4-Formylaminoantipyrine 4-甲酰氨基安替比林

CAS 1672-58-8 MFCD00085457

化学结构图

1672-58-8
SMILES: Cc1c(NC=O)c(=O)n(-c2ccccc2)n1C

化学属性

Mol. FormulaC12H13N3O2
Mol. Weight231
Melting Point189-192

别名和识别编码

Chemical Name4-Formylaminoantipyrine
CAS Number1672-58-8
Synonym 4-(Formylamino)antipyrine 4-Formamidoantipyrine 4-formylaminoantipyrine 4-甲酰氨基安替吡啉 N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)formamide N-(1,5-二甲基-3-氧代-2-苯基-2,3-二氢-1H-吡唑-4-基)甲酰胺 N-(2,3-Dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)formamide N-Antipyrinylformamide NSC 60565
MDL NumberMFCD00085457
Beilstein Registry Number217665
EC Number216-808-3
Alfabeta NameDIMETHYLOXOPHENYLDIHYDROPYRAZOLYLFORMAMIDE H15322314()-----------,,
Chemical Name Translation4-甲酰氨基安替比林
LabNetwork Molecule IDLN00178869
PubChem Substance ID72666
InChIInChI=1S/C12H13N3O2/c1-9-11(13-8-16)12(17)15(14(9)2)10-6-4-3-5-7-10/h3-8H,1-2H3,(H,13,16)
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分类

  • {SNA} APIs & Metabolites, APIs (Active Pharmaceutica
  • {SNA} APIs & Metabolites, APIs (Active Pharmaceutical Ingredients) & Metabolites, All alphabetically sorted, Analytical Standards, Analytical/Chromatography, Chromatography, Metamizol & Metabolites, Pharmaceutical Standards
  • {SNA} APIs & Metabolites, APIs (Active Pharmaceutical Ingredients) & Metabolites, Additional Standards, Analytical Standards, Chromatography, Metamizol Metabolites, Pharmaceutical Standards, 分析/色谱
  • {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, EP Standards, EP Standards L - M, Pharmaceutical Standards, Pharmacopeia Standards

产品应用

  • A metabolite of Dipyrone, a nonsteroidal anti-inflammatory drug.

相关文献及参考

  • [2]. A Noda, et al.Formation of 4-formylaminoantipyrine as a new metabolite of aminopyrine. II. Enzymatic demethylation and oxidation of aminopyrine and 4-monomethylaminoantipyrine. Chem Pharm Bull (Tokyo).1976 Dec;24(12):3229-31.
  • [3]. David do C Malvar, et al. Dipyrone metabolite 4-MAA induces hypothermia and inhibits PGE2 -dependent and -independent fever while 4-AA only blocks PGE2 -dependent fever. Br J Pharmacol. 2014 Aug;171(15):3666-79.
  • Kujubu, D., et al.: J. Biol. Chem., 266, 12866
  • [1]. M Levy, et al. Impairment of the metabolism of dipyrone in asymptomatic carriers of the hepatitis B virus. Clin Pharmacol Ther
  • [1]. M Levy, et al. Impairment of the metabolism of dipyrone in asymptomatic carriers of the hepatitis B virus. Clin Pharmacol Ther
  • [2]. A Noda, et al.Formation of 4-formylaminoantipyrine as a new metabolite of aminopyrine. II. Enzymatic demethylation and oxidation of aminopyrine and 4-monomethylaminoantipyrine. Chem Phar

安全信息

GHS Symbol
Precautionary statements
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P301+P312
  • P301+P312+P330
  • P301+P317
  • P304+P340
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P316
  • P320 Specific treatment is urgent (see … on this label). 紧急具体治疗（见本标签上的）。
  • P330 Rinse mouth. 漱口
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H330 Fatal if inhaled 吸入致命
WGK Germany3
Signal word Danger Warning
Warnings IRRITANT
Hazard Codes Xn
Risk Statements
  • R20/22 Harmful by inhalation and if swallowed 吸入和不慎吞咽有害

系列性分类

  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Pharmaceutical Standards - Chromatography
  5. API Metabolites - Pharmaceutical Standards
  6. All alphabetical sorted - Active Pharmaceutical Ingredients (API) and its Metabolites
  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)

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