2-Fluoroadenine-9-β-D-Arabinofuranoside 氟达拉宾
CAS 21679-14-1 MFCD00132942
化学结构图
SMILES: NC1=NC(F)=NC2=C1N=CN2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O |&1:11,13,16,18|
化学属性
| Mol. Formula | C10H12FN5O4 |
|---|---|
| Mol. Weight | 285 |
| TSCA | No |
别名和识别编码
| Chemical Name | 2-Fluoroadenine-9-β-D-Arabinofuranoside |
|---|---|
| CAS Number | 21679-14-1 |
| Alfabeta Name | AMINOFLUOROPURINYLHYDROXYMETHYLTETRAHYDROFURANDIOL RSSRH234526299534((()))-------------,,,, |
| MDL Number | MFCD00132942 |
| Synonym | 2-Fluoro-9-?-D-arabinofuranosyladenine 2-Fluoroadenine Arabinoside 2-Fluoroadenine-9-β-D-arabinofuranoside 9-?-D-Arabinofuranosyl-2-fluoro-9H-purin-6-amine 9-bata-D-Arabinofuranosyl-2-fluoroadenine; 2-Fluoroadenine-9-bata-D-arabinofuranoside 9-beta-D-Arabinofuranosyl-2-fluoroadenine 9-β-D-Arabinofuranosyl-2-fluoroadenine F-ara-A Fludarabine des-phosphate F-Ara-A Fludarabine NSC 118218 NSC 118218H |
| Beilstein Registry Number | 1225932 |
| EC Number | 244-525-5 |
| PubChem Substance ID | 24894830 |
| Merck Number | 14,4126 |
| Chemical Name Translation | 氟达拉宾 |
| Wiswesser Line Notation | T56 BN DN FN HNJ GF IZ D- BT5OTJ CQ DQ E1Q |
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分类
- Pharmaceuticals
- {SNA} DNA Synthesis Inhibitors, 抗肿瘤药物, 癌症研究, 细胞生物学
- Intermediates & Fine Chemicals,
- {SNA} Antitumor Agents, Bioactive Small Molecules, Cancer Research, Cell Biology, DNA Synthesis Inhibitors, F
产品应用
- Used as an antineoplastic.
相关文献及参考
- Brockman, R.W., et al.: Biochem. Pharmacol., 26, 2193 (1977),
- Brockman, R.W., et al.: Cancer Res., 40, 3610 (1980),
- Chun, H.G., et al.: Cancer Treat. Rep., 70, 1225 (1986),
安全信息
GHS Symbol
- H302 Harmful if swallowed 吞食有害
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- R22 Harmful if swallowed 吞咽有害
- R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R39 Danger of very serious irreversible effects 有非常严重的不可挽回的作用的危险
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 375 mg/kg TOXIC EFFECTS : Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 42,2587,1982
TYPE OF TEST : Mutation in mammalian somatic cells TEST SYSTEM : Rodent - hamster Ovary DOSE/DURATION : 100 umol/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 210,291,1989
TYPE OF TEST : DNA inhibition ROUTE OF EXPOSURE : Intraperitoneal TEST SYSTEM : Rodent - mouse DOSE/DURATION : 41 mg/kg REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 42,2587,1982
TYPE OF TEST : DNA inhibition TEST SYSTEM : Human Lymphocyte DOSE/DURATION : 1500 nmol/L REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 40,1405,1980
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
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