sodium (2Z)-N-((6R,7R)-3-(acetoxymethyl)-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-7-yl)-2-(2-imino-2,3-dihydrothiazol-4-yl)-2-(methoxyimino)acetimidate 头孢噻肟钠

CAS 64485-93-4 MFCD00079073

化学结构图

64485-93-4
SMILES: [Na+].CC(=O)OCC1CS[C@@H]2[C@H](NC(=O)/C(=N\OC)/C3=CSC(N)=N3)C(=O)N2C=1C([O-])=O |&1:9,10|

化学属性

Mol. FormulaC16H16N5NaO7S2
Mol. Weight477
Melting Point163

别名和识别编码

Chemical Namesodium (2Z)-N-((6R,7R)-3-(acetoxymethyl)-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-7-yl)-2-(2-imino-2,3-dihydrothiazol-4-yl)-2-(methoxyimino)acetimidate
CAS Number64485-93-4
Synonym Cefotaxime sodium salt 钠盐
PubChem Substance ID24892923
EC Number264-915-9
Beilstein Registry Number5711411
MDL NumberMFCD00079073
Reaxys-RN6564218
Merck Number1933
Chemical Name Translation头孢噻肟钠
Wiswesser Line NotationT46 ANV ES GUTJ G1OV1 HVO CMVYUNO1&- ET5N CSJ BZ&-NA-
LabNetwork Molecule IDLN01264947
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

分类

  • A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics A-F, Antibiotics and Antimycotics, Chemical Structure Class, Interferes with Cell Wall Synthesis, Mechanism of Action, Penicillins and Cephalosporins (beta-Lactams), Plant Biotechnology, Plant Tissue Culture, Spectrum of Activity
  • {SNA} 1694 Pharmaceuticals & Personal Care Products, A - K, Analytical Standards, Analytical/Chromatography, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics A-F, Biochemicals and Reagents, Chemical Structure Class, EPA, Interferes with

产品应用

  • Broad spectrum third generation cephalosporin antibiotic. The name Cefotaxime applies to the isomer having a syn-methoxy imino group.

相关文献及参考

  • Wise, R., et al.: Antimicrob. Agents Chemother., 14, 807 (1978),
  • Muhtadi, F.J., et al.: Anal. Profiles Drug Subs., 11, 139 (1982),
  • Kumar J, Shukla SM, Bhat V, et al., In vitro plant regeneration and genetic transformation of Dichanthium annulatum. DNA Cell. Biol. 24 , 670-679, (2005) 摘要
  • Yookongkaew N, Srivatanakul M, Narangajavana J., Development of genotype-independent regeneration system for transformation of rice (Oryza sativa ssp. indica). J. Plant Res. 120 , 237-245, (2007) 摘要
  • Mhatre M, Srinivas L, Ganapathi TR., Enhanced Iron and Zinc Accumulation in Genetically Engineered Pineapple Plants Using Soybean Ferritin Gene. Biol. Trace Elem. Res. , (2011)
  • Merck 14 ,1933

安全信息

GHS Symbol
WGK Germany2
Hazard Codes Xn
Hazard statements
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
RTECSXI0250000
Precautionary statements
  • P285 In case of inadequate ventilation wear respiratory protection. 在通风不足的情况下,戴呼吸防护。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P302+P352+P333+P313+P362+P364
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P342+P311
  • P333+P313
  • P304+P341
  • P302+P350
Signal word
Safety Statements
Risk Statements
  • R42/43
Storage condition 0-10 0-10°C
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 6845 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ANKHEW Antibiotiki i Khimioterapiya.  Antibiotics and Chemotherapy. (V/O Me
   zhdunarodnaya Kniga, 113095 Moskow, USSR)  V.33-    1988-
   Volume(issue)/page/year: 35(5),25,1990

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 10 gm/kg
TOXIC EFFECTS :
   Behavioral - food intake (animal)
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   NKRZAZ Chemotherapy (Tokyo).  (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
   Shinagawa-Ku, Tokyo 141, Japan)  V.1-    1953- Volume(issue)/page/year:
   28(Suppl 1),98,1980

TYPE OF TEST            :

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 18400 mg/kg
TOXIC EFFECTS :
   Behavioral - food intake (animal)
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   NKRZAZ Chemotherapy (Tokyo).  (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
   Shinagawa-Ku, Tokyo 141, Japan)  V.1-    1953- Volume(issue)/

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >20 gm/kg
TOXIC EFFECTS :
   Behavioral - food intake (animal)
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   NKRZAZ Chemotherapy (Tokyo).  (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
   Shinagawa-Ku, Tokyo 141, Japan)  V.1-    1953- Volume(issue)/pag

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 325 mg/kg
SEX/DURATION            : female 6-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 21,375,1981

系列性分类


相关产品推荐