10-(3-(4-Hydroxypiperidin-1-yl)propyl)-10H-phenothiazine-2-carbonitrile , Pericyazine 10-(3-(4-羟基哌啶-1-基)丙基)-10H-吩噻嗪-2-甲腈
CAS 2622-26-6 MFCD00210348
化学结构图
SMILES: N#Cc1ccc2c(c1)N(CCCN1CCC(O)CC1)c1ccccc1S2
化学属性
| Mol. Formula | C21H23N3OS |
|---|---|
| Mol. Weight | 365 |
别名和识别编码
| Chemical Name | 10-(3-(4-Hydroxypiperidin-1-yl)propyl)-10H-phenothiazine-2-carbonitrile , Pericyazine |
|---|---|
| CAS Number | 2622-26-6 |
| Synonym | 2-Cyano-10-(3-(4-hydroxypiperidino)propyl)phenothiazine Cyano-3 ((hydroxy-4 piperidyl-1)-3 propyl)-10 phenothiazine SKF 20,716 Bayer 1409 2-Cyano-10-(3-(4-hydroxy-1-piperidyl)propyl)phenothiazine 10-(3-(4-Hydroxypiperidino)propyl)phenothiazine-2-carbonitrile Nemactil Neulactil Periciazine Aolept WH 7508 Neuleptil F.I. 6145 Piperocyanomazine 6909 RP ######## 4-Piperidinol, 1-(3-(2-cyano-10-phenothiazinyl)propyl)- RP 8908 Pericyazine Propericiazine IC 6002 |
| Chemical Name Translation | 10-(3-(4-羟基哌啶-1-基)丙基)-10H-吩噻嗪-2-甲腈 |
| Wiswesser Line Notation | T C666 BN ISJ ECN B3- AT6NTJ DQ |
| Beilstein Registry Number | 0576739 |
| MDL Number |
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分类
- Amines
- Aromatics
- Heterocycles
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Sulfur & Selenium Compounds
产品应用
- Psychotherapeutic phenothiazine. Antipsychotic.
相关文献及参考
- [2]. Farde L, et al. D1- and D2-dopamine receptor occupancy during treatment with conventional and atypicalneuroleptics. Psychopharmacology (Berl). 1989;99 Suppl:S28-31.
- [3]. Divac N, et al. Second-generation antipsychotics and extrapyramidal adverse effects. Biomed Res Int. 2014;2014:656370.
- [4]. Cai HL, et al. A sensitive LC-MS/MS method for analysis of pericyazine in presence of 7-hydroxypericyazine and pericyazine sulphoxide in human plasma and its application to a comparative bioequivalence study in Chinese healthy volunteers. J Pharm Biomed Anal. 2017;135:67‐74.
- Kaye, J., et al.: Br. J. Clin. Pharmacol., 56, 569 (2003),
- Schafer, et al.: Toxicol. Appl. Pharmacol., 21, 315 (1972),
- Tschoner, A., et al.: Pharmacopsychiatry, 42, 29 (2009),
- [1]. Morley KC, et
- [1]. Morley KC, et al. Pericyazine in the treatment of cannabis dependence in general practice: a naturalistic pilot trial. Subst Abuse Rehabil. 2012 May 28;3:43-7.
安全信息
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 530 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849- Volume(issue)/page/year: 157,1242,1963
{TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,43,1972
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 85 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,43,1972
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Bird - wild bird species DOSE/DURATION : 100 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 21,315,1972
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION
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