5-(N-METHYL-N-ISOBUTYL)AMILORIDE

CAS 96861-65-3 MFCD00078567

化学结构图

96861-65-3
SMILES: CN(C1=NC(N)=C(N=C1Cl)C(=O)NC(N)=N)C(C)(C)C

化学属性

Mol. FormulaC11H18ClN7O
Mol. Weight299.76

别名和识别编码

Chemical Name5-(N-Methyl-N-isobutyl)­amiloride
Synonym MIA
MDL NumberMFCD00078567
PubChem Substance ID24278228
CAS Number96861-65-3
Chemical Name Translation
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

分类

  • {SA} A to C, Adenosinetriphosphatase (Na/K), Amiloride and Derivatives, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme,
  • {SNA} A to C, Adenosinetriphosphatase (Na/K), Amiloride and Derivatives, Bioactive Small Molecule Alphabetical Index, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Ion Channels, M, Monovalent Ion Channels, Sodium Channel Modulators, Voltage-gated Ion Channels, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学, 酶、抑制剂和底物

相关文献及参考

  • Maidorn, R.P., et al. Br. J. Cancer 67 , 297, (1993) 摘要
  • Xiao, X.H., Allen, D.G. Circ. Res. 85 , 723, (1999) 摘要
  • Lauro, K.L., et al. Brain Res. 831 , 64, (1999) 摘要
  • Coaxum, S.D., et al., Epidermal growth factor activates Na + /H + exchanger in podocytes through a mechanism that involves Janus kinase and calmodulin Biochim. Biophys. Acta 1793 , 1174-81, (2009)
  • Tseng, I.C., et al., Matriptase activation, an early cellular response to acidosis J. Biol. Chem. 285 , 3261-70, (2010)
  • Hughes, A.L., et al., Regulatory volume increase in epithelial cells isolated from the mouse fourth ventricle choroid plexus involves Na(+)-H(+) exchange but not Na + -K + -2Cl - cotransport Brain Res. 1323 , 1-10, (2010)

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
Signal word Warning
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Hazard Codes Xi
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Enzyme - Enzyme Inhibitors
  6. A to C - Enzyme Inhibitors by Enzyme
  7. Adenosinetriphosphatase (Na/K) - A to C
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Ion Channels - Cell Signaling and Neuroscience
  5. Voltage-gated Ion Channels - Ion Channels
  6. Monovalent Ion Channels - Voltage-gated Ion Channels
  7. Sodium Channel Modulators - Monovalent Ion Channels
  8. Amiloride and Derivatives - Sodium Channel Modulators

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