1H-Pyrrole-2-acetic acid,1-methyl-5-(4-methylbenzoyl)-, sodium salt, dihydrate
CAS 64490-92-2 MFCD00150761
化学结构图
SMILES: O.O.[Na+].CC1C=CC(=CC=1)C(=O)C1=CC=C(CC([O-])=O)N1C
化学属性
| Mol. Formula | C15H18NNaO5 |
|---|---|
| Mol. Weight | 315 |
| TSCA | No |
别名和识别编码
| Chemical Name | Tolmetin sodium salt dihydrate |
|---|---|
| CAS Number | 64490-92-2 |
| Synonym | Sodium tolmetin dihydrate 1-Methyl-5-(p-toluoyl)pyrrole-2-acetic acid sodium salt dihydrate 5-[(p-Tolyl)carbonyl]-1-methylpyrrole-2-acetic Acid Sodium Dihydrate Tolmetin sodium salt dihydrate 1-Methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetic Acid Sodium Dihydrate Tolmetin sodium dihydrate Tolumetin sodium dihydrate Sodium 1-methyl-5-p-toluoylpyrrole-2-acetate dihydrate 1-Methyl-5-p-toluoylpyrrole-2-acetic Acid Sodium Dihydrate |
| MDL Number | MFCD00079607 |
| PubChem Substance ID | 24900403 |
| EC Number | 252-687-3 |
| Merck Number | 14,9518 |
| Wiswesser Line Notation | T5NJ A1 BVR D1& E1VO &-NA- &QH 2 |
| Chemical Name Translation |
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分类
- Aromatics
- Heterocycles
- Pharmaceuticals
- Intermediates & Fine Chemicals
- {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Drug Efflux Pumps, Drug Transport Compounds, Drug Transport Proteins & Reagents, Johnson & Johnson, Membrane Protein Biology Tools, Modulators for MRP Transporters, Multi-Drug Resistance, Multi-Drug Resistance and Drug Metabolism, Proteins and Derivatives, T
产品应用
- Anti-inflammatory.
相关文献及参考
- Carson, et al.: J. Med. Chem., 14, 646 (1971),
- Wong, S., et al.: J. Pharmacol. Exp. Ther., 185, 127 (1973),
- Brogden, R.N., et al.: Drugs, 15, 429 (1978),
安全信息
GHS Symbol
- H315 Causes skin irritation 会刺激皮肤
- H302 Harmful if swallowed 吞食有害
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- R38 Irritating to skin 刺激皮肤
- R22 Harmful if swallowed 吞咽有害
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >724 mg/kg TOXIC EFFECTS : Gastrointestinal - ulceration or bleeding from stomach Blood - changes in spleen REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 11,1099,1977
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >622 mg/kg TOXIC EFFECTS : Gastrointestinal - ulceration or bleeding from large intestine Blood - changes in spleen REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 11,1099,1977
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 550 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : EPXXDW European Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #134763
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1050 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Gastrointestinal - hypermotility, diarrhea REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE : 163 mg/kg SEX/DURATION : female 6-18 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 8,158,1977
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE : 1300 mg/kg SEX/DURATION : female 6-18 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - abortion REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 8,158,1977
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