Endosulfan 硫丹
CAS 115-29-7 MFCD00137651
化学结构图
SMILES: O=S1OCC2C(CO1)C1(Cl)C(Cl)=C(Cl)C2(Cl)C1(Cl)Cl
化学属性
| Mol. Formula | C9H6Cl6O3S |
|---|---|
| Mol. Weight | 407 |
| Melting Point | 70-100°C |
| Solubility | 不溶于水，溶于多数有机溶剂。 |
| Flash Point | -26 °C |
| Density | 1.94 |
别名和识别编码
| Chemical Name | Endosulfan (Mixture of Diastereomers) |
|---|---|
| CAS Number | 115-29-7 |
| PubChem Substance ID | 24862761 |
| EC Number | 204-079-4 |
| Beilstein Registry Number | 2062338 |
| MDL Number | MFCD00137651 |
| Synonym | HOE 2671 Thiodan 35EC 5,9-Metha {Chem 赛丹 6,7,8,9,10,10-HEXACHLORO-1,5,5A,6,9,9A-HEXAHYDRO-6,9-METHANO-2,4,3-BENZO-DIOXATHIEPIN-3-OXIDE 硕丹 1,2,3,4,7,7-Hexachloro-1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3-benzodioxathiepin-3-oxide OMS 570 HOE 2671(R) 1, 1,2,3,4,7,7-Hexachlorobicyclo(2.2.1)hepten-5,6-bioxymethylenesulfite 5-Norbornene-2,3-dimethanol, 1,4,5,6,7,7-hexachloro-, cyclic sulfite Thiotox (insecticide) {Chemica 1,4,5,6,7,7-HEXACHLORO-5-NORBORENE-2,3-DIMETHANOL Thiotox Endocel (1,4,5,6,7,7-六氯-8,9,10-三降冰-5-烯-2,3-亚基双亚甲基)亚硫酸酯 Chlorthiepin FAN 35%硫丹乳油 Thiodan {Ch endosulfan Hildan Benzoepin 1,2,3,4,7,7-Hexachlor-8,9,10-trinorborn-2-en-5,6-ylendimethylsulfit Malix 6,7,8,9,10,10-hexachloro-1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3-benzodioxathiepin 3-oxide ENDOSULFAN 1,2,3,4,7,7-六氯双环[2,2,1]庚烯-(2)-双羟甲基-5,6-亚硫酸酯 THIODAN 6,9-Methano-2,4,3-benzodioxathiepin, 6,7,8,9,10,10-hexachloro-1,5,5a,6,9,9a-hexahydro-, 3-oxide, stereoisomer Endosulfan A Tiovel BIO 5,462 Cyclodan Beosit 硫丹 {uni {C 1,2,3,4,7,7-hexachloro-8,9,10-trinorborn-2-en-5,6-ylened Endosulfan Phaser CYCLODAN(R) CHLORTHIEPIN(R) 1,2,3,4,7,7-Hexachloro-1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3-b Niagara 5462 Devisulphan {Che AFIDANIL alpha,beta-1,2,3,4,7,7-Hexachlorobicyclo(2.2.1)-2-heptene-5,6-bisoxymethylene sulfite |
| Chemical Name Translation | 硫丹 |
| Merck Number | 13,3608 |
| Wiswesser Line Notation | T C755 A EOSO KUTJ AG AG BG FO JG KG LG |
信息真实价格透明
资金保障
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信息真实价格透明
资金保障
专业采购外包团队在线服务
品牌质保精细包装
现货库存
一流品牌服务
分类
- {Chemicalbook} 农药: 杀虫（螨）剂: 有机杂环及其他杀虫剂
- {uni_hamburg} no charge; oxygen heterocycle; sulfur heterocycle; carbocycle; alicycle; large ring; fused rings; 5ring; 6ring; 7ring; 10ring; 11ring; 1fragment
- 2000/60/EC, Acaricides, Alpha sort, Alphabetic, Analytical Standards, Analytical/Chromatography, Chromatography, Cyclodienes, E, E-G, EA - EO, EPA, Endocrine Disruptors (Draft), Environmental Standards, European Community: ISO, DIN and DL 152, Insecticides, Method Specific, Oeko-Tex Standard 100, Pesticides, Pesticides & Metabolites
- {SNA} 2000/60/EC, Acaricides, Alphabetic, Analytical Standards,
产品应用
- 对昆虫具有触杀及胃毒作用，可用于多种作物上防治蚜虫、菜青虫、棉铃虫、天牛等害虫；对螨类、蛞蝓亦有效。
相关文献及参考
- Short: III/20b
- Short: EINECS
- Merck:13,3608
安全信息
GHS Symbol
- H315 Causes skin irritation 会刺激皮肤
- H304 May be fatal if swallowed and enters airways 吞食和进入呼吸道可能致命
- H336 May cause drowsiness or dizziness 肯能导致嗜睡或头晕
- H411 Toxictoaquaticlifewithlonglastingeffects 对水生生物有毒性并具有长期影响。
- H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
- H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
