D-(?)-Ribose D-(-)-核糖

CAS 50-69-1 MFCD00135453

化学结构图

50-69-1
SMILES: O=C[C@H](O)[C@H](O)[C@H](O)CO

化学属性

Mol. FormulaC5H10O5
Mol. Weight150.13
Density1.681
Melting Point95°C
TSCAYes
Stability易吸潮
SolubilityH2O: 0.1 g/mL, clear, colorless to light yellow
Refractive index-21 ° (C=1, H2O)
Boiling Point375.4°C at 760 mmHg

别名和识别编码

Chemical NameD-(?)-Ribose
CAS Number50-69-1
Alfabeta NameRIBOSE D-
MDL NumberMFCD00135453
Synonym D-Ribose(mixture of isomers) {LY} D-Ribose(mixture of isomers) {} {LY} D-Ribose(mixture of isomers) {} {} {LY} D-Ribose(mixture of isomers) {} {} {} {LY} D-Ribose(mixture of isomers) {} {} {} {} {} {} {} {} {LY} D-Ribose(mixture of isomers) {} {} {} {} {} {LY} D-Ribose(mixture of isomers) {} {} {} {} {} {} {LY} D-Ribose(mixture of isomers) {} {} {} {} {} {} {} {LY} D-Ribose(mixture of isomers) {} {} {} {} {} {} {} {} {LY} D-Ribose(mixture of isomers) {} {} {} {} {} {} {} {} {} {LY} D-Ribose(mixture of isomers) {} {} {} {} {} {} {} {} {} {} {LY} D-Ribose(mixture of isomers) {} {} {} {} {} {} {} {} {} {} {} {LY} D-Ribose(mixture of isomers) {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {LY} D-Ribose(mixture of isomers) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} D-Ribose(mixture of isomers) {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} D-Ribose(mixture
EC Number200-059-4
Beilstein Registry Number1723081
PubChem Substance ID5311110
Reaxys-RN1904878
Merck Number8204
Chemical Name TranslationD-(-)-核糖
LabNetwork Molecule IDLN00173975
InChIInChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5-/m0/s1
Canonical SMILESO=C[C@@H]([C@@H]([C@@H](CO)O)O)O
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分类

  • Allium cepa (Onion), Carbohydrate Chemistry, Carbohydrate Derivatives, Carbohydrates, Chemical Biology, Chemical Synthesis, Functional Foods, Nutrition Research, Phytochemicals by Plant (Food/Spice/Herb), Simple sugars
  • {SNA} Carbohydrates, Functional Foods, Simple sugars, 细胞生物学, 营养研究
  • {SNA} Carbohydrates, Functional Foods, Nutrition Research, Simple sugars, 细胞生物学
  • {SNA} Allium cepa (Onion), Carbohydrate, Carbohydrate Library Collection, Carbohydrates, Carbohydrates A to Z, Carbohydrates P-Z, Functional Foods,

产品应用

  • D-核糖是生物体内遗传物质——核酸的重要组成物质,在核苷类物质、蛋白质、脂肪代谢中处于枢 纽位置,具有重要的生理功能及广阔的应用前景。
  • D-核糖作为生物体内存在于所有细胞中的天然成份,与腺苷酸的形成和ATP的再生有密切关系,是生命代谢最基本的能量来源之一。在心脏和骨络肌代谢中起关键作用,能够促进局部缺血组织、局部缺氧组织的恢复。
  • 核酸类药物是当今人类治疗病毒、肿瘤、艾滋病的重要手段,D-核糖是许多核酸类药物的重要中间体,可用于三氮唑核苷、腺苷、胸苷、胞苷、氟腺嘧啶核苷、2-甲基腺苷、威他毒素、吡唑毒素、腺苷旦氨酸等许多药物的生产中。

相关文献及参考

  • For an evaluation of the potential of D-ribose as an enantiopure building block for construction of the C-ring of taxol, see: J. Org. Chem., 60, 7849 (1995).
  • Merck: 14,8204
  • Merck: 14,8204 Beilstein:1(4)4214
  • Ostrowski, S., et al.: Science, 305, 71 (2004),
  • Short: II/27B
  • [1]. Hong J, et al. D-ribose induces nephropathy through RAGE-dependent NF-κB inflammation. Arch Pharm Res. 2018 Aug;41(8):838-847.

