Bendroflumethiazide 苄氟噻嗪

CAS 73-48-3 MFCD00078963

化学结构图

73-48-3
SMILES: NS(=O)(=O)c1cc2c(cc1C(F)(F)F)NC(Cc1ccccc1)NS2(=O)=O

化学属性

Mol. FormulaC₁₅H₁₄F₃N₃O₄S₂
Mol. Weight421.41
Melting Point205-207°C
Boiling Point-
Flash Point-

别名和识别编码

Chemical Namerac Bendroflumethiazide
Synonym 3-Benzyl-3,4-dihydro-6-(trifluoromethy)-2H-1,2,4-benzothiadiazine-7-sulfonamide-1,1-dioxide 3-Benzyl-3,4-dihydro-6-(trifluoromethyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide 3-Benzyl-6-trifluoromethyl-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine, 1,1-dioxide 3-苄基-6-三氟甲基-7-氨磺酰-3,4-二氢-2H-1,2,4-苯并噻二嗪-1,1-二氧化物 6-Trifluoromethyl-3-benzyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine, Aprinox BHFT BL H368 Be 724-A Bendrofluazide Bendroflumethiazide Bentride Benuron Benzide Benzide M Benzide-M Benzydroflumethiazide Benzylhydroflumethiazide Benzylrodiuran Berkozide Bristuric Bristuron Centyl Esberizid FT 8 Flumesil Intolex {PubCh
MDL Number-
PubChem Substance ID2315
CAS Number73-48-3
EC Number200-800-1
Chemical Name Translation苄氟噻嗪
InChIKeyHDWIHXWEUNVBIY-UHFFFAOYSA-N
Wiswesser Line NotationT66 BSWM EM DHJ D1R& HXFFF ISZW
Beilstein Registry Number0373316
LabNetwork Molecule IDLN00195770
InChIInChI=1S/C15H14F3N3O4S2/c16-15(17,18)10-7-11-13(8-12(10)26(19,22)23)27(24,25)21-14(20-11)6-9-4-2-1-3-5-9/h1-5,7-8,14,20-21H,6H2,(H2,19,22,23)
Canonical SMILES-
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分类

  • Alphabetic, Analytical Standards, Analytical/Chromatography, B, BA - BH, Chromatography, Diuretic, Doping Substances, Drugs & Metabolites, Forensic and Veterinary Standards, Neat Compounds
  • {SNA} All Doping Standards (A-Z), Alphabetic, Analytical Standards, Analytical/Chromatography, B, BA - BH, Chromatography, Diuretic, Doping Substances, Drugs & Metabolites, Forensic and Veterinary Standards, Neat Compounds

相关文献及参考

  • Merck 14 ,1037

安全信息

RTECSDK8225000
WGK Germany2
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4800 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
   Pharmakologie.  (Berlin, Ger.) V.110-253, 1925-66.  For publisher
   information, see NSAPCC.  Volume(issue)/page/year: 238,435,1960

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >10 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,781,1982

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 300 ug/kg/3D-I
TOXIC EFFECTS :
   Nutritional and Gross Metabolic - changes in sodium
REFERENCE :
   LANCAO Lancet.  (7 Adam St., London WC2N 6AD, UK)  V.1-    1823-
   Volume(issue)/page/year: 2,634,1986

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 395 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 134,273,1961

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 200 mg/L
REFERENCE :
   GMCRDC Gann Monograph on Cancer Research.  (Plenum Pub. Corp., 233 Spring
   St., New York, NY 10013) No. 11-    1971-  Volume(issue)/page/year:
   27,95,1981

Hazard statements
Storage condition 4°C

系列性分类


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