(2S,3S)-3-(((S)-1-(Isopentylamino)-4-Methyl-1-Oxopentan-2-Yl)Carbamoyl)Oxirane-2-Carboxylic Acid (2S,3S)-3-(((S)-1-(异戊基氨基)-4-甲基-1-氧代戊烷-2-基)氨甲酰)环氧乙烷-2-羧酸

CAS 76684-89-4 MFCD00132882

化学结构图

76684-89-4
SMILES: CC(C)C[C@H](NC(=O)[C@H]1O[C@@H]1C(O)=O)C(=O)NCCC(C)C

化学属性

Mol. FormulaC15H26N2O5
Mol. Weight314.38

别名和识别编码

Chemical Name(2S,3S)-3-(((S)-1-(Isopentylamino)-4-Methyl-1-Oxopentan-2-Yl)Carbamoyl)Oxirane-2-Carboxylic Acid
Synonym (+)-(2S,3S)-3-((S)-3-Methyl-1-(3-methylbutylcarbamoyl)butylcarbamoyl)-2-oxiranecarboxylic acid (2S,3S)-trans-Epoxysuccinyl-L-leucylamido-3-methylbutane E 64C E-64c EP 475 EP 475 (Enzyme inhibitor)
MDL NumberMFCD00132882
PubChem Substance ID24894369
CAS Number76684-89-4
Beilstein Registry Number6688621
Chemical Name Translation(2S,3S)-3-(((S)-1-(异戊基氨基)-4-甲基-1-氧代戊烷-2-基)氨甲酰)环氧乙烷-2-羧酸
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分类

  • {SNA} A to C, Apoptosis Enzymes, Application Index, Bioactive Small Molecules, Biochemicals and Reagents,
  • {SNA} A to C, Apoptosis Enzymes, Application Index, Calpain, Calpain II, Calpain II Inhibitors, Calpain Inhibitors, Cell Signaling Enzymes, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, General Inhibitors, Peptides and Proteins, Peptides for Cell Biology, Protease Inhibitor Specificity Index, Protease Inhibitors, Proteasome, Calpain and Lysosomal Proteases, 生化试剂, 细胞信号转导和神经科学, 细胞生物学, 酶、抑制剂和底物

相关文献及参考

  • [2]. Toda G, et al. Calcium-activated neutral protease inhibitor (E-64c) and reperfusion for experimental myocardial infarction. Jpn Heart J. 1989 May;30(3):375-86.
  • [3]. Radzey H, et al. E-64c-hydrazide: a lead structure for the development of irreversible cathepsin C inhibitors. ChemMedChem. 2013 Aug;8(8):1314-21.
  • [4]. Ji Yeun Kim, et al. Safe, High-Throughput Screening of Natural Compounds of MERS-CoV Entry Inhibitors Using a Pseudovirus Expressing MERS-CoV Spike Protein. Int J Antimicrob Agents. 2018 Nov;52(5):730-732.
  • [1]. Khan MS, et al. Design, synthesis, evaluation and thermodynamics of 1-substituted pyridylimidazo[1,5-a]pyridine derivatives as cysteine protease inhibitors. PLoS One. 2013 Aug 5;8(8):e69982.
  • [1]. Khan MS, et al. Design, synthesis, evaluation and thermodynamics of 1-substituted pyridylimidazo[1,5-a]pyridine derivatives as cysteine protease inhibitors. PLoS One. 2013 Aug 5;8(8):e69982.
  • [2]. Toda G, et al. Calcium

安全信息

WGK Germany3
RTECSRR0404200
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2140 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 17,736,1986

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 17,736,1986

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2400 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2400 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, T

系列性分类


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