Thrombin from human plasma

CAS 9002-04-4 MFCD00082072

化学结构图

9002-04-4
SMILES:

化学属性

Mol. Weight37000(Average)
SolubilityH2O: 1 mL/vial clear to slightly hazy, colorless solution
Appearance powder
Mol. FormulaN/A

别名和识别编码

Synonym Thrombin (MW 37kDa) {LY} Thrombin (MW 37kDa) {} {LY} Thrombin (MW 37kDa) {} {} {LY} Thrombin (MW 37kDa) {} {} {} {LY} Thrombin (MW 37kDa) {} {} {} {} {LY} Thrombin (MW 37kDa) {} {} {} {} {} {LY} Thrombin (MW 37kDa) {} {} {} {} {} {} {LY} Thrombin (MW 37kDa) {} {} {} {} {} {} {} {LY} Thrombin (MW 37kDa) {} {} {} {} {} {} {} {} {LY} Thrombin (MW 37kDa) {} {} {} {} {} {} {} {} {} {LY} Thrombin (MW 37kDa) {} {} {} {} {} {} {} {} {} {} {LY} Thrombin (MW 37kDa) {} {} {} {} {} {} {} {} {} {} {} {LY} Thrombin (MW 37kDa) {} {} {} {} {} {} {} {} {} {} {} {} {LY} Thrombin (MW 37kDa) {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Thrombin (MW 37kDa) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Thrombin (MW 37kDa) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Thrombin (MW 37kDa) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Thrombin (MW 37kDa) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Thrombin (MW 37kDa) {} {} {} {} {} {} {} {} {}
MDL NumberMFCD00082072
CAS Number9002-04-4
EC Number232-648-7
Chemical NameThrombin from human plasma
Chemical Name Translation
Merck Number9346
Canonical SMILES[Thrombin]
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分类

  • 3.4.x.x Peptidases, 3.x.x.x Hydrolases, Application Index, Biochemicals and Reagents, Enzyme Class Index, Enzymes, Inhibitors, and Substrates, Proteases, Proteases & Protein Sequencing, Proteases for Recombinant Protein Fusion Tag Cleavage, Proteolytic Enzymes, Proteolytic Enzymes and Substrates, Selective Proteolytic Enzymes, Serum Proteins and Related Enzymes, Serum Related Enzymes, Thrombin
  • {SNA} 3.4.x.x Peptidases, 3.x.x.x Hydrolases, Analytical and Industrial Enzymes, Application Index, Biochemicals and Reagents, Coagulation Proteins and Reagents, Coagulation/Hematological, Core Bioreagents,
  • {SNA} 3.4.x.x Peptidases,

相关文献及参考

  • [2]. Krenzlin H, et al. The Importance of Thrombin in Cerebral Injury and Disease. Int J Mol Sci. 2016 Jan 11;17(1).
  • Merck 14 ,9383
  • [1]. Golderman V, et al. Thrombin and the Protease-Activated Receptor-1 in Organophosphate-Induced Status Epilepticus. J Mol Neurosci. 2018 Dec 4.
  • [1]. Golderman V, et al. Thrombin and the Protease-Activated Receptor-1 in Organophosphate-Induced Status Epilepticus. J Mol Neurosci. 2018 Dec 4.
  • [2]. Krenzlin H, et al. The Importance of Thrombin in Cerebral Injury and Disease. Int J Mol Sci. 2016 Jan 11;17(1).

安全信息

GHS Symbol
WGK Germany2
Precautionary statements
  • P342+P311
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
Signal word
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Hazard Codes Xn,Xi Xn,B Xn
RTECSXO8950000
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S24 Avoid contact with skin 避免皮肤接触；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R42 May cause sensitisation by inhalation 吸入会产生过敏反应
Storage condition 2-8°C, protect from light {LY} 2-8°C, protect from light {} {LY} 2-8°C, protect from light {} {} {LY} 2-8°C, protect from light {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >3 gm/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - dyspnea
   Skin and Appendages - hair
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 1,272,1973

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >50 mL/kg
TOXIC EFFECTS :
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 28,329,1984

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 7771 ug/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Lungs, Thorax, or Respiration - other changes
   Kidney, Ureter, Bladder - other changes
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 16,669,1988

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >50 mL/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yak

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Bird - chicken Embryo
DOSE/DURATION           : 10 mg/L
REFERENCE :
   PNASA6 Proceedings of the National Academy of Sciences of the United States
   of America.  (National Academy of Sciences, Printing & Pub. Office, 2101
   Constitution Ave., Washington, DC 20418) V.1-    1915-
   Volume(issue)/page/year: 72,131,1975

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - mouse Fibroblast
DOSE/DURATION           : 5 mg/L
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 13,1,1992

其他信息

  • 色指数:52000
  • 可燃性危险特性:可燃;燃烧产生有毒氮氧化物,硫氧化物和氯化氢烟雾
  • 储运特性:库房通风低温干燥
  • 急性毒性:腹腔-大鼠LD50: 215 毫克/公斤; 腹腔-小鼠LD50: 400 毫克/公斤
  • 毒性分级:高毒
  • color:white
  • 下游产品:光致变色聚噻嗪
  • 灭火剂:干粉、泡沫、砂土、二氧化碳, 雾状水
  • MOL 文件:581-64-6.mol
  • 图谱信息:劳氏紫 (581-64-6)红外图谱(IR1) 劳氏紫 (581-64-6)红外图谱(IR2) 劳氏紫 (581-64-6)质谱(MS)
  • 类别:有毒物品

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Analytical Enzymes - Enzymes, Inhibitors, and Substrates
  5. Thrombins - Analytical Enzymes
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Proteolytic Enzymes and Substrates - Enzymes, Inhibitors, and Substrates
  5. Proteolytic Enzymes - Proteolytic Enzymes and Substrates
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Immune Cell Signaling and Blood - Cell Signaling and Neuroscience
  5. Blood - Immune Cell Signaling and Blood
  6. Clotting Factors - Blood
  1. Life Science 生命科学
  2. Proteomics 蛋白质组学
  3. Recombinant Protein Expression and Analysis - Proteomics
  4. Purification and Detection - Recombinant Protein Expression and Analysis
  5. Fusion Tag and Protease Removal - Purification and Detection
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Application Index - Enzymes, Inhibitors, and Substrates
  5. Proteases & Protein Sequencing - Application Index
  6. Proteases for Recombinant Protein Fusion Tag Cleavage - Proteases & Protein Sequencing
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Proteins and Derivatives - Biochemicals and Reagents
  4. Plasma & Blood Proteins - Proteins and Derivatives
  5. Plasma, Blood, and Related Proteins and Reagents - Plasma & Blood Proteins
  6. Thrombin - Plasma, Blood, and Related Proteins and Reagents
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Proteolytic Enzymes and Substrates - Enzymes, Inhibitors, and Substrates
  5. Selective Proteolytic Enzymes - Proteolytic Enzymes and Substrates
  6. Thrombin - Selective Proteolytic Enzymes
  1. Medical Research Areas
  2. Metabolism
  3. Thrombin  (凝血酶)

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