2-Azaspiro[4.5]decan-3-one 4,4-五亚甲基-2-吡咯烷酮

CAS 64744-50-9 MFCD00177938

化学结构图

64744-50-9
SMILES: O=C1CC2(CC(=O)N1)CCCCC2

化学属性

Mol. FormulaC9H15NO
Mol. Weight153
Melting Point89-93
Boiling Point181

别名和识别编码

Chemical Name2-Azaspiro[4.5]decan-3-one
CAS Number64744-50-9
Alfabeta NameAZASPIRODECANONE 2453.[]---
MDL NumberMFCD00177938
Synonym 3,3-Pentamethylene glutarimide beta,beta-pentamethylen-glutarsaeureimid 3,3'-PENTAMETHYLENE-4-BUTYROLACTAM 3,3-Pentamethylene-2-pyrrolidoinone(CAI) or 3-Azaspiro{5,5} undecane-2,4-dione 3,3-环戊烷-4-丁内酰胺 3,3-pentamethylene-2-pyrrolidoinone (CAI) 4,4-五亚甲基-2-吡咯烷酮 GABAPENTIN INTERMEDIATES
PubChem Substance ID87559450
Chemical Name Translation4,4-五亚甲基-2-吡咯烷酮
Beilstein Registry Number119500
Reaxys-RN119500
EC Number214-459-1
Wiswesser Line NotationT5MV DXTJ D-& AL6XTJ
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分类

  • Pharmaceuticals
  • {SNA} Building Blocks, C9 to C10, Chemical Synthesis, Heterocyclic Building Blocks, Pyrrolidines
  • Neurochemicals
  • {SNA} Analytical Standards, EP Standards, EP Standards G - H, Pharmacopeia & Metrological Institutes Standards, 分析/色谱
  • Intermediates & Fine Chemicals,

产品应用

  • Gabapentin Lactam reduces protein aggregates and improves motor performance in a transgenic mouse model of Huntington?s disease. It opens mitochondrial ATP-dependent potassium channels.

相关文献及参考

  • Zucker, B.,et al.: Naunyn Schmiedebergs Arch. Pharmacol., 370, 131 (2004)

安全信息

Warnings IRRITANT
WGK Germany3
RTECSCM0120000
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
GHS Symbol
Safety Statements
Precautionary statements 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 125 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 10,243,1960

其他信息

  • Sigma Aldrich:1130-32-1(sigmaaldrich)
  • MOL 文件:1130-32-1.mol
  • 用途一:用作药物加巴喷丁中间体

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Pyrrolidines 吡咯烷
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Pyrrolidines 吡咯烷
  5. C11 to C30+ - Pyrrolidines

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