Doxepin Hydrochloride 盐酸多塞平

CAS 1229-29-4 MFCD00079135

化学结构图

1229-29-4
SMILES: CN(C)CCC=C1c2ccccc2COc2ccccc21.Cl

化学属性

Mol. FormulaC19H22ClNO
Mol. Weight315.84
TSCANo
Melting Point186.0 to 190.0 deg-C
Solubility1 M HCl: 50 mg/mL
Appearance powder

别名和识别编码

Chemical NameDoxepin Hydrochloride
CAS Number1229-29-4
MDL NumberMFCD00079135
Synonym 1-Propanamine, 3-dibenzb,eoxepin-11(6H)-ylidene-N,N-dimethyl-, hydrochloride 11-(3-(Dimethylamino)propylidene)-6,11-dihydrodibenz(b,e)oxepin 11-(3-DIMETHYLAMINOPROPYLIDENE)-6,11-DIHYDRODIBENZ[B,E]OXEPIN HYDROCHLORIDE 11-(3-Dimethylaminopropylidene)-6,11-dihydro-benz[b,e]Oxepin 11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepine hydrochloride 11-(3-dimethylaminopropylidene)-6,11-dihydro-benz[b,e]oxepin 11-(3-dimethylaminopropylidene)-6,11-dihydro-benz[b,e]oxepin hcl 11-Dimethylamino propylidene 6H-dibenz(b,e)oxepin 11-dimethylaminopropylidene6h-dibenz(b,e)oxepin 11[16H]-[3-(DIMETHYLAMINO)-PROPYLIDENE]DIBENZ[B,E]OXEPINE HYDROCHLORIDE 3-(6,11-dihydrodibenz(b,e)oxepin-11-ylidene)propyldimethylamine hcl 3-DIBENZ(B,C)OXEPIN 11(6H)YLIDENE-N,N-DIMETHYL-1-PROPANAMINE HYDROCHLORIDE 3-dibenz(b,e)ox
PubChem Substance ID6419921
EC Number214-966-8
Merck Number3435
Chemical Name Translation盐酸多塞平
Wiswesser Line NotationT C676 IO&T&J B3N1&1 &GH
Reaxys-RN5463221
InChIInChI=1S/C19H21NO.ClH/c1-20(2)13-7-11-17-16-9-4-3-8-15(16)14-21-19-12-6-5-10-18(17)19;/h3-6,8-12H,7,13-14H2,1-2H3;1H/b17-11+;
Canonical SMILESCN(C)CC/C=C1C2=CC=CC=C2OCC3=CC=CC=C/13.Cl
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分类

  • {SNA} Analytical S
  • {SNA} Approved Therapeutics/D
  • {SNA} Analytical Standards, Chromatography, EP Standards, EP Standards C - D, Pharmaceutical Standards, Pharmacopeia Standards, 分析/色谱
  • {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Biochemicals and Reagents, Biogenic Amine Transport Inhibitors, Boehringer Ingelheim, Cell Signaling and Neuroscience, DIG-DY, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Protein Biology Tools, Neuroscience, Neurotransmission, Neurotransmission (Obesity), Neurotransmitters, Obesity Research, Proteins and Derivatives, 细胞生物学

相关文献及参考

  • [2]. Hajak, G., et al., Doxepin in the treatment of primary insomnia: a placebo-controlled, double-blind, polysomnographic study. J Clin Psychiatry, 2001. 62(6): p. 453-63.
  • [1]. http://pdsp.med.unc.edu/pdsp.php
  • [1]. http://pdsp.med.unc.edu/pdsp.php
  • [2]. Hajak, G., et al., Doxepin in the treatment of primary insomnia: a placebo-controlled, double-blind, polysomnographic study. J Clin Psychiatry, 2001. 62(6): p. 453-63.

安全信息

GHS Symbol
WGK Germany3
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
RTECSHQ4375000
Precautionary statements
  • P301+P310+P330
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P405 Store locked up. 上锁保管。
  • P301+P310
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
Signal word Danger
Safety Statements
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S20 When using do not eat or drink 使用时,不得进食,饮水;
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
Hazard Codes T
Risk Statements
  • R25 Toxic if swallowed 吞咽有毒
  • R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
Packing GroupIII
UN Number UN 2811 6.1/PG 3 UN2811 2811
Hazard Class6.1
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 15 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
   D.H. Efron, Washington, DC, 1972  Volume(issue)/page/year: -,72,1972

TYPE OF TEST            : TDLo - Lowe

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : >27 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
   Behavioral - convulsions or effect on seizure threshold
   Gastrointestinal - nausea or vomiting
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 6,889,1972

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 40 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
   Behavioral - convulsions or effect on

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 155 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 6,889,1972

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 60 mg/kg
SEX/DURATION            : female 9-14 day(s) after conception
TOXIC

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1620 mg/kg
SEX/DURATION            : female 9-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - live birth index (measured after birth)
   Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
   alive at weaning per # alive at day 4)
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 5,913,1971

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 210 mg/kg
SEX/DURATION            : female 8-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - live birth index (measured after birth)
REFERENCE :
   DPTHDL Developmental Pharmacology and Therapeutics.  (S. Karger Pub., Inc.,
   79 Fifth Ave., New York, NY 10003)  V.1-    1980-  Volume(issue)/page/year:
   8,17,1985

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 45 mg/kg
SEX/DURATION            : female 8-16 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volu

Storage condition 2-8°C 2-8°C, sealed storage, away from moisture

其他信息

  • 毒性分级:高毒
  • 用途一:抗抑郁症,用于抑郁症及神经官能症。
  • color:white to off-white
  • 储运特性:库房通风低温干燥; 与食品原料分开存放
  • 灭火剂:干粉、泡沫、砂土、二氧化碳, 雾状水
  • MOL 文件:1229-29-4.mol
  • 可燃性危险特性:可燃;燃烧释放有毒氮氧化物,氯化氢烟雾; 药物副作用: 幻想,偏见,肌肉痉挛,心跳改变,耳鸣
  • 急性毒性:口服-大鼠 LD50: 147 毫克/公斤; 口服-小鼠 LD50: 180 毫克/公斤
  • Sigma Aldrich:1229-29-4(sigmaaldrich)
  • 类别:有毒物品

系列性分类


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