Digitonin 洋地黄皂苷

CAS 11024-24-1 MFCD00077729

化学结构图

11024-24-1
SMILES: C[C@H]1[C@H]2[C@@H](O[C@]13CC[C@@H](C)CO3)[C@@H](O)[C@H]1[C@@H]3CC[C@H]4C[C@@H](O[C@@H]5O[C@H](CO)[C@H](O[C@@H]6O[C@H](CO)[C@@H](O)[C@H](O[C@@H]7OC[C@@H](O)[C@H](O)[C@H]7O)[C@H]6O[C@@H]6O[C@H](CO)[C@H](O)[C@H](O[C@@H]7O[C@H](CO)[C@@H](O)[C@H](O)[C@H]7O)[C@H]6O)[C@H](O)[C@H]5O)[C@H](O)C[C@]4(C)[C@H]3CC[C@@]12C

化学属性

Mol. FormulaC56H92O29
Mol. Weight1229.31
Melting Point230-240
Density1.59
Danger-Level-
pH-:-
Redox-

别名和识别编码

Chemical NameDigitonin
Synonym Digitin Digitonin 毛地黃皂苷 毛地黄皂甙,洋地黄皂甙 毛地黄皂苷
CAS Number11024-24-1
PubChem Substance ID87567200
EC Number234-255-6
Beilstein Registry Number78654
MDL NumberMFCD00077729
Reaxys-RN78654
Merck Number3161
Chemical Name Translation洋地黄皂苷
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分类

  • {SNA} non-ionic
  • {SNA} Cell Culture, Cell Lysis Reagents, Conjugates, Core Bioreagents, Detergents, Detergents A to M, Detergents by Applications, Diagnostic Applications, Electrophoresis Chromatography, Enzymology, Membrane Protein Solubilization, Molecular Biology, Non-Ionic Detergents, Research Essentials, Signal Transduction Research Tools, Sterol Lipids, 去垢剂, 生化试剂, 细胞信号转导和神经科学, 细胞生物学, 脂类
  • {SNA} Cell Cul
  • {SNA} Cell Culture, Cell Lysis Reagents, Conjugates, Core Bioreagents,

产品应用

  • ⑴. 可燃, 火场排出辛辣刺激烟雾。
  • ⑵. 利用沉淀反应测定血浆、胆汁和组织中的胆甾醇。
  • ⑶. 用作较高级醇类和酚类、硫酚类的试剂。
  • ⑷. 在生化研究中可作为去垢剂和脱溶剂处理分离的线粒体，溶解线粒体外膜。
  • 利用沉淀反应测定血浆、胆汁核组织的胆甾醇。也用作较高级醇类核酚类、硫酚类的试剂。

相关文献及参考

  • Merck: 14,3161 Beilstein:19(3/4)1243
  • Merck 14 ,3161
  • Prehm, S., et al., A mild purification method for polysaccharide binding membrane proteins: phase separation of digitonin extracts to isolate the hyaluronate synthase from Streptococcus sp. in active form. Protein Expr. Purif. 7 , 343-346, (1996) 摘要
  • Liu, J., et al., Use of digitonin-permeabilized cells in studies of steroid receptor subnuclear trafficking. Methods 19 , 403, (1999) 摘要
  • Nock, B., Extracti-Gel D chromatography is a simple efficient method for removing digitonin during receptor purification: application to the κ 1 opioid receptor. J. Neurosci. Methods 50 , 353, (1993) 摘要

安全信息

GHS Symbol
WGK Germany3
Hazard Codes 6.1 T
Hazard statements
  • H301+H311+H331
  • H330 Fatal if inhaled 吸入致命
  • H311 Toxic in contact with skin 皮肤接触中毒
  • H301 Toxic if swallowed 吞食有毒
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
RTECSIH2050050
Precautionary statements
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P301+P310+P330
  • P302+P352+P312+P361+P364
  • P304+P340+P311
  • P305+P351+P338
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P405 Store locked up. 上锁保管。
Signal word Danger
UN Number 3462
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘；
  • S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
Risk Statements
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Packing GroupIII
Hazard Class6.1 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 90 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig,
   Ger. Dem. Rep.)  Volume(issue)/page/year: 4,1289,1935

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig,
   Ger. Dem. Rep.)  Volume(issue)/page/year: 4,1289,1935

TYPE OF TEST            : LD10 - Lethal Dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 20 mg/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   PCJOAU Pharmaceutical Chemistry Journal (English Translation).  Translation
   of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)  No.1-
   1967-  Volume(issue)/page/year: 11,749,1977

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 12,815,1962

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >50 mg/kg
TOXIC EFFECTS :

{ha

TYPE OF TEST            : Sex chromosome loss and nondisjunction
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 250 ppb
REFERENCE :
   ANYAA9 Annals of the New York Academy of Sciences.  (New York Academy of
   Sciences, 2 E. 63rd St., New York, NY 10021)  V.1-    1877-
   Volume(issue)/page/year: 407,186,1983

Restrict -

其他信息

  • ⑴. 该物质对环境可能有危害，对水体应给予特别注意。

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  1. Application Areas 应用领域分类
  2. Detergents 去污剂洗净剂
  3. Non-Ionic Detergents - Detergents
  1. Application Areas 应用领域分类
  2. Detergents 去污剂洗净剂
  3. Non-Ionic Detergents - Detergents
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Lipids - Biochemicals and Reagents
  4. Sterol Lipids - Lipids
  5. Conjugates - Sterol Lipids
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Others 其他杂环
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Others 其他杂环
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Signal Transduction Research Tools - Cell Signaling and Neuroscience
  5. Cell Lysis Reagents - Signal Transduction Research Tools
  6. Detergents - Cell Lysis Reagents
  1. Life Science 生命科学
  2. Biochemistry / Glyco-Chemistry
  3. Steroids
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymatic Cell Lysis and Protoplast Preparation
  4. Bacterial
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Signal Transduction Research Tools
  5. Cell Lysis Reagents
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Lipids
  4. Sterols
  5. Cholesterol and Derivatives

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