Debrisoquine sulfate

CAS 581-88-4 MFCD00153791

化学结构图

581-88-4
SMILES: N=C(N)N1CCc2ccccc2C1.N=C(N)N1CCc2ccccc2C1.O=S(=O)(O)O

化学属性

Mol. Formula2 C10 H13 N3 . H2 O4 S
Mol. Weight448.54
Melting Point>265°C (dec.)
Boiling Point

别名和识别编码

Chemical NameDebrisoquine sulfate
CAS Number581-88-4
Synonym 2(1H)-Isoquinolinecarboximidamide, 3,4-dihydro-, sulfate (2:1) 3,4-Dihydro-2(1H)-isoquinoline carboxamidine sulfate 3,4-Dihydro-2(1H)-isoquinolinecarboximidamide 3,4-Dihydro-2(1H)-isoquinolinecarboximidamide Debrisoquin sulfate Ro 5-33071 3,4-Dihydro-2(1H)-isoquinolinecarboximidamide Hemisulfate Debrisoquin Hemisulfate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
MDL NumberMFCD00153791
PubChem Substance ID11391
EC Number209-472-4
Chemical Name Translation
Wiswesser Line NotationT66 CNT&J CYZUM & 2WSQQ
LabNetwork Molecule IDLN01343734
InChIInChI=1S/2C10H13N3.H2O4S/c2*11-10(12)13-6-5-8-3-1-2-4-9(8)7-13;1-5(2,3)4/h2*1-4H,5-7H2,(H3,11,12);(H2,1,2,3,4)
Canonical SMILESNC(=N)N1CCc2ccccc2C1.NC(=N)N3CCc4ccccc4C3.OS(=O)(=O)O
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分类

  • Bases & Related Reagents
  • {SNA} Application Index, Bioactive Small Molecules, Biochemicals and Reagents,
  • Nucleotides
  • {SNA} Application Index, Biochemicals and Reagents, Cell Signaling Enzymes,
  • {SNA} Application Index, Cell Signaling Enzymes, Cytochrome P450, Detection and Quantitation, Drug and Xenobiotic Metabolism, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzyme Substrates, L to O, Monoamine oxidase competitive inhibitor, Multi-Drug Resistance and Drug Metabolism, Reagents, Substrates, Substrates by Enzyme, Xenobiotics and Drug Metabolism, 生化试剂, 细胞信号转导和神经科学, 细胞生物学, 酶、抑制剂和底

产品应用

  • Antihypertensive.

相关文献及参考

  • Abrams, et al.: J. New Drugs, 4, 268 (1964),
  • Medina, et al.: Biochem. Pharmacol., 18, 891 (1969),
  • Goldenthal, E.I., Toxicol. Appl. Pharmacol., 18, 185 (1971),
  • 1. Ho, J.W. and Moody, D.E. Anal. Biochem. 203 , 348, (1992) 摘要
  • 2. Clement, B., et al. Biochem. Pharmacol. 46 , 2249, (1993) 摘要
  • 3. Jacqz-Aigrain, E., et al. Biochem. Pharmacol. 41 , 1657, (1991) 摘要
  • Scarr, E., et al. Prog. Neuropsychopharmacol. Biol. Psychiatry 15 , 297, (1991) 摘要
  • Merck 14 ,2844

安全信息

RTECSNW7010000
WGK Germany3
GHS Symbol
Hazard statements
  • H302 Harmful if swallowed 吞食有害
Hazard Codes Xn
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Signal word Warning
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 31700 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CTCEA9 Current Therapeutic Research, Clinical & Experimental.  (Therapeutic
   Research Press, Inc., POB 514, Tenafly, NJ 07670)  V.1-    1959-
   Volume(issue)/page/year: 6,299,1964

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 136 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CTCEA9 Current Therapeutic Research, Clinical & Experimental.  (Therapeutic
   Research Press, Inc., POB 514, Tenafly, NJ 07670)  V.1-    1959-
   Volume(issue)/page/year: 6,299,1964

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 132 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CTCEA9 Current Therapeutic Research, Clinical & Experimental.  (Therapeutic
   Research Press, Inc., POB 514, Tenafly, NJ 07670)  V.1-    1959-
   Volume(issue)/page/year: 6,299,1964

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 235 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CTCEA9 Current Therapeutic Research, Clinical & Experimental.  (Therapeutic
   Research Press, Inc., POB 514, Tenafly, NJ 07670)  V.1-    1959-
   Volume(issue)/page/year: 6,299,1964

TYPE OF TEST            : LD50 - Lethal dose, 50 pe

Storage condition -20 -20°C -20℃

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Enzyme - Enzyme Inhibitors
  6. L to O - Enzyme Inhibitors by Enzyme
  7. Monoamine oxidase competitive inhibitor - L to O
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Substrates - Enzymes, Inhibitors, and Substrates
  5. Substrates by Enzyme - Enzyme Substrates
  6. Cytochrome P450 - Substrates by Enzyme
  1. Functional Group 官能团索引
  2. sulfuric acid

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