Tartrazine 柠檬黄

CAS 1934-21-0 MFCD00148908

化学结构图

1934-21-0
SMILES: O=C([O-])C1=NN(c2ccc(S(=O)(=O)[O-])cc2)C(=O)C1N=Nc1ccc(S(=O)(=O)[O-])cc1.[Na+].[Na+].[Na+]

化学属性

Mol. FormulaC16H9N4Na3O9S2
Mol. Weight534
TSCAYes
Melting Point>300
Solubility260 G/L (30 ºC)
Density1.93
Stability易吸潮

别名和识别编码

Chemical NameTartrazine
CAS Number1934-21-0
Synonym ######## 1-(4-磺酸苯基)-4-(4-磺酸苯基偶氮)-5-吡唑啉酮-3-羧酸三钠盐 3-羧基-5-羟基-(对苯磺酸)-4-(对苯磺酸偶氮)吡唑三钠盐 5-HYDROXY-1-(P-SULFOPHENYL)-4-[(P-SULFOPHENYL)AZO]PYRAZOLE-3-CARBOXYLIC ACID TRISODIUM SALT A.F. Yellow No. 4 ACID YELLOW 23 Acid Yellow 23,C.I. 19140 Acid Yellow T Acilan Yellow GG Barium, Tartrazine C.I.19140; Tartrazine; Food Yellow 4; Trisodium 1-(4-sulfonatophenyl)-4-(4-sulfonatophenylazo)-5-pyrazolone-3-carboxylate C.I.酸性黄23 CI 19140 CI ACID YELLOW 23 Canacert tartrazine E102 FD AND C YELLOW 5 FD AND C YELLOW NO 5 FD and C Yellow No. 5 FILTER YELLOW FOOD YELLOW NO 4 KITON YELLOW T LAKE TARTRAZINE TARTAZINE TARTRAZINE TARTRAZINE O {PubChem}
Beilstein Registry Number25,252
MDL NumberMFCD00148908
EC Number217-699-5
PubChem Substance ID164825
Merck Number9072
Chemical Name Translation柠檬黄
Reaxys-RN6629178
Wiswesser Line NotationT5NNJ AR DSWO& CVO DNUNR DSWO& EQ &-NA- 3
LabNetwork Molecule IDLN00201974
InChIInChI=1S/C16H12N4O9S2.3Na/c21-15-13(18-17-9-1-5-11(6-2-9)30(24,25)26)14(16(22)23)19-20(15)10-3-7-12(8-4-10)31(27,28)29;;;/h1-8,13H,(H,22,23)(H,24,25,26)(H,27,28,29);;;/q;3*+1/p-3
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分类

  • {SNA} All Alphabetically Sorted, All alphabetical sorted, Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Chromatography, Colors, E numbers (Food Additives), E100–E199 (color additives), E102, Food & Beverage Standards, Food Color Additives, T, TA - TE, Trigger for Food Allergies & Intolerances
  • {SNA} All Alphabetically Sorted, All alphabetical sorted, Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Chromatography, Colors, E numbers (Food Additives), E100–E199 (color additives),
  • {SNA} Additional

产品应用

  • 用于食品，医药，日用化妆品的着色。

相关文献及参考

  • Tanaka, T., et al.: Food Chem. Toxicol., 44, 179 (2006),
  • Rowe, K.S., et al.: J. Pedriatics, 125, 691 (1994),
  • Merck: 14,9072
  • Merck: 14,9072 Beilstein: 25,IV,1756

安全信息

Hazard statements
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难
GHS Symbol
WGK Germany1
Precautionary statements
  • P233 Keep container tightly closed. ?保持容器密闭。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P285 In case of inadequate ventilation wear respiratory protection. 在通风不足的情况下，戴呼吸防护。
  • P302+P352
  • P302+P352+P333+P313+P362+P364
  • P304+P340
  • P304+P340+P342+P311
  • P304+P341
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P333+P313
  • P333+P317
  • P342+P311
  • P342+P316
  • P362+P364
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P403 Store in a well-ventilated place. 储存在通风良好的地方。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard Codes Xn
RTECSUQ6400000
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Signal word Danger
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
Risk Statements
  • R42/43
Storage condition 充氩保存 Hygroscopic 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 12750 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FAONAU FAO Nutrition Meetings Report Series.  (Rome, Italy)  No.?-57,
   1948-77.  Discontinued.  Volume(issue)/page/year: 38B,88,1966

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APFRAD Annales Pharmaceutiques Francaises.  (SPPIF, B.P.22, F-41353 Vineuil,
   France)  V.1-    1943-  Volume(issue)/page/year: 15,402,1957

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 14 ug/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - paresthesis
   Musculoskeletal - changes in teeth and supporting structures
REFERENCE :
   ANAEA3 Annals of Allergy.  (American College of Allergists, POB 20671,
   Bloomington, MN 55420) V.1-    1943-  Volume(issue)/page/year: 17,719,1959

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FAONAU FAO Nutrition Meetings Report Series.  (Rome, Italy)  No.?-57,
   1948-77.  Discontinued.  Volume(issue)/page/year: 38B,88,1966

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 100 mg/L
REFERENCE :
   SOGEBZ Soviet Genetics.  English translation of GNKAA5.  (Plenum Pub. Corp.,
   233 Spring St., New York, NY 10013)  V.2-    1966- Volume(issue)/page/year:
   11,528,1975

