CONCANAMYCIN A 伴刀球霉素A

CAS 80890-47-7 MFCD00210037

化学结构图

80890-47-7
SMILES: C/C=C/[C@H]1O[C@@](O)(C[C@@H](O[C@H]2C[C@@H](O)[C@H](OC(N)=O)[C@@H](C)O2)[C@@H]1C)C(C)C(O)C(C)C1OC(=O)C(=CC(C)=CC(C)C(O)C(CC)C(O)C(C)CC(C)=CC=CC1OC)OC |t:36,39,54,56|

化学属性

Mol. FormulaC46H75NO14
Mol. Weight866.09

别名和识别编码

Chemical NameConcanamycin A
Synonym Folimycin X 4357 B Concanamycin A
MDL NumberMFCD00210037
PubChem Substance ID24893186
Beilstein Registry Number3560277
CAS Number80890-47-7
Chemical Name Translation伴刀球霉素A
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分类

  • {SNA} Antibiotics A to Z, Antibiotics A-F, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics, Antiviral, Bioactive Small Molecule Alphabetical Index, CI-CZ, Chemical Structure Class, Inhibitors, Inhibitors and Substrates, Inhibits an Enzyme, Ion Channels, Ion Pump Inhibitors, Macrolides, Mechanism of Action, Monovalent Ion Channels, Spectrum of Activity, Voltage-gated Ion Channels, 分子生物学, 抗生素, 生化试剂, 生物活性小分子, 糖生物学, 细胞信号转导和神经科学, 细胞生物学,

相关文献及参考

  • Nishihara, T., et al. Biochem. Biophys. Res. Commun. 212 , 255, (1995) 摘要
  • Drose, S., et al. Biochemistry 32 , 3902, (1993) 摘要
  • Beil. 25 ,IV,3676

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P301+P310
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P302+P350
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P305+P351+P338
Hazard statements
  • H330 Fatal if inhaled 吸入致命
  • H310 Fatal in contact with skin 皮肤接触致命
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H300 Fatal if swallowed 吞食致命
Hazard Codes T+
RTECSCB9732000
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Signal word Danger
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
Risk Statements
  • R26/27/28 Very toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有剧毒
  • R36 Irritating to eyes 刺激眼睛
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 21 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #4076802

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2450 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #4076802

系列性分类

  1. Life Science 生命科学
  2. Antibiotics 抗生素
  3. Antibiotics A to Z - Antibiotics
  4. Antibiotics A-F - Antibiotics A to Z
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Ion Channels - Cell Signaling and Neuroscience
  5. Voltage-gated Ion Channels - Ion Channels
  6. Monovalent Ion Channels - Voltage-gated Ion Channels
  7. Ion Pump Inhibitors - Monovalent Ion Channels
  1. Functional Group 官能团索引
  2. enol ether
  1. Functional Group 官能团索引
  2. hemiacetal

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