L-Chicoric Acid L-菊苣酸

CAS 70831-56-0 MFCD00189418

化学结构图

70831-56-0
SMILES: OC(=O)[C@H](OC(=O)/C=C/c1cc(O)c(O)cc1)[C@@H](OC(=O)/C=C/c1cc(O)c(O)cc1)C(O)=O

化学属性

Mol. FormulaC22H18O12
Mol. Weight474.37
Melting Point206

别名和识别编码

Chemical NameL-Chicoric Acid
CAS Number6537-80-0
Synonym (2R,3R)-2,3-Bis{[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy}butanedioic acid, 2,3-Di-trans-caffeoyltartaric acid
Chemical Name TranslationL-菊苣酸
InChIKeyYDDGKXBLOXEEMN-IABMMNSOSA-N
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分类

  • {SNA} Cell Biology, Cichorium intybus (Chicory), Nutrition Research, Phytochemicals by Plant (Food/Spice/Herb)
  • {SNA} Cichorium intybus (Chicory), Phytochemicals by Plant (Food/Spice/Herb), 细胞生物学, 营养研究

相关文献及参考

  • [2]. King PJ, et al. Resistance to the anti-human immunodeficiency virus type 1 compound L-chicoric acid results from a single mutation at amino acid 140 of integrase. J Virol. 1998 Oct;72(10):8420-4.
  • [3]. Robinson WE Jr. L-chicoric acid, an inhibitor of human immunodeficiency virus type 1 (HIV-1) integrase, improves on the in vitro anti-HIV-1 effect of a protease inhibitor (AG1350). Antiviral Res. 1998 Aug;39(2):101-11.
  • [1]. Reinke RA, et al. L-chicoric acid inhibits human immunodeficiency virus type 1 integration in vivo and is a noncompetitive but reversible inhibitor of HIV-1 integrase in vitro. Virology. 2004 Sep 1;326(2):203-19.
  • [1]. Reinke RA, et al. L-chicoric acid inhibits human immunodeficiency virus type 1 integration in vivo and is a noncompetitive but reversible inhibitor of HIV-1 integrase in vitro. Virology. 2004 Sep 1;326(2):203-19.
  • [2]. King PJ, et al. Resistance to the anti-human immunodeficiency virus type 1 compound L-chico

安全信息

Hazard Codes Xn
GHS Symbol
WGK Germany3
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P342+P311
Hazard statements
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H302 Harmful if swallowed 吞食有害
  • H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难
Signal word Danger
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
  • R42/43

系列性分类

  1. Functional Group 官能团索引
  2. 1,2-diphenol
  1. Medical Research Areas
  2. Metabolism
  3. HIV Integrase  (HIV整合酶)

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