Phentolamine Hydrochloride 盐酸苯酚胺
CAS 73-05-2 MFCD00079268
化学结构图
SMILES: Cc1ccc(N(CC2=NCCN2)c2cccc(O)c2)cc1.Cl
化学属性
| Mol. Formula | C17H20ClN3O |
|---|---|
| Mol. Weight | 318 |
别名和识别编码
| Chemical Name | Phentolamine Hydrochloride |
|---|---|
| CAS Number | 73-05-2 |
| Synonym | Regitine Hydrochloride C-7337 3-(((4,5-Dihydro-1H-imidazol-2-yl)methyl)(4-methylphenyl)amino)phenol 2-[N-(3-Hydroxyphenyl)-p-toluidinomethyl]-2-imidazolidine hydrochloride 3-[[(4,5-Dihydro-1H-imidazol-2-yl)-methyl](4-methylphenyl)-amino]-phenol monohydrochloride 3-[4,5-Dihydro-1H-imidazol-2-ylmethyl-(4-methylphenyl)amino]phenol hydrochloride 2-[N-(3-Hydroxyphenyl)-p-toluidinomethyl]-2-imidazolidine hydrochloride 酚妥拉明 盐酸盐 2-[N-(m-Hydroxyphenyl)-p-toluidinomethyl]imidazoline Hydrochloride 盐酸酚妥拉明 3-[[(4,5-Dihydro-1H-imidazol-2-yl)methyl](4-methylphenyl)amino]-phenol Hydrochloride 3-[[(4,5-Dihydro-1H-imidazol-2-yl)-methyl](4-methylphenyl)-amino]-phenol monohydrochloride DNP |
| MDL Number | MFCD00079268 |
| Beilstein Registry Number | 3764617 |
| EC Number | 200-793-5 |
| PubChem Substance ID | 5702144 |
| Chemical Name Translation | 盐酸苯酚胺 |
| LabNetwork Molecule ID | LN00676074 |
| InChI | InChI=1S/C17H19N3O.ClH/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15;/h2-8,11,21H,9-10,12H2,1H3,(H,18,19);1H |
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分类
- {SNA} Adrenergics, Adrenergics - Antagonists, Antagonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index,
- Heterocycles
- {SNA} Adrenergics, Adrenergics - Antagonists, Antagonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Fluorination Ready Pharma-Developed Compounds, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Protein Biology Tools, Neuroscience, Neurotransmission, Neurotransmitters, Novartis, P-PH, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学, 蛋白质及衍生物
- Diagnostic
产品应用
- An adrenergic blocking agent. An antihypertensive. Used for the treatment of pheochromocytoma.
相关文献及参考
- Meier, R., et al.: Proc. Soc. Exp. Biol. Med., 71, 70 (1949),
- Spergel, G., et al.: J. Am. Med. Assoc., 211, 266 (1970),
安全信息
GHS Symbol
WGK Germany3
Hazard statements
- H302 Harmful if swallowed 吞食有害
RTECSSL0701000
Signal word
Warning
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes
Xn
Safety Statements
- S22 Do not breathe dust 不要吸入粉尘；
- S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
Risk Statements
- R22 Harmful if swallowed 吞咽有害
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 275 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 71,70,1949
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 75 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 71,70,1949
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1250 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 71,70,1949
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