Cyclobenzaprine Hydrochloride 盐酸环苯扎林
CAS 6202-23-9 MFCD00079039
化学结构图
SMILES: CN(C)CCC=C1c2ccccc2C=Cc2ccccc21.Cl
化学属性
| Mol. Formula | C20H22ClN |
|---|---|
| Mol. Weight | 312 |
| Melting Point | 217 |
别名和识别编码
| Chemical Name | Cyclobenzaprine Hydrochloride |
|---|---|
| MDL Number | MFCD00079039 |
| CAS Number | 6202-23-9 |
| Synonym | 1-Prop 3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)propyl(dimethyl)ammonium chloride 3-(5h-dibenzo(a,d)cyclohepten-5-ylidene)-n,n-dimethyl-1-propanaminhydroc 5-(3-Dimethylaminopropylidene)dibenzo[a,e]cycloheptatriene hydrochloride CYCLOBENZAPRINE HYDROCHLORIDE CYCLOBENZAPRINEHYDROCHLORIDE,USP Cyclobenzaprine hydrochloride Flexiba N,N-Dimethyl-5H-dibenzo(a,d)cycloheptene-delta(sup 5,gamma)-propylamine d)cycloheptene-delta(sup5)-gamma-propylamine,n,n-dimethyl-5h- n,n-dimethyl-5h-dibenzo(a,d)cycloheptene-delta(sup5,gamma)-propylaminehydro 环苯扎啉 |
| PubChem Substance ID | 253661206 |
| EC Number | 228-264-4 |
| Chemical Name Translation | 盐酸环苯扎林 |
| Wiswesser Line Notation | L C676 BHJ B3N1&1 &GH |
| Beilstein Registry Number | 6247987 |
| Reaxys-RN | 6247987 |
| Merck Number | 2713 |
| LabNetwork Molecule ID | LN00201418 |
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分类
- {SNA} Antagonists,
- {SNA} Antagonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Biochemicals and Reagents, CI-CY, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Johnson & Johnson, Membrane Protein Biology Tools, Neuroscience, Neurotransmission, Neurotransmitters, Proteins and Derivatives, Serotonergics, Serotonergics - Antagonists, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
- {SNA} Antagonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, CI-CZ, GPCR Modulators, GPCR Proteins, Modulators and Antibodies,
- {SNA} Antagonists,
相关文献及参考
- [2]. Honda, M., T. Nishida, and H. Ono, Tricyclic analogs cyclobenzaprine, amitriptyline and cyproheptadine inhibit the spinal reflex transmission through 5-HT(2) receptors. Eur J Pharmacol, 2003. 458(1-2): p. 91-9.
- [1]. Kobayashi, H., Y. Hasegawa, and H. Ono, Cyclobenzaprine, a centrally acting muscle relaxant, acts on descending serotonergic systems. Eur J Pharmacol, 1996. 311(1): p. 29-35.
- [1]. Kobayashi, H., Y. Hasegawa, and H. Ono, Cyclobenzaprine, a centrally acting muscle relaxant, acts on descending serotonergic systems. Eur J Pharmacol, 1996. 311(1): p. 29-35.
- [2]. Honda, M., T. Nishida, and H. Ono, Tricyclic analogs cyclobenzaprine, amitriptyline and cyproheptadine inhibit the spinal reflex transmission through 5-HT(2) receptors. Eur J Pharmacol, 2003. 458(1-2): p. 91-9.
安全信息
GHS Symbol
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P301+P310
- P301+P310+P330
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- H301 Toxic if swallowed 吞食有毒
- H312+H332
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE/DURATION : 5714 ug/kg/2D-I TOXIC EFFECTS : Behavioral - wakefulness Behavioral - euphoria Behavioral - hallucinations, distorted perceptions REFERENCE : JCLPDE Journal of Clinical Psychiatry. (Physicians Postgraduate Press, Inc., POB 240008, Memphis, TN 38124) V.39- 1978- Volume(issue)/page/year: 54,39,1993
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 36 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 144,481,1963
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 8400 ug/kg/2W-I TOXIC EFFECTS : Behavioral - general anesthetic REFERENCE : JCLPDE Journal of Clinical Psychiatry. (Physicians Postgraduate Press, Inc., POB 240008, Memphis, TN 38124) V.39- 1978- Volume(issue)/page/year: 44,151,1983
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 1 mg/kg/3D-I TOXIC EFFECTS : Behavioral - wakefulness Behavioral - euphoria Behavioral - hallucinations, distorted perceptions REFERENCE : JCLPDE Journal of Clinical Psychiatry. (Physicians Postgraduate Press, Inc., POB 240008, Memphis, TN 3
其他信息
- MOL 文件:6202-23-9.mol
- Sigma Aldrich:6202-23-9(sigmaaldrich)
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