7-((1H-imidazol-5-yl)methyl)-16-((1H-indol-3-yl)methyl)-26-amino-22-(2-((1-amino-3-methyl-1-oxobutan-2-yl)carbamoyl)pyrrolidine-1-carbonyl)-10-benzyl-13-(3-guanidinopropyl)-4-(8-(4-hydroxybenzyl)-5,11-bis(hydroxymethyl)-2-(2-(methylthio)ethyl)-4,7,10,13-t (1H-咪唑-5-基)甲基)-16-((1H-吲哚-3-基)甲基)-26-氨基-22-(2-(-((1-氨基-3-氨基-3-甲基-3-甲基-1-氧代丁基-2-基)氨基甲酰基)吡咯烷基-1-羰基)-10-苄基-13-(3-胍基丙基-13-(3-胍基丙基)-4-(8-(4-(4-羟基苄基)-5,11-双(2-(甲基硫代)乙基)-4,7,7,10,10,10,13-四氧---3,6,6,9,12-四氮杂十四烷基氨基甲酰氨基-5,8,8,11,11,11,11,11,11,11,11,11-氨基-1-(1-氨基-

CAS 581-05-5 MFCD00133062

化学结构图

581-05-5
SMILES: CSCCC(NC(=O)C(CO)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CO)NC(C)=O)C(=O)NC(CCC(=O)O)C(=O)NC(Cc1c[nH]cn1)C(=O)NC(Cc1ccccc1)C(=O)NC(CCCNC(=N)N)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NCC(=O)NC(CCCCN)C(=O)N1CCCC1C(=O)NC(C(N)=O)C(C)C

化学属性

Mol. FormulaC77H109N21O19S
Mol. Weight1664.88
Density0.99999

别名和识别编码

Chemical Name7-((1H-imidazol-5-yl)methyl)-16-((1H-indol-3-yl)methyl)-26-amino-22-(2-((1-amino-3-methyl-1-oxobutan-2-yl)carbamoyl)pyrrolidine-1-carbonyl)-10-benzyl-13-(3-guanidinopropyl)-4-(8-(4-hydroxybenzyl)-5,11-bis(hydroxymethyl)-2-(2-(methylthio)ethyl)-4,7,10,13-t
Synonym α-MSH;α-促黑激素 α-MSH α-Melanotropin α-Melanocyte stimulating hormone α-MSH α-Melanotropin 促黑激素
MDL NumberMFCD00133062
PubChem Substance ID16133793
Beilstein Registry Number741840
CAS Number581-05-5
Chemical Name Translation(1H-咪唑-5-基)甲基)-16-((1H-吲哚-3-基)甲基)-26-氨基-22-(2-(-((1-氨基-3-氨基-3-甲基-3-甲基-1-氧代丁基-2-基)氨基甲酰基)吡咯烷基-1-羰基)-10-苄基-13-(3-胍基丙基-13-(3-胍基丙基)-4-(8-(4-(4-羟基苄基)-5,11-双(2-(甲基硫代)乙基)-4,7,7,10,10,10,13-四氧---3,6,6,9,12-四氮杂十四烷基氨基甲酰氨基-5,8,8,11,11,11,11,11,11,11,11,11-氨基-1-(1-氨基-
InChIInChI=1S/C77H109N21O19S/c1-42(2)64(65(79)106)97-75(116)61-20-13-30-98(61)76(117)54(18-10-11-28-78)88-62(103)38-85-66(107)57(34-46-36-84-50-17-9-8-16-49(46)50)94-67(108)51(19-12-29-83-77(80)81)89-70(111)55(32-44-14-6-5-7-15-44)92-72(113)58(35-47-37-82-41-86-47)95-68(109)52(25-26-63(104)105)90-69(110)53(27-31-118-4)91-74(115)60(40-100)96-71(112)56(33-45-21-23-48(102)24-22-45)93-73(114)59(39-99)87-43(3)101/h5-9,14-17,21-24,36-37,41-42,51-61,64,84,99-100,102H,10-13,18-20,25-35,38-40,78H2,1-4H3,(H2,79,106)(H,82,86)(H,85,107)(H,87,101)(H,88,103)(H,89,111)(H,90,110)(H,91,115)(H,92,113)(H,93,114)(H,94,108)(H,95,109)(H,96,112)(H,97,116)(H,104,105)(H4,80,81,83)/t51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,64-/m0/s1
LabNetwork Molecule IDLN01806056
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分类

  • α-Melanocyte Stimulating Hormone (α-MSH), Cell Biology, Cell Signaling and Neuroscience, Cytokines Growth Factors and Hormones (Obesity), Cytokines, Growth Factors and Hormones, Hormones, Immunomodulators, Ion Channel Modulating Peptides, Lipid Metabolism (Obesity), Melanocyte Stimulating Hormone (MSH), Melanocyte Stimulating Hormones (MSH), Obesity Research, Peptides and Proteins, Peptides for Cell Biology, Pituitary Hormones
  • {SNA} α-Melanocyte Stimulating Hormone (α-MSH), Cell Biology, Cell Signaling and Neuroscience, Cytokines Growth Factors and Hormones (Obesity), Cytokines, Growth Factors and Hormones, Hormones, Immunomodulators, Ion Channel

相关文献及参考

  • [2]. M S Kim, et al. Hypothalamic localization of the feeding effect of agouti-related peptide and alpha-melanocyte-stimulating hormone. Diabetes. 2000 Feb;49(2):177-82.
  • [3]. Lipton JM, et al. Mechanisms of antiinflammatory action of alpha-MSH peptides. In vivo and in vitro evidence. Ann N Y Acad Sci. 1999;885:173-182.
  • Schulz, C., et al., Endogenous ACTH, Not Only Alpha-melanocyte-stimulating Hormone, Reduces Food Intake Mediated By Hypothalamic Mechanisms Am. J. Physiol. Cell Physiol. 298 , E237-E244, (2010) 摘要
  • [1]. Madhuri Singh, et al. C-terminal amino acids of alpha-melanocyte-stimulating hormone are requisite for its antibacterial activity against Staphylococcus aureus. Antimicrob Agents Chemother. 2011 May;55(5):1920-9.
  • [1]. Madhuri Singh, et al. C-terminal amino acids of alpha-melanocyte-stimulating hormone are requisite for its antibacterial activity against Staphylococcus aureus. Antimicrob Agents Chemother. 2011 May;55(5):1920-9.

安全信息

WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘；
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
Storage condition 储藏温度-20°C

其他信息

  • Ac-Ser-Tyr-Ser-Met-Glu-Hi?s-Phe-Arg-Trp-Gly-Lys-Pro?-Val-NH2
  • 氨基酸序列：

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Cytokines, Growth Factors and Hormones - Cell Signaling and Neuroscience
  5. Hormones - Cytokines, Growth Factors and Hormones
  6. Pituitary Hormones - Hormones
  7. Melanocyte Stimulating Hormone (MSH) - Pituitary Hormones
  1. Ion Channel Modulating Peptides - Peptides for Cell Biology
  2. Immunomodulators - Ion Channel Modulating Peptides
  1. Medical Research Areas
  2. GPCR & G Protein
  3. Melanocortin Receptor  (黑皮质素受体)

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