3-Bromo-7-Nitro-1H-Indazole 3-溴-7-硝基-1H-吲唑

CAS 74209-34-0 MFCD00159910

化学结构图

74209-34-0
SMILES: [O-][N+](=O)C1=CC=CC2C(Br)=NNC=21

化学属性

Mol. FormulaC7
Mol. Weight242
Melting Point182°

别名和识别编码

Chemical Name3-Bromo-7-Nitro-1H-Indazole
CAS Number74209-34-0
Alfabeta NameBROMONITROINDAZOLE H371-----
MDL NumberMFCD00159910
PubChem Substance ID24278258
Chemical Name Translation3-溴-7-硝基-1H-吲唑
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分类

  • Inhibitors; Nitric Oxide Reagents
  • {KO} Nitros
  • {KO} ReacBromides
  • {KO} AminesSecondaryHeteroNH
  • {SA} Application Index, B, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling Enzymes, Cell Signaling and Neuroscience, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, L to O, NOS Inhibitors, Nitric Oxide Metabolism, Nitric Oxide Synthase (iNOS), Nitric Oxide Synthase Regulators, Nitric Oxide Synthase neuronal, Nitric Oxide and Cell Stress

产品应用

  • A more potent inhibitor of rat cerebellar nitric oxide synthase than 7-nitroindazole.

相关文献及参考

  • Bland-Ward, et al.: Br. J. Pharm., 112, 351P (1994)
  • 1. Raman, C.S., et al., Crystal structure of nitric oxide synthase bound to nitro indazole reveals a novel inactivation mechanism Biochemistry 40 , 13448-13455, (2001) 摘要
  • Bland-Ward, P.A., and Moore, P.K., 7-Nitro indazole derivatives are potent inhibitors of brain, endothelium and inducible isoforms of nitric oxide synthase. Life Sci. 57 , PL131-PL135, (1995) 摘要
  • Wada, K., et al., Role of nitric oxide in traumatic brain injury in the rat. J. Neurosurg. 89 , 807-818, (1998) 摘要
  • O'Neill, M.J., et al., Neuroprotective effects of the antioxidant LY231617 and NO synthase inhibitors in global cerebral ischaemia. Brain Res. Brain Res. 760 , 170-178, (1997) 摘要
  • Stagliano, N.E., et al., The role of nitric oxide in the pathophysiology of thromboembolic stroke in the rat. Brain Res. 759 , 32-40, (1997) 摘要

安全信息

Warnings IRRITANT
GHS Symbol
Precautionary statements
  • P308+P313
  • P201 Obtain special instructions before use. 使用前获取专门指示。
Signal word Danger
Hazard statements
  • H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
Hazard Codes T
WGK Germany3
Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

药物吸收、分布、代谢与排泄(ADME)

Lipinski's Rule of 3
Y
Lipinski's Rule of 5
Y
H-bond Donors
1
H-bond Acceptors
3
Rotatable Bonds
0
LogP
2

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Enzyme - Enzyme Inhibitors
  6. L to O - Enzyme Inhibitors by Enzyme
  7. Nitric Oxide Synthase (iNOS) - L to O
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Enzyme - Enzyme Inhibitors
  6. L to O - Enzyme Inhibitors by Enzyme
  7. Nitric Oxide Synthase neuronal - L to O

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