GF 109203X 3-[1-[3-(二甲氨基)丙基]1H-吲哚-3-基]-4-(吲哚-3-基)1H-吡咯-2,5二酮
CAS 133052-90-1 MFCD00236428
化学结构图
SMILES: CN(C)CCCN1C=C(C2=C(C3=CNC4C=CC=CC=43)C(=O)NC2=O)C2C=CC=CC1=2
化学属性
| Mol. Formula | C25H24N4O2 |
|---|---|
| Mol. Weight | 412 |
别名和识别编码
| Chemical Name | GF 109203X |
|---|---|
| Synonym | 3-(N-[Dimethylamino]propyl-3-indolyl)-4-(3-indolyl)maleimide 3-[1-[3-(Dimethylamino)propyl]1H-indol-3-yl]-4-(1Hindol-3-yl)1H-pyrrole-2,5dione Bisindolylmaleimide I GF 109203X GF109203X; GF-109203X; GF 109203X; bisindolylmaleimide; GO 6850; GO-6850; GO6850. BIMI. |
| MDL Number | MFCD00236428 |
| Chemical Name Translation | 3-[1-[3-(二甲氨基)丙基]1H-吲哚-3-基]-4-(吲哚-3-基)1H-吡咯-2,5二酮 |
| PubChem Substance ID | 329799908 |
| Formula | C25H24N4O2 |
| IUPAC Name | 3-(1-(3-(dimethylamino)propyl)-1H-indol-3-yl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione |
| InChIKey | QMGUOJYZJKLOLH-UHFFFAOYSA-N |
| InChI | InChI=1S/C25H24N4O2/c1-28(2)12-7-13-29-15-19(17-9-4-6-11-21(17)29)23-22(24(30)27-25(23)31)18-14-26-20-10-5-3-8-16(18)20/h3-6,8-11,14-15,26H,7,12-13H2,1-2H3,(H,27,30,31) |
| Canonical SMILES | O=C(C(C1=CN(CCCN(C)C)C2=C1C=CC=C2)=C3C4=CNC5=C4C=CC=C5)NC3=O. |
| CAS Number | 133052-90-1 |
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分类
- {SNA} Autophagy, Autophagy Activators, Cell Biology, Cell Signaling and Neuroscience, Kinase/Phosphatase Biology, Protein Kinase Inhibitors
- {SNA} Autophagy, Autophagy Activators, Kinase/Phosphatase Biology, Protein Kinase Inhibitors, 细胞信号转导和神经科学, 细胞生物学
产品应用
- GF-109203X is a potent and highly selective PCK inhibitor, which inhibits PKC isozymes alpha, beta 1, beta 2, gamma, delta and epsilon in vitro . GF-109203X inhibited GSK-3 in vitro, when assayed either in cell lysates (IC(50) 360 nM or in GSK-3beta immunoprecipitates (IC(50) 170 nM derived from rat epididymal adipocytes. Pretreatment of adipocytes with GF-109203X (5 microM) reduced GSK-3 activity in total cell lysates, to 25.1+/-4.3% of control.
安全信息
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
- R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
- R22 Harmful if swallowed 吞咽有害
GHS Symbol
- P281 Use personal protective equipment as required. 使用所需的个人防护装备。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- H351 Suspected of causing cancer 怀疑致癌
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