4-Phenyl-3-furoxancarbonitrile
CAS 125520-62-9 MFCD00270898
化学结构图
SMILES: N#CC1C(=NO[N+]=1[O-])C1C=CC=CC=1
化学属性
| Mol. Formula | C9H5N3O2 |
|---|---|
| Mol. Weight | 187.15 |
别名和识别编码
| Chemical Name | 4-Phenyl-3-furoxancarbonitrile |
|---|---|
| CAS Number | 7578-25-8 |
| Synonym | Furoxan Furoxan RVC-589 Furoxan, RVC-589 Phenyl-furazancarbonitrile 2-Oxide RVC-589 |
| MDL Number | MFCD00270898 |
| PubChem Substance ID | 24278622 |
| Chemical Name Translation |
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资金保障
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分类
- {SNA} Application Index, Biochemicals and Reagents, Cell Signaling Enzymes, D to K, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzyme Substrates, Guanylate cyclase, NO Donors, Nitric Oxide Donors, Nitric Oxide Metabolism, Nitric Oxide Synthase/NO Donor,
产品应用
- Able to activate the soluble guanylate cyclase by releasing Nitric Oxide under the action of thiol cofactors. Also inhibits platelet aggregation.
相关文献及参考
- Medana, C., et al.: J. Med. Chem., 37, 4412 (1994),
- Feridi, R., et al.: Br. J. Pharm., 114, 816 (1995),
- 1. Medana, C., et al., Furoxans as nitric oxide donors: 4-phenyl-3-furoxancarbonitrile: thiol-mediated nitric oxide release and biological evaluation J. Med. Chem. 37 , 4412-4416, (1994) 摘要
- Feridi, R., et al. Br. J. Pharmacol. 114 , 816, (1995) 摘要
- Liu, S.X., et al. J. Ocul. Pharmacol. Ther. 13 , 105, (1997) 摘要
安全信息
GHS Symbol
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P305+P351+P338
- H332 Harmful if inhaled 吸入有害
- H315 Causes skin irritation 会刺激皮肤
- H302 Harmful if swallowed 吞食有害
- H312 Harmful in contact with skin 皮肤接触有害
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- H319 Causes serious eye irritation 严重刺激眼睛
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
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