E-64 N-(反式-环氧丁二酰基)-L-亮氨酸-4-胍基丁基酰胺

CAS 66701-25-5 MFCD00080261

化学结构图

66701-25-5
SMILES: CC(C)C[C@H](NC(=O)[C@@H]1O[C@H]1C(=O)O)C(=O)NCCCCNC(=N)N

化学属性

Mol. FormulaC15H27N5O5
Mol. Weight357

别名和识别编码

Chemical NameE-64
Synonym E 64 E 64 (proteinase inhibitor) E-64 L-trans-epoxysuccinyl-leucylamido(4-guanidino)butane N-(N-(L-3-trans-carboxyoxirane-2-carbonyl)-L-leucyl)agmatine Proteinase inhibitor E 64 Thiol protease inhibitor trans-Epoxysuccinyl-L-leucylamido(4-guanidino)butane L-trans-3-Carboxyoxiran-2-carbonyl-L-leucylagmatine N-(trans-Epoxysuccinyl)-L-leucine 4-guanidinobutylamide
MDL NumberMFCD00080261
PubChem Substance ID123985
Beilstein Registry Number1405664
CAS Number66701-25-5
Chemical Name TranslationN-(反式-环氧丁二酰基)-L-亮氨酸-4-胍基丁基酰胺
LabNetwork Molecule IDLN02127073
InChIInChI=1S/C15H27N5O5/c1-8(2)7-9(20-13(22)10-11(25-10)14(23)24)12(21)18-5-3-4-6-19-15(16)17/h8-11H,3-7H2,1-2H3,(H,18,21)(H,20,22)(H,23,24)(H4,16,17,19)/t9-,10-,11-/m0/s1
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分类

  • {SNA} A to C, Application Index, Bromelain, Cathepsin B, Cathepsin B Inhibitors, Cathepsin/Granzyme Inhibitors & Substrates, Cell Signaling Enzymes, Core Bioreagents, D to K, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Ficin, Individual Protease Inhibitors, Inhibitors, Life Science Reagents for Protein Expression and Purification, Lysosomal Proteases, P to Q, Papain, Peptides and Proteins, Peptides for Cell Biology, Protease Inhibitor Specificity Index, Protease Inhibitors, Proteasome, Calpain and Lysosomal Proteases, Research Essentials,

相关文献及参考

  • [2]. Wadhawan M, et al. Inhibition of cathepsin B by E-64 induces oxidative stress and apoptosis in filarial parasite. PLoS One. 2014 Mar 25;9(3):e93161.
  • [3]. Baldzizhar R, et al. Anti-serpin antibody-mediated regulation of proteases in autoimmune diabetes. J Biol Chem. 2013 Jan 18;288(3):1612-9.
  • [4]. Blass G, et al. Chronic cathepsin inhibition by E-64 in Dahl salt-sensitive rats. Physiol Rep. 2016 Sep;4(17). pii: e12950.
  • , Beynon, R.J. and Bond, J.S., ed. Proteolytic Enzymes: A Practical Approach New York, NY , (1989), 244
  • 1. Govrin, E., and Levine, A., Purification of active cysteine proteases by affinity chromatography with attached E-64 inhibitor Protein Expr. Purif. 15 , 247-250, (1999) 摘要
  • Barrett, A.J., et al. Biochem. J. 201 , 189, (1982) 摘要
  • Beil. 18 ,V,7,6
  • Hanada, K., et al. Agric. Biol. Chem. 42 , 523, (1978)
  • Li, Z., et al., Similarities In The Behavior And Molecular Deficits In The Frontal Cortex

安全信息

WGK Germany3
RTECSRR0390000 RR0390000 RR0390000 RR0390000
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
GHS Symbol 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 50 mg/kg
SEX/DURATION            : female 9 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Specific Developmental Abnormalities - eye/ear
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   KDIZAA Kagoshima Daigaku Igaku Zasshi.  Medical Journal of Kagoshima
   University.  (Kagoshima Daigaku Igakkai, 1208-1, Usuki

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 60 mg/kg
SEX/DURATION            : female 9-10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Specific Developmental Abnormalities - eye/ear
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   APDJBE Acta Paediatrica Japonica (Overseas Edition).  (Societas Pediatrica
   Japonica, 1-1-5-Koraku, Bunkyo-ku, Tokyo, 112, Japan)  V.1-  1958-
   Volume(issue)/page/year: 32,495,1990

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 60 mg/kg
SEX/DURATION            : female 9-10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - cardiovascular
   (circulatory) system
   Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
   APDJBE Acta Paediatrica Japonica (Overseas Edition).  (Societas Pediatrica
   Japonica, 1-1-5-Koraku, Bunkyo-ku, Tokyo, 112, Japan)  V.1-  1958-
   Volume(issue)/page/year: 32,495,1990

Hazard statements
  • H371 May cause damage to organs 可能导致器官损伤
Precautionary statements
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P309+P311
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. E - Bioactive Small Molecules
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. C - Alphabetic
  5. CA - CG - C
  1. Research Essentials 基础科研
  2. Core Bioreagents - Research Essentials
  3. Life Science Reagents for Protein Expression and Purification - Core Bioreagents
  4. Protease Inhibitors - Life Science Reagents for Protein Expression and Purification
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Enzyme - Enzyme Inhibitors
  6. A to C - Enzyme Inhibitors by Enzyme
  7. Bromelain - A to C
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Type - Enzyme Inhibitors
  6. Organic Covalent Modifiers - Enzyme Inhibitors by Type
  1. Medical Research Areas
  2. Metabolism
  3. Cathepsin  (组织蛋白酶)

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