UA62784 is a specific inhibitor of centromere protein E (CENPE) kinesin-like protein; mitotic inhibitor. CENP-E is a kinesin-like motor protein that localizes to the kinetochore during mitosis and is essential for bipolar spindle formation. UA62784 is a novel specific inhibitor of CENP-E, which likely binds within the motor domain of CENP-E. UA62784 causes reversible cell cycle arrest in mitosis before metaphase, which leads to apoptosis. The compound is not interacting with microtubules directly.

CAS 313367-92-9 MFCD00489199

化学结构图

313367-92-9
SMILES: COc1ccc(-c2cnc(-c3cccc4c3-c3ccccc3C4=O)o2)cc1

化学属性

Mol. FormulaC23H15NO3
Mol. Weight353.37
Appearance Light yellow to yellow solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical NameUA62784 is a specific inhibitor of centromere protein E (CENPE) kinesin-like protein; mitotic inhibitor. CENP-E is a kinesin-like motor protein that localizes to the kinetochore during mitosis and is essential for bipolar spindle formation. UA62784 is a novel specific inhibitor of CENP-E, which likely binds within the motor domain of CENP-E. UA62784 causes reversible cell cycle arrest in mitosis before metaphase, which leads to apoptosis. The compound is not interacting with microtubules directly.
Synonym 4-[5-(4-Methoxyphenyl)-2-oxazolyl]-9H-Fluoren-9-one UA62784 UA62784, UA62784, UA 62784
MDL NumberMFCD00489199
PubChem Substance ID329827627
Chemical Name Translation
FormulaC23H15NO3
IUPAC Name4-(5-(4-methoxyphenyl)oxazol-2-yl)-9H-fluoren-9-one
InChIKeySVICLWPFAQYZLX-UHFFFAOYSA-N
InChIInChI=1S/C23H15NO3/c1-26-15-11-9-14(10-12-15)20-13-24-23(27-20)19-8-4-7-18-21(19)16-5-2-3-6-17(16)22(18)25/h2-13H,1H3
Canonical SMILESO=C1C2=C(C3=C1C=CC=C3)C(C4=NC=C(C5=CC=C(OC)C=C5)O4)=CC=C2
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分类

  • {SNA} Apoptosis and Cell Cycle, Cell Biology, Cell Cycle Proteins and Antibodies, Cell Cycle Regulators, Cell Signaling and Neuroscience
  • {SNA} Apoptosis and Cell Cycle, Bioactive Small Molecule Alphabetical Index, Cell Cycle Proteins, Antibodies and Reagents, Cell Cycle Regulators, U, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学

产品应用

  • UA62784 is a specific inhibitor of centromere protein E (CENPE) kinesin-like protein; mitotic inhibitor. CENP-E is a kinesin-like motor protein that localizes to the kinetochore during mitosis and is essential for bipolar spindle formation. UA62784 is a novel specific inhibitor of CENP-E, which likely binds within the motor domain of CENP-E. UA62784 causes reversible cell cycle arrest in mitosis before metaphase, which leads to apoptosis. The compound is not interacting with microtubules directly.

安全信息

GHS Symbol
Hazard statements
  • H302 Harmful if swallowed 吞食有害
Signal word Warning
Hazard Codes Xn
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Apoptosis and Cell Cycle - Cell Signaling and Neuroscience
  5. Cell Cycle Proteins and Antibodies - Apoptosis and Cell Cycle
  6. Cell Cycle Regulators - Cell Cycle Proteins and Antibodies
  1. Medical Research Areas
  2. Cytosketetal Signaling
  3. Kinesin

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