Oxaprozin 奥沙普嗪
CAS 21256-18-8 MFCD00215977
化学结构图
SMILES: OC(=O)CCC1=NC(=C(O1)C1C=CC=CC=1)C1C=CC=CC=1
化学属性
| Mol. Formula | C18H15NO3 |
|---|---|
| Mol. Weight | 293 |
| Melting Point | 161-165 |
别名和识别编码
| Chemical Name | Oxaprozin |
|---|---|
| CAS Number | 21256-18-8 |
| Synonym | Wy 21743 4,5-Diphenyl-2-oxazolepropanoic Acid 4,5-Diphenyl-2-oxazolepropionic acid WY-21743 2-Oxazolepropanoic acid, 4,5-diphenyl- NSC 310839 Oxapro Daypro 4,5-Diphenyl-2-oxazolepropanoic acid; 3-(4,5-Diphenyl-1,3-oxazol-2-yl)propanoic acid Duraprost Alvo Durapro 4,5-Diphenyl-2-oxazolepropanoic acid 3-(4,5-Diphenyloxazol-2-yl)propionic Acid 4,5-Diphenyl-2-oxazolepropanoic acid ?-(4,5-D 4,5-Diphenyl-2-oxazolepropionic Acid |
| MDL Number | MFCD00215977 |
| PubChem Substance ID | 160871033 |
| EC Number | 244-296-1 |
| Alfabeta Name | DIPHENYLOXAZOLYLPROPANOICACID 345132()------,, |
| Chemical Name Translation | 奥沙普嗪 |
| Reaxys-RN | 1083168 |
| Merck Number | 6924 |
| Beilstein Registry Number | 1083168 |
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分类
- {SNA} A to C, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Cyclooxygenase, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Immune Cell Signaling and Blood, Immune System Regulation,
- {
- Heterocycles
- Pharmaceuticals
- Intermediates & Fine Chemicals
- {SNA} A to C, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Cyclooxygenase, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Immune Cell Signaling and Blood, Immune System Regulation, Immunomodulators and Antibiotics, O, Pfizer Compounds
- Aromatics
产品应用
- Oxaprozin is an anti-inflammatory drug. Oxaprozin was comparable to Aspirin (A687780).
相关文献及参考
- Whitehouse, M.W., et al.: Biochem. Pharmacol., 20, 2309 (1971),
- Janssen, F.W., et al.: Drug Metab. Dispos., 6, 465 (1978),
- Shriver, D.A., et al.: Toxicol. Appl. Pharmacol., 42, 75 (1977),
安全信息
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
- S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
- R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
- P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
- H303 May be harmfully swallowed 吞食可能有害
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 124 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory depression Gastrointestinal - other changes REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 15,359,1984
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : >1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dos
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 376 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory depression Gastrointestinal - other changes REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 15,359,1984
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 36 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory depression Gastrointestinal - other changes REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 15,359,1984
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TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 10 mg/kg SEX/DURATION : female 21 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - other effects to embryo REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 18,528,1984
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE : 520 mg/kg SEX/DURATION : female 6-18 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 15,250,1984
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 220 mg/kg SEX/DURATION : female 7-17 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system Reproductive - Specific Developmental Abnormalities - blood and lymphatic systems (including spleen and marrow) REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 15,225,1984
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE :
GHS Symbol
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