Olomoucine is a CDK inhibitor that competes for the ATP binding site of the kinase. Olomoucine was shown to reversibly arrest differentiated Petunia cells induced to divide at G1 phase and cycling Arabidopsis cells in late G1 and G2. 2-(2'-羟基乙基氨基)-9-甲基-6-(苄基氨基)嘌呤

CAS 101622-51-9 MFCD00189360

化学结构图

101622-51-9
SMILES: Cn1cnc2c(NCc3ccccc3)nc(NCCO)nc21

化学属性

Mol. FormulaC15H18N6O
Mol. Weight298.34
Appearance Solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical NameOlomoucine is a CDK inhibitor that competes for the ATP binding site of the kinase. Olomoucine was shown to reversibly arrest differentiated Petunia cells induced to divide at G1 phase and cycling Arabidopsis cells in late G1 and G2.
CAS Number101622-51-9
Synonym 2-(Hydroxyethylamino)-6-benzylamino-9-methylpurine 6-(Benzylamino)-2-(2-hydroxyethylamino)-9-methylpurine N2-[(2-Hydroxyethyl)-N6-benzyladenine NSC 666096 Olomoucine
MDL NumberMFCD00189360
PubChem Substance ID24278053
Chemical Name Translation2-(2'-羟基乙基氨基)-9-甲基-6-(苄基氨基)嘌呤
FormulaC15H18N6O
IUPAC Name6-(Benzylamino)-2-(2-hydroxyethylamino)-9-methylpurine
InChIKeyGTVPOLSIJWJJNY-UHFFFAOYSA-N
InChIInChI=1S/C15H18N6O/c1-21-10-18-12-13(17-9-11-5-3-2-4-6-11)19-15(16-7-8-22)20-14(12)21/h2-6,10,22H,7-9H2,1H3,(H2,16,17,19,20)
Canonical SMILESCN1C=NC2=C(NCC3=CC=CC=C3)N=C(NCCO)N=C12
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分类

  • Bases & Related Reagents
  • {SNA} A to C, Apoptosis and Cell Cycle, Bioactive Small Molecule Alphabetical Index, Cell Cycle Proteins, Antibodies and Reagents, Cell Cycle Regulators, Cyclin Dependent Kinases, Cyclin-Dependent Kinase (CDK), Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Kinase/Phosphatase Biology, O,

产品应用

  • Olomoucine is a CDK inhibitor that competes for the ATP binding site of the kinase. Olomoucine was shown to reversibly arrest differentiated Petunia cells induced to divide at G1 phase and cycling Arabidopsis cells in late G1 and G2.

相关文献及参考

  • Vesely, J., et a.: Eur. J. Biochem., 224, 771 (1994),
  • Vesely, J., et al., Inhibition of cyclin-dependent kinases by purine analogues. Eur. J. Biochem. 224 , 771-786, (1994) 摘要
  • Abraham, R.T., et al., Cellular effects of olomoucine, an inhibitor of cyclin-dependent kinases. Biol. Cell 83 , 105-120, (1995) 摘要

安全信息

WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类


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