Fusarenon X solution 镰刀菌烯酮-X 溶液

CAS 23255-69-8 MFCD00078778

化学结构图

23255-69-8
SMILES: C[C@]12[C@@H](OC(C)=O)[C@H](O)[C@H](O[C@H]3C=C(C)C(=O)C(O)[C@@]13CO)[C@@]12CO1

化学属性

Mol. FormulaC17H22O8
Mol. Weight354.35

别名和识别编码

Chemical NameFusarenon X solution
CAS Number23255-69-8
Synonym 3-Acetylnivalenol 3α,7α,15-Trihydroxy-4β-acetoxy-12,13-epoxytrichothec-9-en-8-one FusX 4?-Acetoxy-3?,7?,15-trihydroxy-12,13-epoxytrichothec-9-en-8-one 12,13-Epoxy-3-alpha,4-beta,7-beta,15-tetrahydroxytrichothec-9-en-8-one Nivalenol Monoacet (3?,4?,7?)-4-(Acetyloxy)-12,13-epoxy-3,7,15-trihydroxy-trichothec-9-en-8-one 4-Acetyloxy-12,13-epoxy-3,7,15-trihydroxy-(3-alpha,4-beta,7-beta)-trichothec-9-en-8-one 4-Acetylnivalenol 镰刀菌烯酮-X 溶液 3α,7α,15-Trihydroxy-4β-acetoxy-12,13-epoxytrichothec-9-en-8-one
PubChem Substance ID24860924
EC Number200-835-2
MDL NumberMFCD00078778
Wiswesser Line NotationT C665 A AX EV IO FUTJ B1 C1Q DQ F1 KQ LOV1 A-& BT3OXCHJ
Chemical Name Translation镰刀菌烯酮-X 溶液
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分类

  • Analytical Standards, Analytical/Chromatography, Application CRMs, Biotoxins, CRM & Matrix RM, Certified Reference Materials (CRMs), Chromatography, Food and Agriculture CRM, Life Sciences Standards, Mycotoxins, Neat, Other
  • {SNA} All alphabetically sorted, Alphabetic, Analytical Standards, Analytical/Chromatography, Biotoxins, Chromatography, F, FM - FZ, Life Sciences Standards, Mycotoxins, Single component solutions
  • {SNA} All alphabetically sorted, Analytical Standards, Biotoxin and Mycotoxin Standards,

产品应用

  • A mycotoxin produced by Fusarium, having immunosuppressive and carcinogenic properties.

相关文献及参考

  • Alvarez, C., et al.: Int. J. Food Microbiol., 135, 131 (2009),

安全信息

Hazard Codes F,Xn T+
RTECSYD0160000
GHS Symbol
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P301+P310
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
Signal word Danger
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H300 Fatal if swallowed 吞食致命
  • H332 Harmful if inhaled 吸入有害
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
  • H312 Harmful in contact with skin 皮肤接触有害
  • H302 Harmful if swallowed 吞食有害
WGK Germany2
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Risk Statements
  • R11 Highly flammable 非常易燃
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
  • R36 Irritating to eyes 刺激眼睛
Safety Statements
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
  • S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
Restrict 剧毒化学品
Warnings 危化品目录(2015) 危险化学品 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 153 mg/kg/1Y-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Endocrine - tumors
   Endocrine - thyroid tumors
REFERENCE :
   JJEMAG Japanese Journal of Experimental Medicine.  (Kinokuniya Book-Stores
   of America Co., Ltd., West Bldg., Japan Cultural and Trade Center, 1581
   Webster St., San Francisco, CA 94115) V.7-    1928- Volume(issue)/page/year:
   50,293,1980

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 146 mg/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Endocrine - tumors
   Endocrine - thyroid tumors
REFERENCE :
   JJEMAG Japanese Journal of Experimental Medicine.  (Kinokuniya Book-Stores
   of America Co., Ltd., West Bldg., Japan Cultural and Trade Center, 1581
   Webster St., San Francisco, CA 94115) V.7-    1928- Volume(issue)/page/year:
   50,293,1980

