Alternariol 交链孢酚

CAS 641-38-3 MFCD00133068

化学结构图

641-38-3
SMILES:

化学属性

Mol. FormulaC14 H10 O5
Mol. Weight258.23
SolubilitySoluble in DMSO (~30 mg/ml), ethanol (~0.5 mg/ml), water (partly), acetone (2.20-2.80 mg/ml, clear, faint yellow to yellow), and DMF (~30 mg/ml).
Stability对光敏感
Melting Point>300C (dec.)
Boiling Point
Flash Point-

别名和识别编码

Chemical NameAlternariol
CAS Number641-38-3
Synonym 3,7,9-Trihydroxy-1-methyl-6H-dibenzo[b,d]pyran-6-one 3,7,9-三羟基-1-甲基-6H-二苯并[b,d]吡喃-6-酮 Alternariol {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
MDL Number-
PubChem Substance ID24890529
Beilstein Registry Number244839
Chemical Name Translation交链孢酚
Wiswesser Line NotationT B666 HOVJ C1 EQ KQ MQ
LabNetwork Molecule IDLN01265415
Canonical SMILES-
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

分类

  • Mutagenesis Research Chemicals
  • {SNA} A-AM, Bioactive Small Molecule Alphabetical Index, Mold, Toxins and Venoms, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • Inhibitors
  • {SNA} All alphabetically sorted, Analytical Standards, Biotoxins, Chromatography, Dried Down RMs,

产品应用

  • A mycotoxin with anti-proliferative activity

相关文献及参考

  • Asam, S., et al.: J. Agric. Food Chem., 57, 5152 (2009),
  • Fehr, M., et al.: Mol. Nut. Food Res., 53, 441 (2009),
  • Tiemann, U., et al.: Toxicol. Lett., 186, 139 (2009),

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P301+P310
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P302+P350
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
Hazard statements
  • H330 Fatal if inhaled 吸入致命
  • H310 Fatal in contact with skin 皮肤接触致命
  • H300 Fatal if swallowed 吞食致命
RTECSHP8757000
Signal word
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Safety Statements
Hazard Codes T+
Risk Statements
  • R26/27/28 Very toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有剧毒
Packing GroupI
UN Number
Storage condition -20 -20°C -20°C, Hygroscopic -20℃ 储存温度-20°C 储存温度-20°C,充氩储存 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EVHPAZ EHP, Environmental Health Perspectives.  (U.S. Government Printing
   Office, Supt of Documents, Washington, DC 20402)  No.1-    1972-
   Volume(issue)/page/year: 4,87,1973

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 400 mg/kg
SEX/DURATION            : female 13-16 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - other developmental
   abnormalities
REFERENCE :
   EVHPAZ EHP, Environmental Health Perspectives.  (U.S. Government Printing
   Office, Supt of Documents, Washington, DC 20402)  No.1-    1972-
   Volume(issue)/page/year: 4,87,1973

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 400 mg/kg
SEX/DURATION            : female 9-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   EVHPAZ EHP, Environmental Health Perspectives.  (U.S. Government Printing
   Office, Supt of Documents, Washington, DC 20402)  No.1-    1972-
   Volume(issue)/page/year: 4,87,1973

其他信息

  • Alternariol, a mycotoxin, has been shown to inhibit the short action current across transepithelial sodium pumps. This compound has also demonstrated the ability to have acute cytotoxic effects on cells and cause a halt in cell proliferation. At high doses, alternariol has been reported to induce cell growth arrest in G2/M phase. Additional experiments suggest that alternariol interacts with DNA by intercalation and causes DNA damage. Alternariol is an inhibitor of AChE and BChE.

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Toxins and Venoms - Cell Signaling and Neuroscience
  5. Mold - Toxins and Venoms
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Life Sciences Standards - Chromatography
  5. Biotoxins - Life Sciences Standards
  6. Mycotoxins - Biotoxins
  7. Alphabetical sorted - Mycotoxins

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