2-Amino-1,9-dihydro-6H-purine-6-thione 6-硫鸟嘌呤
CAS 154-42-7 MFCD00127785
化学结构图
SMILES: Nc1nc2[nH]cnc2c(=S)[nH]1
化学属性
| Mol. Formula | C5H5N5S |
|---|---|
| Mol. Weight | 167.19 |
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
| Melting Point | ≥300 °C |
| Boiling Point | 555.4 °C at 760 mmHg |
别名和识别编码
| Chemical Name | 2-Amino-1,9-dihydro-6H-purine-6-thione |
|---|---|
| Chemical Name Translation | 6-硫鸟嘌呤 |
| PubChem Substance ID | 2723601 |
| InChI | InChI=1S/C5H5N5S/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) |
| Formula | C5H5N5S |
| Synonym | 6-Thioguanine {LY} 6-Thioguanine {} {LY} 6-Thioguanine {} {} {LY} 6-Thioguanine {} {} {} {LY} 6-Thioguanine {} {} {} {} {LY} 6-Thioguanine {} {} {} {} {} {LY} 6-Thioguanine {} {} {} {} {} {} {LY} 6-Thioguanine {} {} {} {} {} {} {} {LY} 6-Thioguanine {} {} {} {} {} {} {} {} {LY} 6-Thioguanine {} {} {} {} {} {} {} {} {} {LY} 6-Thioguanine {} {} {} {} {} {} {} {} {} {} {LY} 6-Thioguanine {} {} {} {} {} {} {} {} {} {} {} {LY} 6-Thioguanine {} {} {} {} {} {} {} {} {} {} {} {} {LY} 6-Thioguanine {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 6-Thioguanine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 6-Thioguanine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 6-Thioguanine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 6-Thioguanine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 6-Thioguanine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 6- |
| IUPAC Name | 2-amino-1H-purine-6(7H)-thione |
| InChIKey | WYWHKKSPHMUBEB-UHFFFAOYSA-N |
| Canonical SMILES | SC1=NC(N)=NC2=C1N=CN2 |
| MDL Number | MFCD02730136 |
| CAS Number | 154-42-7 |
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产品应用
- Tioguanine (INN, BAN), or thioguanine (AAN, USAN), commonly referred to as 6-thioguanine (6-TG) is a medication used to treat a number of types of leukemia. It has been used less frequently in recent years because of safety concerns. However, it is becoming more widely used for treating ulcerative colitis and some autoimmune diseases.
相关文献及参考
- [2]. Wang H, et al. 6-Thioguanine perturbs cytosine methylation at the CpG dinucleotide site by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo. Biochemistry. 2009 Mar 17;48(10):2290-9.
- [3]. LaDuke KE, et al. Effects of azathioprine, 6-mercaptopurine, and 6-thioguanine on canine primary hepatocytes. Am J Vet Res. 2015 Jul;76(7):649-55.
- [1]. Chuang SJ, et al. 6-Thioguanine is a noncompetitive and slow binding inhibitor of human deubiquitinating protease USP2. Sci Rep. 2018 Feb 15;8(1):3102.
- [1]. Chuang SJ, et al. 6-Thioguanine is a noncompetitive and slow binding inhibitor of human deubiquitinating protease USP2. Sci Rep. 2018 Feb 15;8(1):3102.
- [2]. Wang H, et al. 6-Thioguanine perturbs cytosine methylation at the CpG dinucleotide site by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo. Biochemistry. 2009 Mar 17;48(10):2290-9.
- [3]. LaDuke KE, et al. Effects of azathioprine, 6-m
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