- H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
- H300+H310+H330
- H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
- P273 Avoid release to the environment. 避免释放到环境中。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P301+P310
- P281 Use personal protective equipment as required. 使用所需的个人防护装备。
- P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
- P331 Do NOT induce vomiting.. 不要催吐。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P284 Wear respiratory protection.? 佩戴呼吸保护装置。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
- S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
- S62 If swallowed, do not induce vomiting: seek medical advice immediately and show this container or label where possible 吞食后不要催吐：立即求医并出示该容器或标签；
- S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
- S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
- S63
- R26/28 Very toxic by inhalation and if swallowed 吸入及吞食都有剧毒
- R21 Harmful in contact with skin 与皮肤接触有害
- R50/53
- R24/25 Toxic in contact with skin and if swallowed 皮肤接触及吞食都有毒
- R48/20
- R11 Highly flammable 非常易燃
- R62 Possible risk of impaired fertility 有削弱生殖能力的危险
- R67 Vapours may cause drowsiness and dizziness 蒸汽可能导致嗜睡和昏厥
- R51/53
- R65 Harmful: may cause lung damage if swallowed 若吞咽可能伤害肺部器官
- R38 Irritating to skin 刺激皮肤
- R36 Irritating to eyes 刺激眼睛
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 330 mg/kg/78W-I TOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB223-159
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2 mg/kg TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB223-159
{hTYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 76700 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,332,1991
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 18 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARSIM* Agricultural Research Service, USDA Information Memorandum. (Beltsville, MD 20705
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Human - woman DOSE/DURATION : 6 uL/kg TOXIC EFFECTS : Behavioral - muscle weakness Liver - liver function tests impaired Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) REFERENCE : JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982- Volume(issue)/page/year: 34,447,1996
TYPE OF TEST
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Bird - duck DOSE/DURATION : 33 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DOEAAH Down to Earth. (Dow Chemical USA, Agricultural Products Dept., Midland, MI 48640) V.1- 1945- Volume(issue)/page/year: 35,25,1979
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous S
TYPE OF TEST : Cytogenetic analysis ROUTE OF EXPOSURE : Intraperitoneal TEST SYSTEM : Rodent - hamster DOSE/DURATION : 8 mg/kg REFERENCE : ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 58,152,1986
TYPE OF TEST : Mutation in mammalian somatic cells TEST SYSTEM : Rodent - mouse Lymphocyte DOSE/DURATION : 18600 ug/L REFERENCE : EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 12,85,1988
TYPE OF TEST : Cytogenetic analysis ROUTE OF EXPOSURE : Unreported TEST SYSTEM : Rodent - mouse DOSE/DURATION : 1 mg/kg REFERENCE : TGANAK Tsitologiya i Genetika. Cytology and Genetics. For English translation, see CYGEDX. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967- Volume(issue)/page/year: 16(1),45,1982
