5-Hexynoic acid, 4-amino-

CAS 57659-38-8 MFCD00468056

化学结构图

57659-38-8
SMILES: C#CC(N)CCC(O)=O

化学属性

Mol. FormulaC6H9NO2
Mol. Weight127.16

别名和识别编码

Chemical Name5-Hexynoic acid, 4-amino-
Synonym RMI 71645 4-Amino-5-hexynoic acid gamma-Acetylenic gaba
MDL NumberMFCD00468056
PubChem Substance ID24278145
CAS Number57659-38-8
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分类

  • {SNA} A-AM, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Enzyme Inhibitors, GABA-Transaminase, Neuroscience, Neurotransmission, Neurotransmitter Metabolism

相关文献及参考

  • Schousboe, et al., Stereoselective uptake of GABA-transaminase inhibitors γ-vinyl GABA and γ-acetylenic GABA into neurons and astrocytes. Neurochem. Res. 11 , 1497, (1986) 摘要
  • Loscher, γ-Acetylenic GABA antagonizes the decrease in synaptosomal GABA concentrations but not the seizures induced by 3-mercaptoproprionic acid in rats. Biochem. Pharmacol. 15 , 3176-3180, (1986)
  • Loscher, et al., Differential effects of vigabatrin, γ-acetylenic GABA, aminooxycetic acid, and valproate on levels of various amino acids in rat brain regions and plasma. Naunyn Schmiedebergs Arch. Pharmacol. 349 , 270-278, (1994) 摘要

安全信息

GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
Hazard Codes Xi
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
WGK Germany3
Signal word Warning
RTECSMR0180450
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 310 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - ptosis
   Behavioral - somnolence (general depressed activity)
   Skin and Appendages - hair
REFERENCE :
   NEPHBW Neuropharmacology.  (Pergamon Press Ltd., Headington Hill Hall,
   Oxford OX3 OBW, UK) V.9-    1970-  Volume(issue)/page/year: 21,803,1982

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Neuroscience - Cell Signaling and Neuroscience
  5. Neurotransmission - Neuroscience
  6. Neurotransmitter Metabolism - Neurotransmission
  7. Enzyme Inhibitors - Neurotransmitter Metabolism
  8. GABA-Transaminase - Enzyme Inhibitors

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