Calcium ionophore III 钙离子载体 A23187, 来源于链霉菌属

CAS 52665-69-7 MFCD00151202

化学结构图

52665-69-7
SMILES: CNC1C=CC2OC(C[C@H]3O[C@@]4(CC[C@H]3C)O[C@H]([C@H](C)C(=O)C3=CC=CN3)[C@H](C)C[C@H]4C)=NC=2C=1C(O)=O

化学属性

Mol. FormulaC29H37N3O6
Mol. Weight523.62
Melting Point182-193

别名和识别编码

Chemical NameCalcium Ionophore A23187
Synonym 钙离子载体 III
CAS Number52665-69-7
PubChem Substance ID24277964
EC Number258-084-1
Beilstein Registry Number1096801
MDL NumberMFCD00151202
Chemical Name Translation钙离子载体 A23187, 来源于链霉菌属
Wiswesser Line NotationT56 BN DOJ HM1 IVQ C1- FT6OXTJ E1 B-& BT6OXTJ C1 E1FY1&V- BT5MJ
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分类

  • {SNA} A - K, Analytical/Chromatography, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics A-F, Interferes with Cell Membrane Permeability (Ionophores),
  • {SNA} A - K, Antibacterial, Antibiotics A to Z, Antibiotics A-F, Calcium Ionophores, Calcium Signaling Research Tools, Chemical Activators and Inhibitors of ER Stress, Endoplasmic Reticulum Stress, Interferes with Cell Membrane Permeability (Ionophores), Intracellular Calcium Signaling, Mechanism of Action, Spectrum of Activity, 抗生素, 生化试剂, 细胞信号转导和神经科学, 细胞生物学
  • A - K, Antibacterial, A

相关文献及参考

  • Yamada, P., et al., Inhibitory effect of various Tunisian olive oils on chemical mediator release and cytokine production by basophilic cells. J. Neurophysiol. 116 , 279-87, (2008) 摘要
  • Bode, G., et al., Interaction between S100A8/A9 and annexin A6 is involved in the calcium-induced cell surface exposition of S100A8/A9. J. Bacteriol. 283 , 31776-84, (2008) 摘要
  • Wani, N.A., Chemical activation of in vitro matured dromedary camel (Camelus dromedarius) oocytes: optimization of protocols. Ther. Drug Monit. 69 , 591-602, (2008)
  • Henry, M.L., et al., Whole blood aggregation and coagulation in db/db and ob/ob mouse models of type 2 diabetes. Blood Coag. Fibrinolysis 19 , 124-34, (2008) 摘要
  • Heaslip, A.T., et al., TgICMAP1 is a novel microtubule binding protein in Toxoplasma gondii. PLoS Biol. 4 , e7406, (2009) 摘要
  • Wohlmuth, H., et al., Diarylheptanoid From Pleuranthodium Racemigerum With In Vitro Prostaglandin E(2) Inhibitory And Cytotoxic Activity. J. Nat. Prod. 73 , 743-6, (2010) 摘要
  • Khatir, H., et al., In Vitro And In Vivo Developmental Competence Of Dromedary (Camelus Dromedarius) Oocytes Following In Vitro Fertilization Or Parthenogenetic Activation. Anim. Reprod. Sci. 113 , 212-9, (2009) 摘要
  • Kayama, H., et al., NFATc1 Mediates Toll-like Receptor-independent Innate Immune Responses During Trypanosoma Cruzi Infection. PLoS Pathog. 5 , e1000514, (2009) 摘要
  • Heaslip, A.T., et al., TgICMAP1 Is A Novel Microtubule Binding Protein In Toxoplasma Gondii. PLoS ONE 4 , e7406, (2009) 摘要
  • MrówczyÅ„ska, L., et al., Echinophilic Proteins Stomatin, Sorcin, And Synexin Locate Outside GangliosideM1 (GM1) Patches In The Erythrocyte Membrane. Biochem. Biophys. Res. Commun. 401 , 396-400, (2010) 摘要
  • Pressman, B.C., et al.

安全信息

GHS Symbol
WGK Germany3
Hazard Codes Xi
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
RTECSDM4676000
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
Signal word
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36 Wear suitable protective clothing 穿戴适当的防护服;
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Subcu

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 9200 ug/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - ptosis
   Behavioral - muscle weakness
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   NETEEC Neurotoxicology and Teratology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.9-    1987- Volume(issue)/page/year:
   9,99,1987

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4500 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BBACAQ Biochimica et Biophysica Acta.  (Elsevier Science Pub. B.V., POB 211,
   1000 AE Amsterdam, Netherlands)  V.1-    1947- Volume(issue)/page/year:
   469,281,1977

TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >25 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TOXID9 Toxicologist.  (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
   Akron, OH 44311) V.1-    1981-  Volume(issue)/page/year: 8,123,1988

TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : >13 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TOXID9 Toxicologist.  (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
   Akron, OH 44311) V.1-    1981-  Volume(issue)/page/year: 8,123,1988

TYPE OF TEST            : LD50 - Lethal d

系列性分类


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