TYPE OF TEST : Sperm Morphology ROUTE OF EXPOSURE : Intraperitoneal TEST SYSTEM : Rodent - mouse DOSE/DURATI
TYPE OF TEST : Cytogenetic analysis ROUTE OF EXPOSURE : Oral TEST SYSTEM : Rodent - mouse DOSE/DURATION : 32 mg/kg REFERENCE : IMSCE2 IRCS Medical Science. (Lancaster, UK) V.12-14, 1984-86. For publisher information, see MSCREJ. Volume(issue)/page/year: 14,1125,1986
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Yeast - Saccharomyces cerevisiae DOSE/DURATION : 100 mg/L REFERENCE : TGANAK Tsitologiya i Genetika. Cytology and Genetics. For English translation, see CYGEDX. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967- Volume(issue)/page/year: 18,455,1984
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 600 mg/kg SEX/DURATION : male 60 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - other effects on male REFERENCE : TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 18(Suppl 1),139,1983
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 45 mg/kg SEX/DURATION : female 6-14 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 42,150,1978
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 125 mg/kg SEX/DURATION : male 13 week(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct REFERENCE : BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966- Volume(issue)/page/year: 58,79,1997
其他信息
- {Chem
- 产物为棕色，两种主体异构体的混合物(α-体:β-体=70:30)，难溶于水，易溶于二氯甲烷、甲苯中
- 可燃性危险特性:受热放出有毒氯化物、氧化硫气体;遇酸、碱、潮气分解有毒氧化硫气体
- 用途二:有机氯杀虫剂。具有触杀和胃毒作用，杀虫谱广，持效期长。气温高于20℃时，也可通过其蒸气起杀虫作用。可用于棉花、果树、蔬菜、烟草、马铃薯及苜蓿等作物
- 上游原料:氢氧化钠 --> 氧氯化硫 --> 甲苯 --> 氯 --> 茂 --> 六氯环戊二烯 --> 1,4-丁烯二醇 --> 顺式-1,2-二羟甲基乙烯 --> 硫丹醇
- 中毒症状:症状与体征是其对神经系统的刺激作用所致，如头痛、眩晕
- 急性毒性:口服-大鼠 LD50: 18 毫克/公斤; 口服-小鼠 LD50: 7.36 毫克/公斤
- MOL 文件:115-29-7.mol
- Sigma Aldrich:115-29-7(sigmaaldrich)
- 两种主体异构体的混合物(α-体:β-体=70:30)，难溶于水，易溶于二氯甲烷、甲苯中
- 毒性:大鼠急性经口LD 50 为40～50mg/kg[原药22.7～160mg/kg(雄），22.7mg/kg(雌)]。大鼠急性经皮LD 50 >500mg/kg，兔359mg/kg。大鼠吸入LC 50 为34.5mg/l (雄，4h)、12.6mg/L (雌，4h)。对皮肤和眼睛有轻度刺激，无致敏性。大鼠13周喂养试验无作用剂量10mg/kg饲料或0.7mg/kg体重。大鼠2年喂养试验无作用剂量为15mg/kg饲料或0.6～0.7mg/kg体重。致突变试验阴性，大鼠2代繁殖无不良影响。试验条件下未见致癌作用。母鸡试验未见迟发性神经毒性。联合国粮农组织和世界卫生组织联席会议推荐ADI为0.006mg/kg体重（1989年）。药剂对鱼类高毒，LC 50 约0.002mg/L(96h)，野鸭急性经口LD 50 为200～750mg/kg，野鸡620～1000mg/kg，鹌鹑85～106mg/kg。蜜蜂接触LD 50 为7.1μg/只，经口LD 50 为6.9μg/只。
- 产品特性:无累积性毒性、用于旱地的有机氯杀虫剂。对高等动物毒性较高，对鱼高毒。对蜜蜂安全。具有胃毒和触杀作用，杀虫广谱，残效较长。
- 方法一:硫丹由六氯环戊二烯与1，4-丁烯二醇加热反应，保温10h，冷却，过滤，洗涤制得硫丹醇，再将硫丹醇和溶剂加热到一定温度，滴加氯化亚砜，滴毕，维持反应1h，减压脱氯化氢，冷却、结晶过滤制得硫丹。详见参考文献[3]。
- 外观性质:二种异构体的混合物，是棕色结晶。
- 职业标准:纯品 TWA 0.1 毫克/立方米; STEL 0.3 毫克/立方米
- 急救治疗:[1]无特殊解毒剂，如经口摄入要催吐 [2]尽可能保持病人安静，控制病人激动。清醒时，可给予常用剂量的巴比妥与其它镇静剂 [3]注意维持呼吸，如有衰竭使用人工呼吸 [4]禁忌用肾上腺素或阿托品。
- MSDS 信息:硫丹(115-29-7).msds
- 用途一:用于防治棉花、果树、大豆、蔬菜、茶及烟草等各种作物害虫
- 灭火剂:砂土、干粉、泡沫
- 储运特性:库房通风低温干燥; 与食品原料分开储运
- 类别:农药
- 毒性分级:剧毒
- 用途:硫丹适用于防治棉花、果树 、蔬菜、烟草、马铃薯及苜蓿上的多种咀嚼式和刺吸式口器害虫。对作物不易产生药害。常用20%乳油300~500倍液喷雾，防治棉铃虫、红铃虫、棉卷叶虫、金刚钻、金龟子、梨小食心虫、桃小食心虫、粘虫、蓟马和叶蝉等。用500~1000倍液，可防治棉花 和果树上的蚜、螨。用200倍液灌根防治地老虎效果也很好。残留限量为2毫克/千克，作物收获前三周禁止使用，对鱼高毒，不能在水田使用。
- 用途二:有机氯杀虫剂。具有触杀和胃毒作用，杀虫谱广，持效期长。气温高于20℃时，也可通过其蒸气起杀虫作用。可用于棉花、果树、蔬菜、烟草、马铃薯及苜蓿等作物，防治棉铃虫、红铃虫、棉卷叶蛾、金刚钻、金龟子、梨小食
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