Tomatidine Hydrochloride 盐酸番茄碱
CAS 6192-62-7 MFCD00133866
化学结构图
SMILES: C[C@H]1CC[C@@]2(NC1)O[C@H]1C[C@H]3[C@@H]4CC[C@H]5C[C@@H](O)CC[C@]5(C)[C@H]4CC[C@]3(C)[C@H]1[C@@H]2C.Cl
化学属性
| Mol. Formula | C27 H45 N O2 . Cl H |
|---|---|
| Mol. Weight | 452.11 |
| Melting Point | >281°C (dec.) |
| Boiling Point |
别名和识别编码
| Chemical Name | Tomatidine Hydrochloride |
|---|---|
| CAS Number | 6192-62-7 |
| Synonym | (3?,5?,22?,25S)-Spirosolan-3-ol Hydrochloride 3β-Hydroxy-5α-tomatidane hydrochloride 5α-Tomatidan-3β-ol hydrochloride 3β-Hydroxy-5α-tomatidane hydrochloride 5α-Tomatidan-3β-ol hydrochloride 5 alpha,20 beta(F),22 alpha(F),25 beta(F),27- azaspirostan-3 beta-ol Tomatidine Hydrochloride, >85% {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { |
| MDL Number | MFCD00133866 |
| PubChem Substance ID | 60196284 |
| Beilstein Registry Number | 3920740 |
| Chemical Name Translation | 盐酸番茄碱 |
| InChI | InChI=1S/C27H45NO2.ClH/c1-16-7-12-27(28-15-16)17(2)24-23(30-27)14-22-20-6-5-18-13-19(29)8-10-25(18,3)21(20)9-11-26(22,24)4;/h16-24,28-29H,5-15H2,1-4H3;1H/t16-,17-,18-,19-,20+,21-,22-,23-,24-,25-,26-,27-;/m0./s1 |
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分类
- {SA} Angiogenic Factors, Application Index, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling Enzymes, Cell Signaling and Neuroscience, Cyclooxygenas
- {SNA} Angiogenic Factors, Application Index, Cell Signaling Enzymes, Cyclooxygenase (COX) Enzymes, Cyclooxygenase Inhibitors, Cytokines and Growth Factors, Cytokines, Growth Factors and Hormones, NOS - Nitric Oxide Inhibitors, Nitric Oxide Metabolism, Sonic Hedgehog, 生化试剂, 细胞信号转导和神经科学, 细胞生物学, 酶、抑制剂和底物
- Angiogenic Factors, Application Index, Bioactive Small Molecules,
产品应用
- A steriodal alkaloid structurally similar to Cyclopamine but does not inhibit hedgehog pathway. May be used as a negative control for Cyclopamine and KAAD-Cyclopamine.
相关文献及参考
- Watkins, D.N., et al.: Nature, 422, 313 (2003)
- 1. Mitchell, G., et al., Tomatidine Inhibits the Replication of Staphylococcus aureus Small-Colony Variants in Cystic Fibrosis Airway Epithelial Cells Antimicrob. Agents Chemother. , in press, (2011)
- 2. Chiu, F.L., and Lin, J.K., Tomatidine inhibits iNOS and COX-2 through suppression of NF-kappaB and JNK pathways in LPS-stimulated mouse macrophages FEBS Lett. 582 , 2407-2412, (2008) 摘要
- Huang, S., et al., Activation of the hedgehog pathway in human hepatocellular carcinomas Carcinogenesis 27 , 1334-40, (2006) 摘要
- Liao, X., et al., Aberrant activation of hedgehog signaling pathway in ovarian cancers: effect on prognosis, cell invasion and differentiation Carcinogenesis 30 , 131-40, (2009) 摘要
- Beil. 27 ,IV,1952
安全信息
- H301 Toxic if swallowed 吞食有毒
- H302 Harmful if swallowed 吞食有害
- H331 Toxic if inhaled 吸入中毒
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
- P301+P310
- P301+P312
- P304+P340
- P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
- P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
- P330 Rinse mouth. 漱口
- P403+P233
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
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