Cancer Metabolism, Cancer Research,

相关文献及参考

  • [2]. Tian D, et al. Overexpression of steroidogenic acute regulatory protein in rat aortic endothelial cells attenuates palmitic acid-induced inflammation and reduction in nitric oxide bioavailability. Cardiovasc Diabetol. 2012 Nov 21;11:144.
  • [3]. Cheng G, et al. Cerulenin blockade of fatty acid synthase reverses hepatic steatosis in ob/ob mice. PLoS One. 2013 Sep 27;8(9):e75980.
  • [1]. Bitencourt TA, et al. Trans-chalcone and quercetin down-regulate fatty acid synthase gene expression and reduce ergosterol content in the human pathogenic dermatophyte Trichophyton rubrum. BMC Complement Altern Med. 2013 Sep 17;13:229.
  • [1]. Bitencourt TA, et al. Trans-chalcone and quercetin down-regulate fatty acid synthase gene expression and reduce ergosterol content in the human pathogenic dermatophyte Trichophyton rubrum. BMC Complement Altern Med. 2013 Sep 17;13:229.
  • [2]. Tian D, et al. Overexpression of steroidogenic acute regulatory protein in rat aortic e

安全信息

GHS Symbol
WGK Germany3
Hazard statements
  • H302 Harmful if swallowed 吞食有害
RTECSJR1670000
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes Xn
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触;
Precautionary statements
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛,皮肤或衣服。
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 245 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al.,
   eds., Washington, DC, American Soc. for Microbiology, 1978
   Volume(issue)/page/year: 3,1945,1978

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 211 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JAJAAA Journal of Antibiotics, Series A.  (Tokyo, Japan)  V.6-20, 1953-67.
   For publisher information, see JANTAJ.  Volume(issue)/page/year: 17,1,1964

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 547 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JAJAAA Journal of Antibiotics, Series A.  (Tokyo, Japan)  V.6-20, 1953-67.
   For publisher information, see JANTAJ.  Volume(issue)/page/year: 17,1,1964

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 154 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JAJAAA Journal of Antibiotics, Series A.  (Tokyo, Japan)  V.6-20, 1953-67.
   For publisher information, see JANTAJ.  Volume(issue)/page/year: 17,1,1964

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 2 mg/L
REFERENCE :
   JOBAAY Journal of Bacteriology.  (American Soc. for Microbiology, 1913 I
   St., NW, Washington, DC 20006)  V.1-    1916-  Volume(issue)/page/year:
   133,472,1978

系列性分类


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