Naringin 柚皮苷

CAS 10236-47-2 MFCD00148888

化学结构图

10236-47-2
SMILES: C[C@@H]1O[C@@H](O[C@H]2[C@H](OC3C=C(O)C4C(=O)C[C@H](OC=4C=3)C3C=CC(O)=CC=3)O[C@H](CO)[C@@H](O)[C@@H]2O)[C@H](O)[C@H](O)[C@H]1O

化学属性

Mol. FormulaC27H32O14
Mol. Weight581
Melting Point166 ºC
TSCAYes
Density1.66

别名和识别编码

Chemical NameNaringin
Synonym Naringenine-7-rhamnosidoglucoside 柚皮甙
MDL NumberMFCD00148888
PubChem Substance ID87573467
Beilstein Registry Number102012
EC Number233-566-4
CAS Number10236-47-2
Merck Number6425
Chemical Name Translation柚皮苷
Reaxys-RN102012
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分类

  • {SNA} Carbohydrates A to Z, Carbohydrates M-O, Citrus aurantium (Seville orange), Flavonoids, Flavonols, and Flavanols, Phytochemicals by Chemical Classification, Phytochemicals by Plant (Food/Spice/Herb), 生化试剂, 碳水化合物, 细胞生物学,
  • {SNA} Carbohydrates A to Z, Carbohydrates M-O, Citrus aurantium (Seville orange), Flavonoids, Flavonols, and Flavanols, Phytochemicals by Chemical Classification, Phytochemicals by Plant (Food/Spice/Herb), 生化试剂, 碳水化合物, 细胞生物学, 营养研究
  • {SNA} Natural Dyes, Stains and Dyes, 细胞生物学, 血液学和组织学
  • {SNA} Citrus aurantium (Seville orange), Flavonoids, Flavonols, and Fl

产品应用

  • 苦味剂。本品经水解加氢所得柚苷二氢查耳酮为甜味剂，甜度约为蔗糖的150倍。

相关文献及参考

  • [2]. Raha S, et al. Naringin induces autophagy-mediated growth inhibition by downregulating the PI3K/Akt/mTOR cascade via activation of MAPK pathways in AGS cancer cells. Int J Oncol. 2015 Sep;47(3):1061-9.
  • [3]. Kulasekaran G, et al. Neuroprotective efficacy of naringin on 3-nitropropionic acid-induced mitochondrial dysfunction through the modulation of Nrf2 signaling pathway in PC12 cells. Mol Cell Biochem. 2015 Nov;409(1-2):199-211.
  • [4]. Wang D, et al. Naringin Improves Neuronal Insulin Signaling, Brain Mitochondrial Function, and Cognitive Function in High-Fat Diet-Induced Obese Mice. Cell Mol Neurobiol. 2015 Oct;35(7):1061-71.
  • Merck:14,6424
  • Merck:14,6424 Beilstein:18,528
  • [1]. Chen F, et al. Naringin Alleviates Diabetic Kidney Disease through Inhibiting Oxidative
  • [1]. Chen F, et al. Naringin Alleviates Diabetic Kidney Disease through Inhibiting Oxidative Stress and Inflammatory Reaction. PLoS One. 2015 Nov 30;10(11):e0143868.

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
RTECSQN6340000
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘；
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S37 Wear suitable gloves 戴适当手套；
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
Hazard Codes Xi
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EKMMA8 Eksperimentalna Meditsina i Morfologiya.  (Hemus, Blvd. Russki 6,
   Sofia, Bulgaria) V.1-    1962-  Volume(issue)/page/year: 19,207,1980

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EKMMA8 Eksperimentalna Meditsina i Morfologiya.  (Hemus, Blvd. Russki 6,
   Sofia, Bulgaria) V.1-    1962-  Volume(issue)/page/year: 19,207,1980

系列性分类

  1. Life Science 生命科学
  2. Nutrition Research 营养研究
  3. Phytochemicals by Chemical Classification - Nutrition Research
  4. Plant Extracts - Phytochemicals by Chemical Classification
  1. Life Science 生命科学
  2. Hematology and Histology 血液学和组织学
  3. Stains and Dyes - Hematology and Histology
  4. Natural Dyes - Stains and Dyes
  1. Life Science 生命科学
  2. Nutrition Research 营养研究
  3. Phytochemicals by Plant (Food/Spice/Herb) - Nutrition Research
  4. Citrus aurantium (Seville orange) - Phytochemicals by Plant (Food/Spice/Herb)
  1. Analytical & Chromatography 分析化学与色谱
  2. Syringes
  3. GC Manual Syringes - Syringes
  4. Gas/Liquid sampling - GC Manual Syringes
  5. Syringes for gas sampling, 1-100 mL - Gas/Liquid sampling
  6. Hamilton GASTIGHT® Syringes, 1000 Series - Syringes for gas sampling, 1-100 mL
  1. Life Science 生命科学
  2. Biochemistry / Glyco-Chemistry
  3. Flavonoids
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Biochemicals and Reagents
  4. Stains and Dyes
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Biochemicals Found in Plants
  4. Aromatic Compounds
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Hemotology and Histology
  4. Stains and Dyes
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Hematology and Histology
  4. Stains and Dyes
  5. Certified Stains & Dyes
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Nutrition Research
  4. Biochemicals Found in Plants
  5. Aromatic Compounds
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Biochemicals and Reagents
  4. Stains and Dyes
  5. Natural Dyes
  1. Medical Research Areas
  2. Metabolism
  3. Cytochrome P450  (细胞色素P450)
  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)

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