(S)-4-(2-(N-Methylisoquinoline-5-Sulfonamido)-3-Oxo-3-(4-Phenylpiperazin-1-Yl)Propyl)Phenyl Isoquinoline-5-Sulfonate (S)-4-(2-(N-甲基异喹啉-5-磺胺)-3-氧代-3-(4-苯基哌嗪-1-基)丙基)苯基异喹啉-5-磺酸盐

CAS 127191-97-3 MFCD00083180

化学结构图

127191-97-3
SMILES: CN([C@@H](CC1C=CC(=CC=1)OS(=O)(=O)C1C=CC=C2C=NC=CC=12)C(=O)N1CCN(CC1)C1C=CC=CC=1)S(=O)(=O)C1=CC=CC2C=NC=CC1=2

化学属性

Mol. FormulaC38H35N5O6S2
Mol. Weight721.84
TSCANo
Melting Point65-67°

别名和识别编码

Chemical Name(S)-4-(2-(N-Methylisoquinoline-5-Sulfonamido)-3-Oxo-3-(4-Phenylpiperazin-1-Yl)Propyl)Phenyl Isoquinoline-5-Sulfonate
CAS Number127191-97-3
Synonym (S)-5-Isoquinolinesulfonic acid 4-[2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl ester 1-[N,O-bis(5-Isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine 1-(N,O-Bis-[5-isoquinolinesulfonyl]-N-methyl-L-tyrosyl)-4-phenylpiperazine, (S)-5-Isoquinolinesulfonic Acid 4-(2-[(5-Isoquinolinylsulfonyl)methylamino]- 3-oxo-3-[4-phenyl-1-piperazinyl]propyl)phenyl E KN-62
MDL NumberMFCD00083180
PubChem Substance ID24895961
Chemical Name Translation(S)-4-(2-(N-甲基异喹啉-5-磺胺)-3-氧代-3-(4-苯基哌嗪-1-基)丙基)苯基异喹啉-5-磺酸盐
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分类

  • {SNA} A to C, Bioactive Small Molecule Alphabetical Index, Calcium/Calmodulin-Dependent Protein Kinase (CaMK), Calmodulin dependent Protein Kinase II, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, K, Kinase/Phosphatase Biology, P to Q, Peptides and Proteins, Peptides for Cell Biology, Protein Kinase II, Calmodulin dependent, Protein Kinase Inhibitors, Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学, 酶、抑制剂和底物
  • {SNA} A to C, Bioactive Small Molecules, Biochemicals and Reagents, Calcium/Calmodulin-Dependent Protein Kinase (CaMK),

产品应用

  • A specific inhibitor of Ca2+/Calmodulin-dependent protein kinase II.

相关文献及参考

  • Tokumitsu, H., et al.: Journal of Biological Chem., 205, 8, 4315 (1990),

安全信息

WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

系列性分类


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