HISTRELIN

CAS 76712-82-8 MFCD00133494

化学结构图

76712-82-8
SMILES: CC(C)C[C@H](NC(=O)[C@@H](CC1=CN(CC2C=CC=CC=2)C=N1)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CO)NC(=O)[C@H](CC1=CNC2C=CC=CC=21)NC(=O)[C@H](CC1=CNC=N1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)NCC

化学属性

Mol. FormulaC66H86N18O12
Mol. Weight1323.50

别名和识别编码

Chemical Name[des-Gly10, D-His(Bzl)6]-LH-RH ethylamide
Synonym Histrelin ((ImBl)-D-His(sub 6),Pro(sub 9)-NEt)LHRH ORF 17070
MDL NumberMFCD00133494
PubChem Substance ID24896325
CAS Number76712-82-8
Beilstein Registry Number4290557
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分类

  • Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, L, LH-RH, Neuropeptides, Peptides and Proteins, Peptides for Cell Biology, Releasing Factors
  • {SNA} LH-RH, Neuropeptides, Peptides and Proteins, Peptides for Cell Biology, Releasing Factors, 细胞信号转导和神经科学, 细胞生物学
  • {SNA} Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, L, LH-RH, Neuropeptides, Peptides and Proteins, Peptides for Cell Biology, Releasing Factors

相关文献及参考

  • Lecomte, P., et al., The antiandrogenic action of gonadotropin-releasing hormone and its agonists on the mouse kidney. Endocrinology 110 , 1-6, (1982) 摘要
  • McCreery, B.R., et al., Actions of agonistic and antagonistic analogs of gonadotropin releasing hormone (Gn-RH) in the bullfrog Rana catesbeiana . Gen. Comp. Endocrinol. 46 , 511-520, (1982) 摘要
  • Sundaram, K., et al., Inhibition of the action of sex steroids by gonadotropin-releasing hormone (GnRH) agonists: a new biological effect. Life Sci. 28 , 83-88, (1981) 摘要
  • Merck 14 ,4722

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P308+P313
  • P201 Obtain special instructions before use. 使用前获取专门指示。
Signal word Danger
Hazard statements
  • H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
Hazard Codes T
RTECSOK6370800
Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 2333 ug/kg
SEX/DURATION            : male 4 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
REFERENCE :
   JOAND3 Journal of Andrology.  (Lippincott/Harper, Journal Fulfillment Dept.,
   2350 Virginia Ave., Hagerstown, MD 21740)  V.1-    1980-
   Volume(issue)/page/year: 7,140,1986

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 46 ug/kg
SEX/DURATION            : male 2 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
   Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
   accessory glands
   Reproductive - Paternal Effects - other effects on male
REFERENCE :
   JOAND3 Journal of Andrology.  (Lippincott/Harper, Journal Fulfillment Dept.,
   2350 Virginia Ave., Hagerstown, MD 21740)  V.1-    1980-
   Volume(issue)/page/year: 7,140,1986

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 4667 ug/kg
SEX/DURATION            : male 8 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
REFERENCE :
   JOAND3 Journal of Andrology.  (Lippincott/Harper, Journal Fulfillment Dept.,
   2350 Virginia Ave., Hagerstown, MD 21740)  V.1-    1980-
   Volume(issue)/page/year: 7,140,1986

Risk Statements
  • R60 May impair fertility 可能降低生殖能力
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S22 Do not breathe dust 不要吸入粉尘；
  • S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；

系列性分类

  1. Neuropeptides - Peptides for Cell Biology
  2. Releasing Factors - Neuropeptides
  3. LH-RH - Releasing Factors
  1. Releasing Factors - Peptides for Cell Biology
  2. LH-RH - Releasing Factors
  1. Releasing Factors - Peptides for Cell Biology
  2. LH-RH - Releasing Factors

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