(1R,3r,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl 1H-indole-3-carboxylate hydrochloride 盐酸托烷司琼
CAS 105826-92-4 MFCD00210221
化学结构图
SMILES: CN1[C@@H]2C[C@H](C[C@H]1CC2)OC(=O)C1=CNC2C=CC=CC=21 |&1:2,4,6|
化学属性
| Mol. Formula | C17H20N2O2·HCl |
|---|---|
| Mol. Weight | 320.82 |
| TSCA | No |
别名和识别编码
| Chemical Name | (1R,3r,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl 1H-indole-3-carboxylate hydrochloride |
|---|---|
| Synonym | Tropisetron Tropisetron hydrochloride 3-Tropanylindole-3-carboxylate monohydrochloride ICS-205,930 Navoban endo-8-Methyl-8-azabicyclo[3.2.1]oct-3-ol Indol-3-yl-carboxylate 单盐酸盐 |
| MDL Number | MFCD00210221 |
| PubChem Substance ID | 160871173 |
| CAS Number | 105826-92-4 |
| Merck Number | 9783 |
| Chemical Name Translation | 盐酸托烷司琼 |
| Reaxys-RN | 8883131 |
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分类
- {SNA} Antagonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Diversification Ready Pharma-Developed Compounds, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Protein Biology Tools, Neuroscience, Neurotransmission, Neurotransmitters, Novartis, Serotonergics, Serotonergics - Antagonists, T, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学, 蛋白质及衍生物
- {SNA} Antagonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neur
相关文献及参考
- [2]. Swartz MM, et al. Tropisetron as a neuroprotective agent against glutamate-induced excitotoxicity and mechanisms of action. Neuropharmacology. 2013 Oct;73:111-21.
- [3]. Aminian A, et al. Tropisetron diminishes demyelination and disease severity in an animal model of multiple sclerosis. Neuroscience. 2013 Jun 15;248C:299-306.
- [4]. Rahimian R, et al. Tropisetron upregulates cannabinoid CB1 receptors in cerebellar granule cells: possible involvement of calcineurin. Brain Res. 2011 Oct 12;1417:1-8.
- [1]. Rahimian R, et al. Tropisetron attenuates amyloid-beta-induced inflammatory and apoptotic responses in rats. Eur J Clin Invest. 2013 Oct;43(10):1039-51.
- [1]. Rahimian R, et al. Tropisetron attenuates amyloid-beta-induced inflammatory and apoptotic responses in rats. Eur J Clin Invest. 2013 Oct;43(10):1039-51.
- [2]. Swartz MM, et al. Tropisetron as a neuroprotective agent against glutamate-induced excitotoxicity and mechanisms of action
安全信息
- H301 Toxic if swallowed 吞食有毒
GHS Symbol
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P301+P310+P330
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
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