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 22750 ug/kg/1Y-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Liver - tumors
   Reproductive - Tumorigenic effects - uterine tumors
REFERENCE :
   MAIKD3 Maikotokishin (Tokyo).  Mycotoxin.  (Maikotokishin Kenkyukai, c/o
   Tokyo Rika Daigaku Yakugakubu, 12 Funagawara-machi, Ichigaya, Shinjuku-ku,
   Tokyo 162, Japan)  No.1-    1975-  Volume(issue)/page/year: (21),38,1985

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle weakness
   Gastrointestinal - hypermotility, diarrhea
   Gastrointestinal - other changes
REFERENCE :
   JJEMAG Japanese Journal of Experimental Medicine.  (Kinokuniya Book-Stores
   of America Co., Ltd., West Bldg., Japan Cultural and Trade Center, 1581
   Webster St., San Francisco, CA 94115) V.7-    1928- Volume(issue)/page/year:
   41,521,1971

TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >4 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   34ZHAD "Symposium on Mycotoxins in Human Health," Purchase, I.F.H., London,
   Macmillan, 1971  Volume(issue)/page/year: -,163,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3400 ug/kg
TOXIC EFFECTS :
   Behavioral - food intake (animal)
   Behavioral - fluid intake
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   JJEMAG Japanese Journal of Experimental Medicine.  (Kinokuniya Book-Stores
   of America Co., Ltd., West Bldg., Japan Cultural and Trade Center, 1581
   Webster St., San Francisco, CA 94115) V.7-    1928- Volume(issue)/page/year:
   41,521,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 500 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DFSCDX Developments in Food Science.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 100

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Human HeLa cell
DOSE/DURATION           : 32 mg/L/1H
REFERENCE :
   JJEMAG Japanese Journal of Experimental Medicine.  (Kinokuniya Book-Stores
   of America Co., Ltd., West Bldg., Japan Cultural and Trade Center, 1581
   Webster St., San Francisco, CA 94115) V.7-    1928- Volume(issue)/page/year:
   42,527,1972

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 250 mg/L
REFERENCE :
   JJEMAG Japanese Journal of Experimental Medicine.  (Kinokuniya Book-Stores
   of America Co., Ltd., West Bldg., Japan Cultural and Trade Center, 1581
   Webster St., San Francisco, CA 94115) V.7-    1928- Volume(issue)/page/year:
   41,521,1971

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 2100 ug/kg
SEX/DURATION            : female 1-7 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Fertility - abortion
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   JJEMAG Japanese Journal of Experimental Medicine.  (Kinokuniya Book-Stores
   of America Co., Ltd., West Bldg., Japan Cultural and Trade Center, 1581
   Webster St., San Francisco, CA 94115) V.7-    1928- Volume(issue)/page/year:
   50,167,1980

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 1 mg/kg
SEX/DURATION            : female 10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   JJEMAG Japanese Journal of Experimental Medicine.  (Kinokuniya Book-Stores
   of America Co., Ltd., West Bldg., Japan Cultural and Trade Center, 1581
   Webster St., San Francisco, CA 94115) V.7-    1928- Volume(issue)/page/year:
   50,167,1980

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 2400 ug/kg
SEX/DURATION            : female 7-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   JJEMAG Japanese Journal of Expe

系列性分类

  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Life Sciences Standards - Chromatography
  5. Biotoxins - Life Sciences Standards
  6. Mycotoxins - Biotoxins
  7. Neat - Mycotoxins
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. F - Alphabetic
  5. FM - FZ - F
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Life Sciences Standards - Chromatography
  5. Biotoxins - Life Sciences Standards
  6. Mycotoxins - Biotoxins
  7. Alphabetical sorted - Mycotoxins

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