α-Amanitin Α-毒伞肽

CAS 23109-05-9 MFCD00215842

化学结构图

23109-05-9
SMILES: CCC(C)[C@@H]1NC(=O)CNC(=O)[C@H]2CC3C4C=CC(O)=CC=4NC=3S(=O)C[C@@H](NC(=O)CNC1=O)C(=O)N[C@H](CC(N)=O)C(=O)N1CC(C(O)C1)C(=O)N[C@@H]([C@@H](C)[C@@H](O)CO)C(=O)N2

化学属性

Mol. FormulaC39
Mol. Weight919
Melting Point254-255 °C(lit.)

别名和识别编码

Chemical Namealpha-Amanitine
PubChem Substance ID24890639
EC Number245-432-2
Beilstein Registry Number1071138
MDL NumberMFCD00215842
Synonym alpha-Amatoxin α-Amanitin alpha-Amanitin
Chemical Name TranslationΑ-毒伞肽
CAS Number23109-05-9
Wiswesser Line NotationT C6 B5 R5-18--18-/MP& A K L 2BJ P& IM KS NVM QVN WVMC&VM F&VM I&VM L&VM O&VM&&TTTJ FQ KO P1
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分类

  • {SNA} A-AM, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, DNA-RNA Transcription Regulators, Gene Regulation and Expression, Mushroom, Toxins and Venoms
  • {SNA} DNA-RNA Transcription Regulators, Gene Regulation and Expression, Mushroom, Toxins and Venoms, 细胞信号转导和神经科学, 细胞生物学

安全信息

GHS Symbol
WGK Germany3
Hazard statements
  • H330 Fatal if inhaled 吸入致命
  • H310 Fatal in contact with skin 皮肤接触致命
  • H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
  • H300 Fatal if swallowed 吞食致命
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
RTECSBD6195000
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P301+P310
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P302+P350
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
Signal word Danger
Hazard Codes T+
Risk Statements
  • R33 Danger of cumulative effects 有累积作用的危险
  • R26/27/28 Very toxic by inhalation, in contact with skin and if swallowed 吸入,皮肤接触及吞食都有剧毒
Safety Statements
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 100 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NEJMAG New England Journal of Medicine.  (Massachusetts Medical Soc., 10
   Shattuck St., Boston, MA 02115)  V.198-    1928-  Volume(issue)/page/year:
   269,223,1963

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 300 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 22,2142,1972

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 100 nmol/L
REFERENCE :
   TOXIA6 Toxicon.  (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW,
   UK)  V.1-    1962-  Volume(issue)/page/year: 25,1265,1987

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Int

TYPE OF TEST            : Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 1 mg/kg
REFERENCE :
   BBACAQ Biochimica et Biophysica Acta.  (Elsevier Science Pub. B.V., POB 211,
   1000 AE Amsterdam, Netherlands)  V.1-    1947- Volume(issue)/page/year:
   782,262,1984

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Insect - Drosophila melanogaster Cells - not
                          otherwise specified
DOSE/DURATION           : 20 mg/L
REFERENCE :
   IJEBA6 Indian Journal of Experimental Biology.  (Publications & Information
   Directorate, CSIR, Hillside Rd., New Delhi 110 012, India)  V.1-    1963-
   Volume(issue)/page/year:

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 125 mg/L
REFERENCE :
   AMICCW Archives of Microbiology.  (Springer-Verlag New York, Inc., Service
   Center, 44 Hartz Way, Secacus, NJ 07094)  V.95-    1974-
   Volume(issue)/page/year: 118,317,1978

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Insect - not otherwise specified Cells - not
                          otherwise specified
DOSE/DURATION           : 10 ug
REFERENCE :
   BBACAQ Biochimica et Biophysica Acta.  (Elsevier Science Pub. B.V., POB 211,
   1000 AE Amsterdam, Netherlands)  V.1-    1947- Volume(issue)/page/year:
   697,213,1982

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