2-(3,4-Dimethoxybenzamido)-4,5,6,7-Tetrahydrobenzo[B]Thiophene-3-Carboxamide 2-(3,4-二甲氧基苯甲酰胺基)-4,5,6,7-四氢苯并[b]噻吩-3-甲酰胺

CAS 301305-73-7 MFCD00617269

化学结构图

301305-73-7
SMILES: COc1ccc(C(=O)Nc2sc3c(c2C(N)=O)CCCC3)cc1OC

化学属性

Mol. FormulaC18H20N2O4S
Mol. Weight360.43
Appearance Solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical Name2-(3,4-Dimethoxybenzamido)-4,5,6,7-Tetrahydrobenzo[B]Thiophene-3-Carboxamide
Synonym 2-(3,4-Dimethoxy-benzoylamino)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid amide Flt-3 inhibitor TCS359, TCS 359, TCS-359
CAS Number301305-73-7
PubChem Substance ID354334725
MDL NumberMFCD00617269
Chemical Name Translation2-(3,4-二甲氧基苯甲酰胺基)-4,5,6,7-四氢苯并[b]噻吩-3-甲酰胺
Reaxys-RN10482751
FormulaC18H20N2O4S
IUPAC Name2-(3,4-dimethoxybenzamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide
InChIKeyFSPQCTGGIANIJZ-UHFFFAOYSA-N
InChIInChI=1S/C18H20N2O4S/c1-23-12-8-7-10(9-13(12)24-2)17(22)20-18-15(16(19)21)11-5-3-4-6-14(11)25-18/h7-9H,3-6H2,1-2H3,(H2,19,21)(H,20,22)
Canonical SMILESO=C(C1=C(NC(C2=CC=C(OC)C(OC)=C2)=O)SC3=C1CCCC3)N
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分类

  • Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, DIG-DY, Kinase/Phosphatase Biology, Platelet Derived Growth Factor Receptor (PDGFR), Receptor Tyrosine Kinase Biology, Receptor Tyrosine Kinase Inhibitors
  • {SNA} Bioactive Small Molecule Alphabetical Index, DIG-DY, Kinase/Phosphatase Biology, Platelet Derived Growth Factor Receptor (PDGFR), Receptor Tyrosine Kinase Biology, Receptor Tyrosine Kinase Inhibitors, 生物活性小分子,
  • {SNA} Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, DIG-DY, Kinase/Phosphatase Biology, Platelet Derived Growth Factor Receptor (PDGFR), Receptor Tyrosine Kinase Biology, Receptor Tyrosine Kinase Inhi

产品应用

  • TCS-359 is a potent inhibitor of FLT3 with IC50 of 42 nM.

相关文献及参考

  • Patch, R.J., et al., Identification of 2-acylaminothiophene-3-carboxamides as potent inhibitors of FLT3 Bioorg. Med. Chem. Lett. 16 , 3282-3286 摘要

安全信息

GHS Symbol
WGK Germany3
Hazard Codes Xi
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
Signal word Warning
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Storage condition -20°C Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Kinase/Phosphatase Biology - Cell Signaling and Neuroscience
  5. Receptor Tyrosine Kinase Biology - Kinase/Phosphatase Biology
  6. Receptor Tyrosine Kinase Inhibitors - Receptor Tyrosine Kinase Biology
  7. Platelet Derived Growth Factor Receptor (PDGFR) - Receptor Tyrosine Kinase Inhibitors
  1. Medical Research Areas
  2. Angiogenesis
  3. FLT3

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