Flumethasone pivalate 特戊酸氟米松溶液,100ppm

CAS 2002-29-1 MFCD00079287

化学结构图

2002-29-1
SMILES: C[C@@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COC(=O)C(C)(C)C

化学属性

Mol. FormulaC27H36F2O6
Mol. Weight495

别名和识别编码

Chemical NameFlumethasone 21-Pivalate-d3
CAS Number2002-29-1
Synonym (6?,11?,16?)-21-(2,2-Dimethyl-1-oxopropoxy)-6,9-difluoro-11,17-dihydroxy-16-methyl-pregna-1,4-diene-3,20-dione 21-pivalate 6ALPHA,9-DIFLUORO-11BETA,17,21-TRIHYDROXY-16ALPHA-METHYLPREGNA-1,4-DIENE-3,20-DIONE 21-[2,2-DIMETHYLPROPIONATE] 6a,9a-Difluoro-16a-methyl-prednisolone-21-pivalate 6a,9a-difluoro-16a-methyl-prednisolone-21-pivalate 6α,9-Difluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-(2,2-dimethylpropionate) 6α,9-Difluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-(2,2-dimethylpropionate) Flumetasone 21-pivalate NSC 107680 6α,9-difluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-(2,2-dimethylpropionate) 6α,9α-Difluoro-11β,17α,21-trihydroxy-16α-methyl-1,4-pregnadiene-3,20-dione 21-pivalate 6α,9α-Difluoro-16α-methylprednisolone 21-pivalate Cerson FLUMETHASONE PIVA
MDL NumberMFCD00079287
EC Number217-901-1
PubChem Substance ID443980
Chemical Name Translation特戊酸氟米松溶液,100ppm
InChIInChI=1S/C27H36F2O6/c1-14-9-16-17-11-19(28)18-10-15(30)7-8-24(18,5)26(17,29)20(31)12-25(16,6)27(14,34)21(32)13-35-22(33)23(2,3)4/h7-8,10,14,16-17,19-20,31,34H,9,11-13H2,1-6H3/t14-,16+,17+,19+,20+,24+,25+,26+,27+/m1/s1
LabNetwork Molecule IDLN01303500
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分类

  • {SNA} Antibiotics, Antibiotics A to Z, Antibiotics A-F, Biochemicals and Reagents
  • Steroids
  • Pharmaceuticals
  • {SNA} Antibiotics A to Z, Antibiotics A-F, 抗生素, 生化试剂
  • {SNA} Antibiotics, Antibiotics A to Z, Antibiotics A-F
  • Intermediates & Fine Chemicals

产品应用

  • An anti-inflammatory anti-itching corticosteroid found in topical creams.

相关文献及参考

  • Fliri, A., et al.: J. Med. Chem., 52, 8038 (2009),
  • Hoeller, S., et al.: J. Pharm. Sci., 98, 2686 (2009),

安全信息

Hazard Codes Xn
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Risk Statements
  • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
WGK Germany3
GHS Symbol
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
  • P203
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P308+P313
  • P318
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H351 Suspected of causing cancer 怀疑致癌
RTECSTU3832010
Signal word Warning
Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,705,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,705,1982

其他信息

  • MOL 文件:2002-29-1.mol
  • Sigma Aldrich:2002-29-1(sigmaaldrich)

系列性分类

  1. Life Science 生命科学
  2. Antibiotics 抗生素
  3. Antibiotics A to Z - Antibiotics
  4. Antibiotics A-F - Antibiotics A to Z
  1. Life Science 生命科学
  2. Antibiotics 抗生素
  3. Antibiotics A to Z - Antibiotics
  4. Antibiotics A-F - Antibiotics A to Z

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