安全信息

Warnings IRRITANT
Signal word Warning
GHS Symbol
WGK Germany3
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触;
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛,皮肤或衣服。
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RTECSVJ2275000
Storage condition 2-8°C {LY} 2-8°C 2-8℃保存,易吸潮 Hygroscopic {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY}
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 30 mmol/L
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 180,246,1985

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 50 mmol/L
REFERENCE :
   BBRCA9 Biochemical and Biophysical Research Communications.  (Academic
   Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1959-
   Volume(issue)/page/year: 138,673,1986

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intrauterine
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 5045 ug/kg
SEX/DURATION            : female 2 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
REFERENCE :
   SCYYDZ Shengzhi Yu Biyun.  Reproduction and Contraception.  (China
   International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) 1980-
    Volume(issue)/page/year: 11(4),7,1991

其他信息

  • 下游产品:催杀 --> 催杀 --> 利巴韦林 --> 辅酶 A
  • 食品添加剂最大允许使用量最大允许残留量标准:添加剂中文名称 允许使用该种添加剂的食品中文名称 添加剂功能 最大允许使用量(g/kg) 最大允许残留量(g/kg) d-核糖 食品 食品用香料 用于配制香精的各香料成分不得超过在GB 2760中的最大允许使用量和最大允许残留量
  • 敏感性:Hygroscopic
  • 外观性质:白色结晶性粉末,具有清凉口感的甜味,在水中的溶解度很大。熔点: 88-92 °C
  • D-核糖价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 63010483 D-核糖(+4℃) 5g 130元 2011/08/23 63010481 D-核糖(+4℃) 5g 130元 2011/04/16 R0025 D-(-)-核糖 D-(-)-Ribose 250G 3670元
  • 上游原料:D-无水葡萄糖
  • 用途一:用作医药原料、保健品、中间体、食品添加剂等
  • Alfa Aesar:D-(-)-核糖,98% D-(-)-Ribose, 98%(50-69-1)
  • 图谱信息:D-核糖(50-69-1)红外图谱(IR1) D-核糖(50-69-1)红外图谱(IR2) D-核糖(50-69-1)质谱(MS)
  • 比旋光度:-20.8 ° (c=4, H2O)
  • 具有清凉口感的甜味,在水中的溶解度很大。
  • F:3-10
  • 用途二:D-核糖是生物体内遗传物质――核酸的重要组成物质,在核苷类物质、蛋白质、脂肪代谢中处于枢 纽位置,具有重要的生理功能及广阔的应用前景。D-核糖作为生物体内存在于所有细胞中的天然成份,与腺苷酸的形成和ATP的再生有密切关系,是生命代谢最基本的能量来源之一。在心脏和骨络肌代谢中起关键作用,能够促进局部缺血组织、局部缺氧组织的恢复。核酸类药物是当今人类治疗病毒、肿瘤、艾滋病的重要手段,D-核糖是许多核酸类药物的重要中间体,可用于三氮唑核苷、腺苷、胸苷、胞苷、氟腺嘧啶核苷、2-甲基腺苷、威他毒素、吡唑毒素、腺苷旦氨酸等许多药物的生产中。
  • MSDS 信息:D-Ribose(50-69-1).msds
  • Sigma Aldrich:50-69-1(sigmaaldrich)
  • 海关编码:29400090
  • FEMA:3793
  • TCI Shanghai:D-核糖 D-(-)-Ribose,>;98.0%(GC)(50-69-1)
  • MOL 文件:50-69-1.mol
  • Acros Organics:D(-)-核糖 D(-)-Ribose, 99.5+%(50-69-1)

系列性分类


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