Buflomedil Hydrochloride 4-(1-吡咯烷基)-1-(2,4,6-三甲氧基苯基)-1-丁酮盐酸盐

CAS 35543-24-9 MFCD35543249

化学结构图

35543-24-9
SMILES: COC1C=C(C=C(OC)C=1C(=O)CCCN1CCCC1)OC

化学属性

Mol. Weight344
Mol. FormulaC17H26ClNO4

别名和识别编码

CAS Number35543-24-9
Chemical NameBuflomedil Hydrochloride
Synonym Buflan Loftyl Irrodan R Buflonat Bufedil Provas Irrodan Fonzylane Buflocit Buflomedil hydrochloride 4-(1-Pyrrolidyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone hydrochloride 4-(1-Pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone Hydrochloride A-48257 4-(1-Pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone hydrochloride LL 1656 Chlorhydrate de (trimethoxy-2-4-6) phenyl-(pyrrolidine-3) propylacetone Lofton
Chemical Name Translation4-(1-吡咯烷基)-1-(2,4,6-三甲氧基苯基)-1-丁酮盐酸盐
MDL Number
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分类

  • Aromatics
  • Heterocyclic
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • Buflomedil is used as an vasodilator (peripheral).

相关文献及参考

  • Gundert-Remy, U., et al.: Eur. J. Clin. Pharmacol., 20, 459 (1981),
  • Rosas, G., et al.: Angiology, 32, 291 (1981),
  • Clissold, S.P., et al.: Drugs, 33, 430 (1987),

安全信息

RTECSEL9900000 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 216 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - coma
   Cardiac - other changes
REFERENCE :
   ICMED9 Intensive Care Medicine.  (Springer-Verlag New York, Inc., Service
   Center, 44 Hartz Way, Secaucus, NJ 07094)  V.3-    1977-
   Volume(issue)/page/year: 22,57,1996

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 410 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Repo

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 60 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - coma
REFERENCE :
   ICMED9 Intensive Care Medicine.  (Springer-Verlag New York, Inc., Service
   Center, 44 Hartz Way, Secaucus, NJ 07094)  V.3-    1977-
   Volume(issue)/page/year: 22,57,1996

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 55 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - coma
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
REFERENCE :
   ICMED9 Intensive Care Medicine.  (Springer-Verlag New York, Inc., Service
   Center, 44 Hartz Way, Secaucus, NJ 07094)  V.3-    1977-
   Volume(issue)/page/year: 20,219,1994

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1500 mg/kg
SEX/DURATION            : female 17-22 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - parturition
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 22,473,1988

系列性分类

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