Ronidazole (1000 ug/mL in Methanol) (1-硝基-1H-咪唑-2-基)甲基氨基甲酸酯

CAS 7681-76-7 MFCD00133801

化学结构图

7681-76-7
SMILES: Cn1c([N+](=O)[O-])cnc1COC(N)=O

化学属性

Mol. FormulaC6H8N4O4
Mol. Weight200
Density1.65
Melting Point168-169°C

别名和识别编码

Chemical NameRonidazole (1000 ug/mL in Methanol)
CAS Number7681-76-7
Synonym (1-Methyl-5-nitroimidazol-2-yl)methyl Carbamate 1-Methyl-2-(carbamoyloxymethyl)-5-nitroimidazole 1-Methyl-2-carbamoyloxymethyl-5 1-Methyl-5-nitro-1H-imidazole-2-methanol 2-Carbamate 1-Methyl-5-nitro-1H-imidazole-2-methanol carbamate ester 1-甲基-2-(氨基甲酰氧甲基)-5-硝基咪唑 1H-Imidazole-2-methanol, 1-methyl-5-nitro-, carbamate (ester) Dugro Ridazole Ridzol Ridzol P Ronida Ronidazol Ronidazol-pharmachim Ronidazole 甲硝咪乙酰胺 罗硝唑
MDL NumberMFCD00133801
PubChem Substance ID5094
EC Number231-675-1
Chemical Name Translation(1-硝基-1H-咪唑-2-基)甲基氨基甲酸酯
Wiswesser Line NotationT5N CNJ A1 B1OVZ ENW
Beilstein Registry Number0886221
LabNetwork Molecule IDLN00195160
InChIInChI=1S/C6H8N4O4/c1-9-4(3-14-6(7)11)8-2-5(9)10(12)13/h2H,3H2,1H3,(H2,7,11)
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分类

  • {SA} Alphabetic, Analytical Standards, Analytical/Chromatography, Chromatography, Drugs & Metabolites, Forensic and Veterinary Standards, Neat Compounds, R
  • {SNA} Additional Standards, Analytical Standards, Antibiotics Standards, Chromatography, Drugs & Metabolites, Forensic and Veterinary Standards, Neat Compounds, Pharmaceuticals, Illicit Drugs & Alcohol, 分析/色谱
  • {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Chromatography, Drugs & Metabolites, Forensic and Veterinary Standards, Neat Compounds, R
  • Pharmaceutic

产品应用

  • 具有抗寄生虫（火鸡鞭毛虫、滴虫病）抗熏浆菌及抗细菌作用三，特别对引起猪赤痢得密螺旋体非常有效。

相关文献及参考

  • Yamada, R., et al.: Biosci. Biotechnol. Biochem., 70, 54 (2006),

安全信息

RTECSNI6803000
WGK Germany2
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
GHS Symbol
Precautionary statements
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
Storage condition -20℃ 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   VMDNAV Veterinarno-Meditsinski Nauki.  Veterinary Science.  (Hemus, Blvd.
   Russki 6, Sofia, Bulgaria) V.1-    1964-  Volume(issue)/page/year:
   22(7),90,1985

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   VMDNAV Veterinarno-Meditsinski Nauki.  Veterinary Science.  (Hemus, Blvd.
   Russki 6, Sofia, Bulgaria) V.1-    1964-  Volume(issue)/page/year:
   22(7),90,1985

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 500 ppm
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 86,243,1981

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 250 mg/kg/5D
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 40,289,1976

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Klebsiella pneumoniae
DOSE/DURATION           : 5 umol/L/20H
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 66,207,1979

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 10 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 3 ug/plate
REFERENCE :
   CBINA8 Chemico-Biological Interactions.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1969-  Volume(issue)/page/year:
   49,27,1984

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 50 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 40,289,1976

Hazard statements

其他信息

  • 无特殊气味。水中溶解度0.25%，微溶于甲醇、乙酸乙酯，不溶于苯、异辛烷、四氯化碳。

系列性分类

  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. R - Alphabetic
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Forensic and Veterinary Standards - Chromatography
  5. Drugs & Metabolites - Forensic and Veterinary Standards
  6. Neat Compounds - Drugs & Metabolites

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