Terfenadine 特非那定

CAS 50679-08-8 MFCD00079622

化学结构图

50679-08-8
SMILES: CC(C)(C)C1C=CC(=CC=1)C(O)CCCN1CCC(CC1)C(O)(C1C=CC=CC=1)C1C=CC=CC=1

化学属性

Mol. FormulaC32H41NO2
Mol. Weight471.67
TSCANo
Melting Point145-152°

别名和识别编码

Chemical NameTerfenadine
CAS Number50679-08-8
Synonym Terfen α-[4-(1,1-Dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1-piperidinebutanol MDL 9918 Seldane Terfenadine Triludan Aldaban RMI 9918 Allerplus Terdin Nebralin alpha-(4-(1,1-Dimethylethyl)phenyl)-4-(hydroxydiphenylmethyl)-1-piperidinebutanol Teldane ?-[4-(1,1-Dmethylethyl)phenyl]-4-(hydroxydiphenylmethyl)- Teldanex
MDL NumberMFCD00079622
PubChem Substance ID24277779
EC Number256-710-8
Merck Number14,9163
Wiswesser Line NotationT6NTJ A3YQR DX1&1&1& DXQR&R
Beilstein Registry Number5857899
Chemical Name Translation特非那定
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

分类

  • Pharmaceuticals
  • {SNA} Application Index, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Cell Signaling Enzymes, Drug and Xenobiotic Metabolism, Fluorination Ready Pharma-Developed Compounds, Multi-Drug Resistance and Drug Metabolism, Sanofi Aventis, Substrates, Inducers, Inhibitors, T, Xenobiotics And Drug Metabolism Substrates, Xenobiotics and Drug Metabolism, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学, 酶、抑制剂和底物
  • {SNA} Application Index, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Cell Signaling Enzymes, Drug and Xenobiotic Metabolism, Fluorination Ready Pharma-Developed Compounds,

产品应用

  • Nonsedating-type histamine H1-receptor antagonist. Antihistaminic.

相关文献及参考

  • [2]. Nicolau-Galmés F, et al. Terfenadine induces apoptosis and autophagy in melanoma cells through ROS-dependent and -independent mechanisms. Apoptosis. 2011 Dec;16(12):1253-67.
  • [3]. An L, et al. Terfenadine combined with epirubicin impedes the chemo-resistant human non-small cell lung cancer both in vitro and in vivo through EMT and Notch reversal. Pharmacol Res. 2017 Oct;124:105-115.
  • Badwan, A.A., et al.: Anal. Profiles Drug Subs., 19, 627 (1990),
  • Carr, A.A., et al.: Arzneim. Forsch., 32, 1157 (1982),
  • Masheter, H.C., et al.: Clin. Rev. Allergy, 11, 5 (1993),
  • [1]. Kamiya K, et al. Molecular determinants of hERG channel block by terfenadine and cisapride. J Pharmacol Sci. 2008 Nov;108(3):301-307.
  • [1]. Kamiya K, et al. Molecular determinants of hERG channel block by terfenadine and cisapride. J Pharmacol Sci. 2008 Nov;108(3):301-307.
  • [2]. Nicolau-Galmés F, et al. Terfenadine induces apoptosis and autophagy in melanoma cell

安全信息

WGK Germany2
RTECSTM4969000
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 190 mg/kg/23W-I
TOXIC EFFECTS :
   Behavioral - muscle weakness
   Liver -

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - child
DOSE/DURATION           : 3 mg/kg
TOXIC EFFECTS :
   Skin and Appendages - dermatitis, other (after systemic exposure)
   Immunological Including Allergic - other immediate (humoral): urticaria,
   allergic rhinitis, serum sickness
REFERENCE :
   BMJOAE British Medical Journal.  (British Medical Assoc., BMA House,
   Tavistock Sq., London WC1H 9JR, UK)  V.1-    1857- Volume(issue)/page/year:
   293,536,1986

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 246 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 21,319,1990

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 154 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 21,319,1

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATIO

TYPE OF TEST            : TDL

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 17100 mg/kg
SEX/DURATION            : female 14 day(s) pre-mating  - 21 day(s) post-birth
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
   alive at weaning per # alive at day 4)
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 32,1179,1982

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 8550 mg/kg
SEX/DURATION            : female 14 day(s) pre-mating  - 21 day(s) post-birth
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 32,1179,1982

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 8400 mg/kg
SEX/DURATION            : female 14 day(s) pre-mating
                          female 1-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 32,1179,1982

TYPE OF TEST

系列性分类


相关产品推荐