Forskolin, 98% (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(乙酰氧基)-3-乙烯基十二烷基-6,10,10b-三羟基-3,4a,7,7,10a-五甲基-1H- 萘并[2,1-b]吡喃-1-酮

CAS 66575-29-9 MFCD00082317

化学结构图

66575-29-9
SMILES: CC1(C)CC[C@H](O)[C@@]2(C)[C@H]1[C@H](O)[C@H](OC(C)=O)[C@@]1(C)O[C@](C)(CC(=O)[C@@]12O)C=C

化学属性

Mol. FormulaC22H34O7
Mol. Weight411
TSCANo
SolubilitySoluble in DMSO or ethanol.
Melting Point228

别名和识别编码

Chemical NameForskolin, 98%
CAS Number66575-29-9
Synonym (-)-Forskolin (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-Naphtho[2,1-b]pyran-1-one 7-beta-Acetoxy-8,13-epoxy-1-alpha,6-beta,9-alpha-trihydroxylabd-14-en-11-one 7β-Acetoxy-8,13-epoxy-1α,6β,9α-trihydroxylabd-14-en-11-one Coleonol Colforsin Coleonol Colforsin ForsLean Forskolin HL 362 L 7
PubChem Substance ID253661985
EC Number266-410-9
Beilstein Registry Number1692716
MDL NumberMFCD00082317
Merck Number2476
Chemical Name Translation(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(乙酰氧基)-3-乙烯基十二烷基-6,10,10b-三羟基-3,4a,7,7,10a-五甲基-1H- 萘并[2,1-b]吡喃-1-酮
Reaxys-RN4300863
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分类

  • Adenylyl Cyclase Activators, Antitumor Agents, Bioactive Small Molecules, Biochemicals and Reagents, Cancer Research, Cell Biology, Cell Signaling and Neuroscience, Cyclic Nucleotide Metabolism, Enzyme Activators, F, G Proteins and Cyclic Nucleotides, Isoprenoids, Lipids,
  • {SNA} Adenylyl Cyclase Activators, Antitumor Agents, Bioactive Small Molecule Alphabetical Index, Cyclic Nucleotide Metabolism, Enzyme Activators,
  • {SNA} Biochemicals, Isoprenoids, Prenols, 分子生物学, 分子生物学试剂, 生化试剂, 脂类
  • {SNA} Alphabetical Index of Phytochemical Standards,
  • {SNA} Adenylyl Cyclase Activat

产品应用

  • Diterpene isolated from Coleus forskohlii, possessing vasodilating and cardiostimulatory properties.

相关文献及参考

  • [2]. Matsumiya W, et al. Forskolin modifies retinal vascular development in Mrp4-knockout mice. Invest Ophthalmol Vis Sci. 2012 Dec 7;53(13):8029-35.
  • [3]. Mayati A, et al. Functional polarization of human hepatoma HepaRG cells in response to forskolin. Sci Rep. 2018 Oct 31;8(1):16115.
  • [4]. Awad JA, et al. Interactions of forskolin and adenylate cyclase. Effects on substrate kinetics and protection against inactivation by heat and N-ethylmaleimide. J Biol Chem. 1983 Mar 10;258(5):2960-5.
  • [5]. Seamon KB, et al. Structure-activity relationships for activation of adenylate cyclase by the diterpene forskolin and its derivatives. J Med Chem. 1983 Mar;26(3):436-9.
  • [6]. Ríos-Silva M, et al. Effect of chronic administration of forskolin on glycemia and oxidative stress in rats with and without experimental diabetes. Int J Med Sci. 2014 Mar 11;11(5):448-52.
  • [7]. Rodriguez G, et al. Forskolin-inducible cAMP pathway negatively regulates T-c

安全信息

GHS Symbol
WGK Germany3
Hazard Codes Xn
Hazard statements
  • H303 May be harmfully swallowed 吞食可能有害
  • H312 Harmful in contact with skin 皮肤接触有害
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
RTECSQL6150000
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
Signal word Warning
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
Risk Statements
  • R21 Harmful in contact with skin 与皮肤接触有害
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 68 mg/kg
TOXIC EFFECTS :
   Behavioral - changes in motor activity (specific assay)
REFERENCE :
   JOETD7 Journal of Ethnopharmacology.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1979-  Volume(issue)/page/year:
   3,1,1981

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2550 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MRREDD Medicinal Research Reviews.  (John Wiley & Sons, Inc., 605 Third
   Ave., New York, NY 10158) V.1-    1981-  Volume(issue)/page/year: 3,201,1983

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MRREDD Medicinal Research Reviews.  (John Wiley & Sons, Inc., 605 Third
   Ave., New York, NY 10158) V.1-    1981-  Volume(issue)/page/year: 3,201,1983

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 92 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 31,1872,1988

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. F - Bioactive Small Molecules
  1. Life Science 生命科学
  2. Molecular Biology 分子生物学
  3. Molecular Biology Reagents - Molecular Biology
  4. Biochemicals - Molecular Biology Reagents
  1. Life Science 生命科学
  2. Molecular Biology 分子生物学
  3. Molecular Biology Reagents - Molecular Biology
  4. Biochemicals - Molecular Biology Reagents
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. G Proteins and Cyclic Nucleotides - Cell Signaling and Neuroscience
  5. Cyclic Nucleotide Metabolism - G Proteins and Cyclic Nucleotides
  6. Adenylyl Cyclase Activators - Cyclic Nucleotide Metabolism
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. G Proteins and Cyclic Nucleotides - Cell Signaling and Neuroscience
  5. Cyclic Nucleotide Metabolism - G Proteins and Cyclic Nucleotides
  6. Adenylyl Cyclase Activators - Cyclic Nucleotide Metabolism
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Biochemicals Found in Plants
  4. Enzyme cofactor
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Molecular Biology
  4. Molecular Biology Reagents
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. G Proteins and Cyclic Nucleotides
  5. Cyclic Nucleotide Metabolism
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Nutrition Research
  4. Biochemicals Found in Plants
  5. Enzyme cofactor
  1. Medical Research Areas
  2. GPCR & G Protein
  3. Adenylate Cyclase  (腺苷酸环化酶)
  1. Medical Research Areas
  2. Metabolism
  3. FXR  (法尼酯X受体)

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