Latanoprost 拉坦前列腺素
CAS 130209-82-4 MFCD00216074
化学结构图
SMILES: CC(C)OC(=O)CCC/C=C\C[C@@H]1[C@H](O)C[C@H](O)[C@H]1CC[C@H](O)CCC1=CC=CC=C1 |&1:12,13,16,18,21|
化学属性
| Mol. Formula | C26H40O5 |
|---|---|
| Mol. Weight | 433 |
别名和识别编码
| Chemical Name | Latanoprost |
|---|---|
| CAS Number | 130209-82-4 |
| Synonym | ######## Isopropyl (5Z,9α,11α,15R)-9,11,15-trihydroxy-17-phenyl-18,19,20-trinor-prost-5-en-1-oate Isopropyl (5Z,9α,11α,15R)-9,11,15-trihydroxy-17-phenyl-18,19,20-trinor-prost-5-en-1-oate Isopropyl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoate Xalatan Isopropyl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoate Latanoprost Xalatan |
| MDL Number | MFCD00216074 |
| PubChem Substance ID | 253662165 |
| Chemical Name Translation | 拉坦前列腺素 |
| Reaxys-RN | 5912370 |
| Merck Number | 5376 |
| LabNetwork Molecule ID | LN01304761 |
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分类
- {SNA} Approved Therapeutics/Drug Candidates, Arachidonic Acid Cascade, Bioactive Small Molecule Alphabetical Index, Fluorination Ready Pharma-Developed Compounds, Johnson & Johnson, L, Lipids in Cell Signaling, Prostaglandins, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
- Chiral Reagents
- Pharmaceuticals
- Intermediates & Fine Chemicals
- {SNA} Approved Therapeutics/Drug Candidates, Arachidonic Acid Cascade, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Johnson & Johnson, L, Lipids in Cell Signaling, Prostaglandins
- Aromatics
产品应用
- Prostaglandin analog, used to treat glaucoma and other degenerative diseases of the eye.
相关文献及参考
- [2]. Zheng J, et al. Latanoprost promotes neurite outgrowth in differentiated RGC-5 cells via the PI3K-Akt-mTOR signaling pathway. Cell Mol Neurobiol. 2011 May;31(4):597-604.
- [3]. Tsai S, et al. The effect of topical latanoprost on anterior segment anatomic relationships in normal dogs. Vet Ophthalmol. 2013 Sep;16(5):370-6.
- [4]. Ooi YH, et al. Effect of bimatoprost, latanoprost, and unoprostone on matrix metalloproteinases and their inhibitors in human ciliary body smooth muscle cells. Invest Ophthalmol Vis Sci. 2009 Nov;50(11):5259-65.
- [5]. B'Ann True Gabelt, et al. Prostaglandin Subtype-Selective and Non-Selective IOP-Lowering Comparison in Monkeys.
- Hernandez, M., et al.: Exp. Eye Res., 86, 798 (2008),
- Nagata, T., et al.: J. Pharmacol. Sci., 106, 423 (2008),
- Rhee, D.J., et al.: Clinic. Ophthalmol., 2, 313 (2008),
- [1]. Pauly A, et al. In vitro and in vivo comparative toxicological study of a new preservative-free latan
安全信息
GHS Symbol
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P301+P310
- H300 Fatal if swallowed 吞食致命
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