TYPE OF TEST            : Body fluid assay
TEST SYSTEM             : Rodent - rat Bacteria - Salmonella typhimurium
DOSE/DURATION           : 1500 mg/kg
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   60,328,1987

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Mammal - species unspecified Fibroblast
DOSE/DURATION           : 5 mg/L
REFERENCE :
   FCTOD7 Food and Chemical Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.20-    1982- Volume(issue)/page/year:
   20,461,1982

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Fibroblast
DOSE/DURATION           : 2500 mg/L
REFERENCE :
   FCTOD7 Food and Chemical Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.20-    1982- Volume(issue)/page/year:
   22,623,1984

TYPE OF TEST            : Specific locus test
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 600 ppm
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 224,479,1989

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 2100 mg/L
REFERENCE :
   GMCRDC Gann Monograph on Cancer Research.  (Plenum Pub. Corp., 233 Spring
   St., New York, NY 10013) No

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 20 gm/kg
SEX/DURATION            : female 7-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 24,399,1982

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 18500 mg/kg
SEX/DURATION            : female 7-22 day(s) after conception
                          lactating female 21 day(s) post-birth
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - blood and lymphatic
   systems (including spleen and marrow)
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
   Reproductive - Effects on Newborn - behavioral
REFERENCE :
   JTEHD6 Journal of Toxicology and Environmental Health.  (Hemisphere Pub.,
   1025 Vermont Ave., NW, Washington, DC 20005)  V.1-    1975/76-
   Volume(issue)/page/year: 2,1211,1977

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1280 mg/kg
SEX/DURATION            : female 7-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
   alive at weaning per # alive at day 4)
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 24,399,1982

其他信息

  • 酸性黄 23价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 71020880 肼黄 5g 28元 2011/04/16 F0088 酸性黄 23 Acid Yellow 23 25G 233元 2011/04/16 F0144 食品黄4(柠檬黄) Food Yellow No. 4 25G 862元
  • 毒害物质数据:1934-21-0(Hazardous Substances Data)
  • 色指数:19140
  • 图谱信息:酸性黄 23(1934-21-0)红外图谱(IR2) 酸性黄 23(1934-21-0)核磁图( 1 HNMR) 酸性黄 23(1934-21-0)红外图谱(IR1)
  • 生产方法:由双羟基酒石酸与苯肼对磺酸缩合，或对氨基苯磺酸经重氮化后与1-(4’-磺基苯)-3-羧基-5-吡唑酮偶合，经氯化钠盐析后精制而得。
  • 稳定性:Stable. Hygroscopic. Incompatible with strong oxidizing agents.
  • MOL 文件:1934-21-0.mol
  • 用途:作为食品着色剂，我国规定可用于果汁(味)饮料类、碳酸饮料、配制酒、青梅、虾(味)片、浸渍小菜、红绿丝糖果、糕点上彩装和西瓜酱罐头中，最大使用量为0.1g/kg；在植物蛋白饮料、乳酸菌饮料中最大使用量为0.05g/kg；在冰淇淋中最大使用量为0.02g/kg。
  • 参考质量标准:GB 4481.1—1999 柠檬黄60 柠檬黄85 含量/% ≥60.0 ≥185.0 干燥减量/% ≤10.0 — 干燥减量、氯化物(以氯化钠计)及硫酸盐(以硫酸钠计)总量/% 一 ≤15.0 水不溶物/% ≤0.30 ≤0.30 副染料/% ≤1.0 ≤1.0 砷(以As计)/% ≤0.0001 ≤0.0001 重金属(以Pb计)/% ≤0.001 ≤0.001 GB 4481.2—1994(柠檬黄铝色淀) 含量/%@≥10.0 盐酸和氨水不溶物/%@≤0.5 水溶性氯化物及硫酸/%@≤2.0副染料/%@≤0.5 水分及挥发物/%@≤30 重金属(以Pb 计) /%@≤0.002 砷(As)/%@≤0.0003 钡(Ba)/%@≤0.05
  • EPA化学物质信息:1H-Pyrazole-3-carboxylic acid, 4,5-dihydro-5-oxo-1-(4-sulfophenyl)- 4-[(4-sulfophenyl)azo]-, trisodium salt(1934-21-0)
  • 21℃时的溶解度为：水11.8%，10%的乙醇9%，50%的乙醇3%，溶于甘油，丙二醇，不溶于油脂，属偶氮型酸性染料，耐热性，耐酸性，耐光性，耐盐性均好，在柠檬酸及酒石酸等溶液中很安定。耐氧化性较差，遇碱稍变红，还原时褪色。
  • RTECS号:UQ6400000
  • 敏感性:Hygroscopic

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  1. Chemical Synthesis 化学合成
  2. Asymmetric Synthesis 不对称合成
  3. Chiral Building Blocks 手性分子砌块
  4. Complex Molecules - Chiral Building Blocks
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Nitrogen Compounds 氮化合物
  5. Azo/Diazo Compounds - Nitrogen Compounds
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Food & Beverage Standards - Chromatography
  5. E numbers (Food Additives) - Food & Beverage Standards
  6. E100–E199 (colors) - E numbers (Food Additives)
  1. Analytical & Chromatography 分析化学与色谱
  2. Food Colors by Food Sanitation Law in Japan
  1. Functional Group 官能团索引
  2. azo compound
  1. Functional Group 官能团索引
  2. carboxylic acid salt