Olomoucine is a CDK inhibitor that competes for the ATP binding site of the kinase. Olomoucine was shown to reversibly arrest differentiated Petunia cells induced to divide at G1 phase and cycling Arabidopsis cells in late G1 and G2. 2-(2'-羟基乙基氨基)-9-甲基-6-(苄基氨基)嘌呤
CAS 101622-51-9 MFCD00189360
化学结构图
SMILES: Cn1cnc2c(NCc3ccccc3)nc(NCCO)nc21
化学属性
Mol. Formula
C15H18N6O
Mol. Weight
298.34
Appearance
Solid powder
Solubility
Soluble in DMSO, not in water
别名和识别编码
Chemical Name
Olomoucine is a CDK inhibitor that competes for the ATP binding site of the kinase. Olomoucine was shown to reversibly arrest differentiated Petunia cells induced to divide at G1 phase and cycling Arabidopsis cells in late G1 and G2.
{SNA} A to C, Apoptosis and Cell Cycle, Bioactive Small Molecule Alphabetical Index, Cell Cycle Proteins, Antibodies and Reagents, Cell Cycle Regulators, Cyclin Dependent Kinases, Cyclin-Dependent Kinase (CDK), Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Kinase/Phosphatase Biology, O,
产品应用
Olomoucine is a CDK inhibitor that competes for the ATP binding site of the kinase. Olomoucine was shown to reversibly arrest differentiated Petunia cells induced to divide at G1 phase and cycling Arabidopsis cells in late G1 and G2.
相关文献及参考
Vesely, J., et a.: Eur. J. Biochem., 224, 771 (1994),
Vesely, J., et al., Inhibition of cyclin-dependent kinases by purine analogues. Eur. J. Biochem. 224 , 771-786, (1994) 摘要
Abraham, R.T., et al., Cellular effects of olomoucine, an inhibitor of cyclin-dependent kinases. Biol. Cell 83 , 105-120, (1995) 摘要
安全信息
WGK Germany
3
Personal Protective Equipment
Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Storage condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).